The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Monocyte chemotactic protein-1 (MCP-1), -2, and -3 are chemotactic for human T lymphocytes.
Open accessAbstract
Monocyte chemotactic protein (MCP)-1, -2, and -3 all have been shown to induce monocyte/macrophage migration in vitro and MCP-1, also known as MCAF, chemoattracts basophils and mast cells. We report here that natural MCP-1 as well as synthetic preparations of MCP-2 and MCP-3 stimulate significant in vitro chemotaxis of human peripheral blood T lymphocytes. This MCP-induced migration was dose-dependent and directional, but not chemokinetic. Phenotypic analysis of the T cell population responsive to MCP-1, MCP-2, and MCP-3 demonstrates that both CD4+ and CD8+ T cells migrated in response to these chemokines. Similar results were observed using human CD4+ and CD8+ T cell clones. Neutralizing antisera to MCAF or MCP-2 abrogated T cell migration in response to MCP-1 and MCP-2, respectively, but not to RANTES. Subcutaneous administration of purified MCP-1 into the hind flanks of SCID mice engrafted with human peripheral blood lymphocytes (PBL) induced significant human CD3+ T cell infiltration into the site of injection at 4 h. These results demonstrate that MCP-1, MCP-2, and MCP-3 are inflammatory mediators that specifically stimulate the directional migration of T cells as well as monocytes and may play an important role in immune cell recruitment into sites of antigenic challenge.
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Cites
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Cited by
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Schaier, M., Vorwalder, S., Sommerer, C., Dikow, R., Hug, F., Gross, M.-L., Waldherr, R., & Zeier, M. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90530.2008 · Cited by 28
Metadata
- Authors
- Taub, D. D., Proost, P., Murphy, W. J., Anver, M., Longo, D. L., van Damme, J., & Oppenheim, J. J.
- Venue
- Journal of Clinical Investigation
- Published
- 1995-03-01
- Volume
- 95
- Issue
- 3
- Pages
- 1370-1376
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2130005272
- Cited by
- 346
- References
- 22
- FWCI
- 14.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Taub, D. D., Proost, P., Murphy, W. J., Anver, M., Longo, D. L., van Damme, J., & Oppenheim, J. J. (1995). Monocyte chemotactic protein-1 (MCP-1), -2, and -3 are chemotactic for human T lymphocytes. Journal of Clinical Investigation. https://doi.org/10.1172/jci117788
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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