Cited by 197Liver physiology and pathologyLiver Disease Diagnosis and TreatmentLiver Diseases and Immunity

The DOI matches its Crossref record; 37 of the 39 references it cites were found in a registry or an index.

Cultured Human Liver Fat-Storing Cells Produce Monocyte Chemotactic Protein-1. Regulation by Proinflammatory Cytokines

Open access

Marra, F, Valente, A J, Pinzani, M, Abboud, H E·1993·Journal of Clinical Investigation

Open this paper in CoChat — free account Open PDF

Abstract

Monocytes infiltrate the portal space during chronic liver inflammation. Monocyte chemotactic protein-1 (MCP-1) is a cytokine that induces monocyte chemotaxis and activation. We investigated if human liver fat-storing cells (FSC) secrete MCP-1, and the mechanisms that regulate MCP-1 production. Unstimulated FSC secrete MCP-1 as measured by radioimmunoassay as well as a chemotactic assay and express mRNA that encodes for this cytokine. A two- to threefold increase in MCP-1 secretion was observed when FSC were treated with either interleukin-1 alpha (IL-1 alpha) or interferon-gamma (IFN-gamma). Tumor necrosis factor-alpha (TNF alpha) also increased MCP-1 secretion, although to a lesser extent (1.6-fold). Northern blot analysis showed that IL-1 alpha and IFN-gamma strongly increase the levels of mRNA that encodes for MCP-1, whereas TNF alpha appears to be a weaker stimulus. Analysis of FSC-conditioned medium by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting revealed three bands of MCP-1 that most likely represent isoforms of different apparent molecular weights. Pretreatment of FSC with H-7, a protein kinase C inhibitor, blocked cytokine-induced increase in both MCP-1 gene expression and secretion. To determine the potential role of MCP-1 in vivo, we also analyzed normal and pathologic human liver tissue. Northern blot analysis showed that MCP-1 mRNA expression is more abundant in liver tissue obtained from patients with chronic active hepatitis compared with normal liver tissue. These studies indicate that MCP-1 secreted by FSC is stimulated by proinflammatory cytokines and that MCP-1 gene expression is upregulated in chronic inflammatory liver disease. MCP-1 released by FSC may participate in the recruitment and activation of monocytes at sites of liver injury.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci116753

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,311
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C
Hidaka, H., Inagaki, M., Kawamoto, S., & Sasaki, Y. (1984) · Biochemistry · doi:10.1021/bi00316a032 · Cited by 2,688
Properties Of The Novel Proinflammatory Supergene Intercrine Cytokine Family
Oppenheim, J. J., Zachariae, C. O. C., Mukaida, N., & Matsushima, K. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.003153 · Cited by 1,878
A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas
Basset, P., Bellocq, J., Wolf, C., Stoll, I., Hutin, P., Limacher, J. M., Podhajcer, O. L., Chenard, M., Rio, M., & Chambon, P. (1990) · Nature · doi:10.1038/348699a0 · Cited by 1,125
Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.
Friedman, S. L., Roll, F. J., Boyles, J., & Bissell, D. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8681 · Cited by 859
Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein.
Navab, M., Imes, S., Hama, S. Y., Hough, G. P., Ross, L. A., Bork, R. W., Valente, A. J., Berliner, J. A., Drinkwater, D. C., & Laks, H. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115532 · Cited by 733
Self-citation
Human monocyte chemoattractant protein‐1 (MCP‐1) Full‐length cDNA cloning, expression in mitogen‐stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE
Yoshimura, T., Yuhki, N., Moore, S. K., Appella, E., Lerman, M. I., & Leonard, E. J. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)80590-3 · Cited by 589
Perisinusoidal Stellate Cells (Fat-Storing Cells, Interstitial Cells, Lipocytes), Their Related Structure in and around the Liver Sinusoids, and Vitamin A-Storing Cells in Extrahepatic Organs
Wake, K. (1980) · International review of cytology · doi:10.1016/s0074-7696(08)61977-4 · Cited by 532

Show all 39 references

Research works printed but not linked: 1

Perrillo, R. P. 1992. Chronic hepatitis. In Diseases of the Liver and the Biliary Tract. G. Gitnick, D. R. LaBrecque, and F. G. Moody, editors. Mosby- Year Book, Inc., St. Louis. 299-3 10.

