The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Expression and distribution of aquaporin of collecting duct are regulated by vasopressin V2 receptor in rat kidney.
Open accessAbstract
To examine whether expression and distribution of aquaporin of collecting duct (AQP-CD) are regulated by vasopressin V2 receptor (V2R), we performed immunohistochemical studies with specific antibody against AQP-CD. Normal Wistar rats were divided into four groups and treated for 3 d; control, dehydration, vasopressin V1 receptor (V1R) antagonist (OPC-21268 120 mg/kg), V2R antagonist (OPC-31260 30 mg/kg). At time of death, urine osmolality (Uosm) in the dehydration group (1884 +/- 245 mOsm/kg) was significantly higher than that in the control (938 +/- 91). In the V2R antagonist group, Uosm was significantly decreased to 249 +/- 29, whereas V1R antagonist showed no effect on Uosm. In the control and V1R antagonist groups, immunofluorescence studies showed the AQP-CD staining of both apical membrane and subapical cytoplasm of CD cells of the cortex and the inner medulla. Dehydration increased the immunostaining of both apical membrane and subapical cytoplasm of CD cells of the inner medulla, and the degree of increase was dominant in apical membrane. In the V2R antagonist group, only faint staining of apical membrane and weak labeling of cytoplasm of CD cells of the inner medulla were observed. These changes in the localization and protein amount of AQP-CD by dehydration and V2R antagonist were quantitatively confirmed by immunogold studies and immunoblot analysis of the inner medulla. The present results indicate that the distribution and amount of AQP-CD in the CD cells are regulated by vasopressin V2 receptor.
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Lolait, S. J., O'Carroll, A.-M., McBride, O. W., Konig, M., Morel, A., & Brownstein, M. J. (1992) · Nature · doi:10.1038/357336a0 · Cited by 524 · cited 1×
“Vasopressin VI receptor is mainly present in the vascular beds (18) and regulates the contraction of vascular smooth cells, whereas vasopressin V2 receptor localizes exclusively in the collecting duct systems (19) and plays an important role in the regulation of water reabsorption.”
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Cited by
Aquaporins in the Kidney: From Molecules to Medicine
Nielsen, S., Frøkiær, J., Marples, D., Kwon, T.-H., Agre, P., & Knepper, M. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00024.2001 · Cited by 1,251
The Basic and Clinical Pharmacology of Nonpeptide Vasopressin Receptor Antagonists
Thibonnier, M., Coles, P., Thibonnier, A., & Shoham, M. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.175 · Cited by 146
Metadata
- Authors
- Hayashi, M., Sasaki, S., Tsuganezawa, H., Monkawa, T., Kitajima, W., Konishi, K., Fushimi, K., Marumo, F., & Saruta, T.
- Venue
- Journal of Clinical Investigation
- Published
- 1994-11-01
- Volume
- 94
- Issue
- 5
- Pages
- 1778-1783
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2032455458
- Cited by
- 174
- References
- 1
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hayashi, M., Sasaki, S., Tsuganezawa, H., Monkawa, T., Kitajima, W., Konishi, K., Fushimi, K., Marumo, F., & Saruta, T. (1994). Expression and distribution of aquaporin of collecting duct are regulated by vasopressin V2 receptor in rat kidney. Journal of Clinical Investigation. https://doi.org/10.1172/jci117525
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