Cited by 197Liver physiology and pathologyLiver Disease Diagnosis and TreatmentLiver Diseases and Immunity

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Cultured Human Liver Fat-Storing Cells Produce Monocyte Chemotactic Protein-1. Regulation by Proinflammatory Cytokines

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Marra, F, Valente, A J, Pinzani, M, Abboud, H E·1993·Journal of Clinical Investigation

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Abstract

Monocytes infiltrate the portal space during chronic liver inflammation. Monocyte chemotactic protein-1 (MCP-1) is a cytokine that induces monocyte chemotaxis and activation. We investigated if human liver fat-storing cells (FSC) secrete MCP-1, and the mechanisms that regulate MCP-1 production. Unstimulated FSC secrete MCP-1 as measured by radioimmunoassay as well as a chemotactic assay and express mRNA that encodes for this cytokine. A two- to threefold increase in MCP-1 secretion was observed when FSC were treated with either interleukin-1 alpha (IL-1 alpha) or interferon-gamma (IFN-gamma). Tumor necrosis factor-alpha (TNF alpha) also increased MCP-1 secretion, although to a lesser extent (1.6-fold). Northern blot analysis showed that IL-1 alpha and IFN-gamma strongly increase the levels of mRNA that encodes for MCP-1, whereas TNF alpha appears to be a weaker stimulus. Analysis of FSC-conditioned medium by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting revealed three bands of MCP-1 that most likely represent isoforms of different apparent molecular weights. Pretreatment of FSC with H-7, a protein kinase C inhibitor, blocked cytokine-induced increase in both MCP-1 gene expression and secretion. To determine the potential role of MCP-1 in vivo, we also analyzed normal and pathologic human liver tissue. Northern blot analysis showed that MCP-1 mRNA expression is more abundant in liver tissue obtained from patients with chronic active hepatitis compared with normal liver tissue. These studies indicate that MCP-1 secreted by FSC is stimulated by proinflammatory cytokines and that MCP-1 gene expression is upregulated in chronic inflammatory liver disease. MCP-1 released by FSC may participate in the recruitment and activation of monocytes at sites of liver injury.

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
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Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,311
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C
Hidaka, H., Inagaki, M., Kawamoto, S., & Sasaki, Y. (1984) · Biochemistry · doi:10.1021/bi00316a032 · Cited by 2,688
Properties Of The Novel Proinflammatory Supergene Intercrine Cytokine Family
Oppenheim, J. J., Zachariae, C. O. C., Mukaida, N., & Matsushima, K. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.003153 · Cited by 1,878
A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas
Basset, P., Bellocq, J., Wolf, C., Stoll, I., Hutin, P., Limacher, J. M., Podhajcer, O. L., Chenard, M., Rio, M., & Chambon, P. (1990) · Nature · doi:10.1038/348699a0 · Cited by 1,125
Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.
Friedman, S. L., Roll, F. J., Boyles, J., & Bissell, D. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8681 · Cited by 859
Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein.
Navab, M., Imes, S., Hama, S. Y., Hough, G. P., Ross, L. A., Bork, R. W., Valente, A. J., Berliner, J. A., Drinkwater, D. C., & Laks, H. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115532 · Cited by 733
Self-citation
Human monocyte chemoattractant protein‐1 (MCP‐1) Full‐length cDNA cloning, expression in mitogen‐stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE
Yoshimura, T., Yuhki, N., Moore, S. K., Appella, E., Lerman, M. I., & Leonard, E. J. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)80590-3 · Cited by 589
Perisinusoidal Stellate Cells (Fat-Storing Cells, Interstitial Cells, Lipocytes), Their Related Structure in and around the Liver Sinusoids, and Vitamin A-Storing Cells in Extrahepatic Organs
Wake, K. (1980) · International review of cytology · doi:10.1016/s0074-7696(08)61977-4 · Cited by 532

Show all 39 references

Research works printed but not linked: 1

Perrillo, R. P. 1992. Chronic hepatitis. In Diseases of the Liver and the Biliary Tract. G. Gitnick, D. R. LaBrecque, and F. G. Moody, editors. Mosby- Year Book, Inc., St. Louis. 299-3 10.

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Self-citation
Glomerular size and global glomerulosclerosis in normal Caucasian donor kidneys: effects of aging and gender.
Li, M., Nicholls, K., & Becker, G. J. (2002) · PubMed · Cited by 17
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Hsieh, C., Huang, C., Huang, L., Tsai, Y., Chou, M.-H., & Chuang, J. (2003) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2003.09.012 · Cited by 16
Chemokines as targets for pharmacological intervention
Sozzani, S., Allavena, P., Proost, P., Damme, J. V., & Mantovani, A. (1996) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8998-8_2 · Cited by 16
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Rippe, R. A. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04205.x · Cited by 12
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Song, X.-Y., Zeng, L., Pilo, C. M., Zagorski, J., & Wahl, S. M. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.4020 · Cited by 12
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Braz, M. M., Ramalho, F. S., Cardoso, R. L., Zucoloto, S., Costa, R. S., & Ramalho, L. N. Z. (2009) · Acta Tropica · doi:10.1016/j.actatropica.2009.09.008 · Cited by 11
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Self-citation
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Arthur, M. J. P. (1996) · Human & Experimental Toxicology · doi:10.1177/096032719601500207 · Cited by 9
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Modulating hepatic stellate cell senescence: A promising therapeutic strategy for liver fibrosis
Sharmila, M., Harini, K. S., & Ezhilarasan, D. (2026) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2026.04.006

Authors: Marra, F., Valente, A. J., Pinzani, M., & Abboud, H. E.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
University of Florence (IT)
ORCID: Marra, F
Pinzani, M
Abboud, H E
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1993-10-01
Volume: 92
Issue: 4
Pages: 1674-1680
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci116753
PMC: PMC288326
OpenAlex: W2062874643
Cited by: 197
References: 39
Citations by year: 2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 9 · 2014: 4 · 2013: 4 · 2012: 7
FWCI: 6.71
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Florence Research (University of Florence) (submittedVersion)
Funders: National Institutes of Health (5r01dk043988-09, 33665, 5p01hl026890-10)
National Heart, Lung, and Blood Institute (HL-26890)
National Institute of Diabetes and Digestive and Kidney Diseases (DK43988, DK-33665)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
Keywords: MCP-1, hepatocytes, inflammatory cytokines, interleukin-1 alpha, interferon-gamma, TNF-α, protein kinase C, chronic active hepatitis, monocyte recruitment, chronic liver inflammation, MCP-1 gene expression
MeSH terms: Cells, Cultured, Chemotactic Factors, Electrophoresis, Polyacrylamide Gel, Humans, Inflammation, Interferon-gamma, Interleukin-1, Isoquinolines, Liver, Molecular Weight, Piperazines, Platelet-Derived Growth Factor, Protein Kinase C, Radioimmunoassay, Recombinant Proteins, RNA, Messenger, Tumor Necrosis Factor-alpha, Blotting, Northern, Gene Expression, Cytokines, Adipocytes, Chemokine CCL2, 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine, Culture Techniques

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Cultured Human Liver Fat-Storing Cells Produce Monocyte Chemotactic Protein-1. Regulation by Proinflammatory Cytokines

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