Sorted by citations

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
Friedman, S. L. (2008) · Physiological Reviews · doi:10.1152/physrev.00013.2007 · Cited by 2,842
Liver fibrosis – from bench to bedside
Friedman, S. L. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00429-4 · Cited by 1,780
Roles for chemokines in liver disease
Marra, F., & Tacke, F. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.06.043 · Cited by 829
Self-citation
Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis
Popivanova, B. K., Kitamura, K., Wu, Y., Kondo, T., Kagaya, T., Kaneko, S., Oshima, M., Fujii, C., & Mukaida, N. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32453 · Cited by 845
Toll-Like Receptor 4 Mediates Inflammatory Signaling by Bacterial Lipopolysaccharide in Human Hepatic Stellate Cells
Paik, Y.-H., Schwabe, R. F., Bataller, R., Russo, M. P., Jobin, C., & Brenner, D. A. (2003) · Hepatology · doi:10.1053/jhep.2003.50182 · Cited by 651
CCR1 and CCR5 promote hepatic fibrosis in mice
Seki, E., De Minicis, S., Gwak, G.-Y., Kluwe, J., Inokuchi, S., Bursill, C. A., Llovet, J. M., Brenner, D. A., & Schwabe, R. F. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37444 · Cited by 431
Activation of hepatic stellate cells - a key issue in liver fibrosis
Reeves, H. L. (2002) · Frontiers in bioscience · doi:10.2741/reeves · Cited by 421
Redox mechanisms in hepatic chronic wound healing and fibrogenesis
Novo, E., & Parola, M. (2008) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-1-5 · Cited by 417
The MCP/eotaxin subfamily of CC chemokines
Coillie, E. V., Damme, J. V., & Opdenakker, G. (1999) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(99)00005-2 · Cited by 360
Liver fibrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy
Li, D., & Friedman, S. L. (1999) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.1999.01928.x · Cited by 337
Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells†
Aleffi, S., Petrai, I., Bertolani, C., Parola, M., Colombatto, S., Novo, E., Vizzutti, F., Anania, F. A., Milani, S., Rombouts, K., et al. (2005) · Hepatology · doi:10.1002/hep.20965 · Cited by 350
Self-citation
Liver fibrosis: from the bench to clinical targets
Pinzani, M., & Rombouts, K. (2004) · Digestive and Liver Disease · doi:10.1016/j.dld.2004.01.003 · Cited by 337
Self-citation
The hepatic stellate (Ito) cell: its role in human liver disease
Hautekèete, M., & Geerts, A. E. (1997) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01324802 · Cited by 306
Liver extracellular matrix in health and disease
Bédossa, P., & Paradis, V. (2003) · The Journal of Pathology · doi:10.1002/path.1397 · Cited by 300
HNE interacts directly with JNK isoforms in human hepatic stellate cells.
Parola, M., Robino, G., Marra, F., Pinzani, M., Bellomo, G., Leonarduzzi, G., Chiarugi, P., Camandola, S., Poli, G., Waeg, G., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1413 · Cited by 297
Self-citation
Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltration.
Marra, F., DeFranco, R., Grappone, C., Milani, S., Pastacaldi, S., Pinzani, M., Romanelli, R. G., Laffi, G., & Geñtilini, P. (1998) · Europe PMC (PubMed Central) · Cited by 289
Self-citation
Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis
Widjaja, A. A., Singh, B. K., Adami, E., Viswanathan, S., Dong, J., D’Agostino, G. A., Ng, B., Lim, W., Tan, J., Paleja, B. S., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.05.002 · Cited by 279
Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice
Berres, M., Koenen, R. R., Rueland, A., Zaldivar, M. M., Heinrichs, D., Sahin, H., Schmitz, P., Streetz, K. L., Berg, T., Gaßler, N., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41732 · Cited by 267
Functional Role of Monocytes and Macrophages for the Inflammatory Response in Acute Liver Injury
Zimmermann, H. W., Trautwein, C., & Tacke, F. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00056 · Cited by 272
Monocyte Chemotactic Protein–1 As A Chemoattractant for Human Hepatic Stellate Cells
Marra, F., Romanelli, R. G., Giannini, C., Failli, P., Pastacaldi, S., Arrighi, M. C., Pinzani, M., Laffi, G., Montalto, P., & Geñtilini, P. (1999) · Hepatology · doi:10.1002/hep.510290107 · Cited by 262
Self-citation
Human Hepatic Stellate Cells Express CCR5 and RANTES to Induce Proliferation and Migration
Schwabe, R. F., Bataller, R., & Brenner, D. A. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00215.2003 · Cited by 252
Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis
Mann, J., Oakley, F., Akiboye, F., Elsharkawy, A. M., Thorne, A. W., & Mann, D. A. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401979 · Cited by 249
Molecular regulation of hepatic fibrogenesis
Olaso, E., & Friedman, S. L. (1998) · Journal of Hepatology · doi:10.1016/s0168-8278(98)80269-9 · Cited by 241
Interleukin-6 Induces Monocyte Chemotactic Protein-1 in Peripheral Blood Mononuclear Cells and in the U937 Cell Line
Biswas, P., Delfanti, F., Bernasconi, S., Mengozzi, M., Cota, M., Polentarutti, N., Mantovani, A., Lazzarin, A., Sozzani, S., & Poli, G. (1998) · Blood · doi:10.1182/blood.v91.1.258 · Cited by 238
Cytokines in the liver
Ramadori, G. P., & Armbrust, T. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200107000-00004 · Cited by 231
Signal transduction in hepatic stellate cells
Pinzani, M., Marra, F., & Carloni, V. (1998) · Liver International · doi:10.1111/j.1600-0676.1998.tb00120.x · Cited by 229
Self-citation
Human Hepatic Stellate Cells Show Features of Antigen-Presenting Cells and Stimulate Lymphocyte Proliferation
Viñas, O., Bataller, R., Sancho-Bru, P., Ginès, P., Berenguer, C., Enrich, C., Nicolás, J. M., Ercilla, G., Gallart, T., Vives, J., et al. (2003) · Hepatology · doi:10.1002/hep.1840380418 · Cited by 223
The balancing act of the liver: tissue regeneration versus fibrosis
Cordero-Espinoza, L., & Huch, M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93562 · Cited by 233
Chemokines in liver inflammation and fibrosis
Marra, F. (2002) · Frontiers in bioscience · doi:10.2741/a887 · Cited by 214
Self-citation
Cellular mechanisms of tissue fibrosis. 5. Novel insights into liver fibrosis
Mallat, A., & Lotersztajn, S. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00230.2013 · Cited by 211
Hepatic stellate cells and the regulation of liver inflammation
Marra, F. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80327-4 · Cited by 187
Self-citation
HEPATIC FIBROSIS
Albanis, E., & Friedman, S. L. (2001) · Clinics in Liver Disease · doi:10.1016/s1089-3261(05)70168-9 · Cited by 184
Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats
Imamura, M., Ogawa, T., Sasaguri, Y., Chayama, K., & Ueno, H. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.10.005 · Cited by 177
Novel insights into the biology and physiology of the Ito cell
Pinzani, M. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(94)00072-b · Cited by 177
Self-citation
Hepatic stellate cells
Ankoma‐Sey, V., & Friedman, S. L. (1998) · Springer eBooks · doi:10.1007/978-94-011-4932-7_20 · Cited by 173
Inhibition of NFκB in activated rat hepatic stellate cells by proteasome inhibitors and an IκB super-repressor
Hellerbrand, C., Jobin, C., Iimuro, Y., Licato, L. L., Sartor, R. B., & Brenner, D. A. (1998) · Hepatology · doi:10.1002/hep.510270514 · Cited by 170
Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies
Li, J., Liao, Z., Ping, J., Xu, D., & Wang, H. (2008) · Journal of Gastroenterology · doi:10.1007/s00535-008-2180-y · Cited by 169
CD40 Activates NF-κB and c-Jun N-Terminal Kinase and Enhances Chemokine Secretion on Activated Human Hepatic Stellate Cells
Schwabe, R. F., Schnabl, B., Kweon, Y. O., & Brenner, D. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6812 · Cited by 155
Cytokine Regulation of Hepatic Stellate Cells in Liver Fibrosis
Tsukamoto, H. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04202.x · Cited by 156
Hepatic stellate cell and monocyte interaction contributes to poor prognosis in hepatocellular carcinoma
Ji, J., Eggert, T., Budhu, A., Forgues, M., Takai, A., Dang, H. T., Ye, Q., Lee, J., Kim, J. H., Greten, T. F., et al. (2015) · Hepatology · doi:10.1002/hep.27822 · Cited by 155
Expression of Intracellular Adhesion Molecule 1 by Activated Hepatic Stellate Cells
Hellerbrand, C., Wang, S. C., Tsukamoto, H., Brenner, D. A., & Rippe, R. A. (1996) · Hepatology · doi:10.1002/hep.510240333 · Cited by 152
Resistin as an Intrahepatic Cytokine
Bertolani, C., Sancho‐Bru, P., Failli, P., Bataller, R. A., Aleffi, S., DeFranco, R., Mazzinghi, B., Romagnani, P., Milani, S., Ginès, P., et al. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060081 · Cited by 153
Self-citation
Peritumoral Activated Hepatic Stellate Cells Predict Poor Clinical Outcome in Hepatocellular Carcinoma After Curative Resection
Ju, M., Qiu, S., Fan, J., Xiao, Y., Gao, Q., Zhou, J., Li, Y.-W., & Tang, Z. (2009) · American Journal of Clinical Pathology · doi:10.1309/ajcp86ppbngohnnl · Cited by 150
Expression of Interleukin-10 by in Vitro and in Vivo Activated Hepatic Stellate Cells
Wang, S. C., Ohata, M., Schrum, L. W., Rippe, R. A., & Tsukamoto, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.302 · Cited by 150
Nuclear factor κB in proliferation, activation, and apoptosis in rat hepatic stellate cells
Lang, A., Schoonhoven, R., Tuvia, S., Brenner, D. A., & Rippe, R. A. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80159-2 · Cited by 143
Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells
Brun, P., Castagliuolo, I., Pinzani, M., Palù, G., & Martines, D. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00537.2004 · Cited by 147
Self-citation
gp120 modulates the biology of human hepatic stellate cells: a link between HIV infection and liver fibrogenesis
Bruno, R., Galastri, S., Sacchi, P., Cima, S., Caligiuri, A., DeFranco, R., Milani, S., Gessani, S., Fantuzzi, L., Liotta, F., et al. (2009) · Gut · doi:10.1136/gut.2008.163287 · Cited by 142
Self-citation
Iron, oxidative stress and liver fibrogenesis
Pietrangelo, A. (1998) · Journal of Hepatology · doi:10.1016/s0168-8278(98)80368-1 · Cited by 140
Alpha-melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation.
Chiao, H., Foster, S. J., Thomas, R., Lipton, J. M., & Star, R. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118639 · Cited by 140
Hepatic stellate (ITO) cells: expanding roles for a liver-specific pericyte
Pinzani, M. (1995) · Journal of Hepatology · doi:10.1016/0168-8278(95)80227-4 · Cited by 139
Self-citation
Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options
Gressner, O. A., Weiskirchen, R., & Gressner, A. M. (2007) · Comparative Hepatology · doi:10.1186/1476-5926-6-7 · Cited by 136
Molecular mechanisms of hepatic fibrosis and principles of therapy
Friedman, S. L. (1997) · Journal of Gastroenterology · doi:10.1007/bf02934504 · Cited by 129
Human hepatic stellate cell isolation and characterization
Shang, L., Hosseini, M., Liu, X., Kisseleva, T., & Brenner, D. A. (2017) · Journal of Gastroenterology · doi:10.1007/s00535-017-1404-4 · Cited by 131
NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension
Fiorucci, S., Antonelli, E., Morelli, O., Mencarelli, A., Casini, A., Mello, T., Palazzetti, B., Tallet, D., Soldato, P. D., & Morelli, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151136298 · Cited by 128
Expression and Regulation of Cell Adhesion Molecules by Hepatic Stellate Cells (HSC) of Rat Liver
Knittel, T. E., Dinter, C., Kobold, D., Neubauer, K., Mehde, M., Eichhorst, S. T., & Ramadori, G. P. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65262-5 · Cited by 124
4-Hydroxynonenal as a selective pro-fibrogenic stimulus for activated human hepatic stellate cells
Zamara, E., Novo, E., Marra, F., Gentilini, A., Romanelli, R. G., Caligiuri, A., Robino, G., Tamagno, E., Aragno, M., Danni, O., et al. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00480-x · Cited by 123
Self-citation
The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis
Tsatsanis, C., Dermitzaki, E., Avgoustinaki, P. D., Malliaraki, N. E., Mytaras, V., & Margioris, A. N. (2015) · HORMONES · doi:10.14310/horm.2002.1649 · Cited by 122
Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: Potential role in liver injury
Marra, F., Grandaliano, G., Valente, A. J., & Abboud, H. E. (1995) · Hepatology · doi:10.1002/hep.1840220314 · Cited by 118
Self-citation
Functional Immune Anatomy of the Liver—As an Allograft
Demetris, A. J., Bellamy, C. O. C., Gandhi, C. R., Prost, S., Nakanuma, Y., & Stolz, D. B. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13749 · Cited by 117
Hepatic Fibrosis, Stellate Cells, and Portal Hypertension
Rockey, D. C. (2006) · Clinics in Liver Disease · doi:10.1016/j.cld.2006.08.017 · Cited by 112
Functional role of chemokines in liver disease models
Sahin, H., Trautwein, C., & Wasmuth, H. E. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.168 · Cited by 107
Hepatic stellate cells: balancing homeostasis, hepatoprotection and fibrogenesis in health and disease
Schwabe, R. F., & Brenner, D. A. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01068-6 · Cited by 112
Molecular Mechanisms of Liver Fibrosis in HIV/HCV Coinfection
Mastroianni, C. M., Lichtner, M., Mascia, C., Zuccalà, P., & Vullo, V. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15069184 · Cited by 108
Induction of Monocyte Chemoattractant Protein-1 Synthesis in Human Monocytes During Transendothelial Migration In Vitro
Takahashi, M., Masuyama, J., Ikeda, U., Kasahara, T., Kitagawa, S., Takahashi, Y., Shimada, K., & Kano, S. (1995) · Circulation Research · doi:10.1161/01.res.76.5.750 · Cited by 105
Stellate Cells in Tissue Repair, Inflammation, and Cancer
Sherman, M. H. (2018) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100617-062855 · Cited by 104
Prevention of severe toxic liver injury and oxidative stress in MCP-1-deficient mice
Zamara, E., Galastri, S., Aleffi, S., Petrai, I., Aragno, M., Mastrocola, R., Novo, E., Bertolani, C., Milani, S., Vizzutti, F., et al. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.09.007 · Cited by 102
Self-citation
Immune Interactions in Hepatic Fibrosis
Holt, A. P., Salmon, M., Buckley, C. D., & Adams, D. (2008) · Clinics in Liver Disease · doi:10.1016/j.cld.2008.07.002 · Cited by 104
Cytokines induce NF-κB in activated but not in quiescent rat hepatic stellate cells
Hellerbrand, C., Jobin, C., Licato, L. L., Sartor, R. B., & Brenner, D. A. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.2.g269 · Cited by 101
stellate Cell Activation in Alcoholic Fibrosi—An Overview
Friedman, S. L. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04201.x · Cited by 101
Chemokines: a superfamily of chemotactic cytokines
Sozzani, S., Locati, M., Allavena, P., Damme, J. V., & Mantovani, A. (1996) · International Journal of Clinical & Laboratory Research · doi:10.1007/bf02592349 · Cited by 99
A novel biologic activity of thrombin: stimulation of monocyte chemotactic protein production.
Grandaliano, G., Valente, A. J., & Abboud, H. E. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.5.1737 · Cited by 99
Self-citation
Expression of the thrombin receptor in human liver: Up-regulation during acute and chronic injury
Marra, F., DeFranco, R., Grappone, C., Milani, S., Pinzani, M., Pellegrini, G., Laffi, G., & Geñtilini, P. (1998) · Hepatology · doi:10.1002/hep.510270221 · Cited by 98
Self-citation
Role of the stromal-derived factor-1 (SDF-1)–CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma
Gentilini, A., Rombouts, K., Galastri, S., Caligiuri, A., Mingarelli, E., Mello, T., Marra, F., Mantero, S., Roncalli, M. G., Invernizzi, P., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.06.012 · Cited by 96
Self-citation
Expression of Monocyte Chemotactic Protein-1 Precedes Monocyte Recruitment in a Rat Model of Acute Liver Injury, and is Modulated by Vitamin E
Marra, F., DeFranco, R., Grappone, C., Parola, M., Milani, S., Leonarduzzi, G., Pastacaldi, S., Wenzel, U. O., Pinzani, M., Dianzani, M. U., et al. (1999) · Journal of Investigative Medicine · doi:10.1177/108155899904700110 · Cited by 95
Self-citation
Mononuclear cells in liver fibrosis
Marra, F., Aleffi, S., Galastri, S., & Provenzano, A. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0169-0 · Cited by 89
Self-citation
Regulation of Fibrosis by the Immune System
Lupher, M., & Gallatin, W. M. (2006) · Advances in immunology · doi:10.1016/s0065-2776(05)89006-6 · Cited by 93
Involvement of phosphatidylinositol 3‐kinase in the activation of extracellular signal‐regulated kinase by PDGF in hepatic stellate cells
Marra, F., Pinzani, M., DeFranco, R., Laffi, G., & Geñtilini, P. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01261-0 · Cited by 86
Self-citation
Starring stellate cells in liver immunology
Winau, F., Breunig, C., Darmoise, A., & Kaufmann, S. H. E. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.10.006 · Cited by 87
Rat hepatic stellate cells produce cytokine-induced neutrophil chemoattractant in culture and in vivo
Maher, J. J., Lozier, J. S., & Scott, M. K. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.4.g847 · Cited by 82
Circulating Concentrations of Monocyte Chemoattractant Protein-1, Plasminogen Activator Inhibitor-1, and Soluble Leukocyte Adhesion Molecule-1 in Overweight/Obese Men and Women Consuming Fructose- or Glucose-Sweetened Beverages for 10 Weeks
Cox, C. L., Stanhope, K. L., Schwarz, J. M., Graham, J. L., Hatcher, B., Griffen, S. C., Bremer, A. A., Berglund, L., McGahan, J. P., Keim, N. L., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1050 · Cited by 84
Antifibrotic effects of tetrandrine on hepatic stellate cells and rats with liver fibrosis
Hsu, Y., Chiu, Y., Cheng, C., Wu, C., Lin, Y., & Huang, Y. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04361.x · Cited by 82
Changing the pathogenetic roadmap of liver fibrosis? Where did it start; where will it go?
Gressner, O. A., Rizk, M. S., Kovalenko, E. P., Weiskirchen, R., & Gressner, A. M. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05345.x · Cited by 81
Hepatic Stellate Cell-Immune Interactions in NASH
Carter, J. K., & Friedman, S. L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.867940 · Cited by 79
Long-term consequences of obesity on female fertility and the health of the offspring
Chandrasekaran, S., & Neal-Perry, G. S. (2017) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000364 · Cited by 80
The Chemokine CCL3 Promotes Experimental Liver Fibrosis in Mice
Heinrichs, D., Berres, M., Nellen, A., Fischer, P., Scholten, D., Trautwein, C., Wasmuth, H. E., & Sahin, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066106 · Cited by 79
Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols
Ferré, N., Martínez‐Clemente, M., López‐Parra, M., González‐Périz, A., Horrillo, R., Planagumà, A., Camps, J., Joven, J., Tres, A., Guardiola, F., et al. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00547.2007 · Cited by 78
Effect of tumour necrosis factor-α on proliferation, activation and protein synthesis of rat hepatic stellate cells
Knittel, T. E., Müller, L. P., Saile, B., & Ramadori, G. P. (1997) · Journal of Hepatology · doi:10.1016/s0168-8278(97)80151-1 · Cited by 77
Potential Interaction between CCR1 and Its Ligand, CCL3, Induced by Endogenously Produced Interleukin-1 in Human Hepatomas
Lu, P., Nakamoto, Y., Nemoto‐Sasaki, Y., Fujii, C., Wang, H., Hashii, M., Ohmoto, Y., Kaneko, S., KOBAYASHI, K. P., & Mukaida, N. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63921-1 · Cited by 77
Agonist-specific regulation of monocyte chemoattractant protein-1 expression by cyclooxygenase metabolites in hepatic stellate cells
Efsen, E. (2001) · Hepatology · doi:10.1053/jhep.2001.22761 · Cited by 75
Interferon-gamma-mediated activation of STAT1alpha regulates growth factor-induced mitogenesis.
Marra, F., Choudhury, G. G., & Abboud, H. E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118905 · Cited by 73
Self-citation
Monocyte Chemotactic Protein-1 Expression Is Associated With the Development of Vein Graft Intimal Hyperplasia
Stark, V. K., Hoch, J. R., WARNER, T. F. C. S., & Hullett, D. A. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.8.1614 · Cited by 72
Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells
Siegmund, S., Schlosser, M., Schildberg, F. A., Seki, E., Minicis, S. D., Uchinami, H., Kuntzen, C., Knolle, P. A., Strassburg, C. P., & Schwabe, R. F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150893 · Cited by 66
Targeting activation-induced cytidine deaminase prevents colon cancer development despite persistent colonic inflammation
Takai, A., Marusawa, H., Minaki, Y., Watanabe, T., Nakase, H., Kinoshita, K., Tsujimoto, G., & Chiba, T. (2011) · Oncogene · doi:10.1038/onc.2011.352 · Cited by 66
Limited role for CXC chemokines in the pathogenesis of α-naphthylisothiocyanate-induced liver injury
Xu, J., Lee, G. T., Wang, H., Vierling, J. M., & Maher, J. J. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00300.2003 · Cited by 64
THE CELL AND MOLECULAR BIOLOGY OF HEPATIC FIBROGENESIS
Rockey, D. C. (2000) · Clinics in Liver Disease · doi:10.1016/s1089-3261(05)70113-6 · Cited by 62
Interaction between 4-Hydroxy-2,3-alkenals and the Platelet-derived Growth Factor-β Receptor
Robino, G., Parola, M., Marra, F., Caligiuri, A., Franco, R. D., Zamara, E., Bellomo, G., Geñtilini, P., Pinzani, M., & Dianzani, M. U. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007694200 · Cited by 63
Self-citation
Regulation of platelet-derived growth factor secretion and gene expression in human liver fat-storing cells
Marra, F., Choudhury, G. G., Pinzani, M., & Abboud, H. E. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90236-4 · Cited by 63
Self-citation
Molecular aspects of medicine: from experimental to clinical hepatology
Häussinger, D. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.02.001 · Cited by 62
Targeting Hepatic Stellate Cells for the Treatment of Liver Fibrosis by Natural Products: Is It the Dawning of a New Era?
Chan, Y.-T., Wang, N., Tan, H. Y., Li, S., & Feng, Y. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00548 · Cited by 63
Secretion of monocyte chemotactic activity by cultured rat aortic smooth muscle cells in response to PDGF is due predominantly to the induction of JE/MCP-1.
Poon, M., Hsu, W. C., Bogdanov, V. Y., & Taubman, M. B. (1996) · Europe PMC (PubMed Central) · Cited by 61

Authors: Marra, F., Valente, A. J., Pinzani, M., & Abboud, H. E.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
University of Florence (IT)
ORCID: Marra, F
Pinzani, M
Abboud, H E
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1993-10-01
Volume: 92
Issue: 4
Pages: 1674-1680
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci116753
PMC: PMC288326
OpenAlex: W2062874643
Cited by: 197
References: 39
Citations by year: 2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 9 · 2014: 4 · 2013: 4 · 2012: 7
FWCI: 6.71
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Florence Research (University of Florence) (submittedVersion)
Funders: National Institutes of Health (5r01dk043988-09, 33665, 5p01hl026890-10)
National Heart, Lung, and Blood Institute (HL-26890)
National Institute of Diabetes and Digestive and Kidney Diseases (DK43988, DK-33665)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
Keywords: MCP-1, hepatocytes, inflammatory cytokines, interleukin-1 alpha, interferon-gamma, TNF-α, protein kinase C, chronic active hepatitis, monocyte recruitment, chronic liver inflammation, MCP-1 gene expression
MeSH terms: Cells, Cultured, Chemotactic Factors, Electrophoresis, Polyacrylamide Gel, Humans, Inflammation, Interferon-gamma, Interleukin-1, Isoquinolines, Liver, Molecular Weight, Piperazines, Platelet-Derived Growth Factor, Protein Kinase C, Radioimmunoassay, Recombinant Proteins, RNA, Messenger, Tumor Necrosis Factor-alpha, Blotting, Northern, Gene Expression, Cytokines, Adipocytes, Chemokine CCL2, 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine, Culture Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cultured Human Liver Fat-Storing Cells Produce Monocyte Chemotactic Protein-1. Regulation by Proinflammatory Cytokines

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks