Cited by 647Cardiovascular and exercise physiologyHemoglobin structure and functionHigh Altitude and Hypoxia

The DOI matches its Crossref record; 46 of the 47 references it cites were found in a registry or an index.

Myoglobin O2 desaturation during exercise. Evidence of limited O2 transport.

Open access

Richardson, R S, Noyszewski, E A, Kendrick, K F, Leigh, J S, Wagner, P D·1995·Journal of Clinical Investigation

Open this paper in CoChat — free account Open PDF

Abstract

The assumption that cellular oxygen pressure (PO2) is close to zero in maximally exercising muscle is essential for the hypothesis that O2 transport between blood and mitochondria has a finite conductance that determines maximum O2 consumption. The unique combination of isolated human quadriceps exercise, direct measures of arterial, femoral venous PO2, and 1H nuclear magnetic resonance spectroscopy to detect myoglobin desaturation enabled this assumption to be tested in six trained men while breathing room air (normoxic, N) and 12% O2 (hypoxic, H). Within 20 s of exercise onset partial myoglobin desaturation was evident even at 50% of maximum O2 consumption, was significantly greater in H than N, and was then constant at an average of 51 +/- 3% (N) and 60 +/- 3% (H) throughout the incremental exercise protocol to maximum work rate. Assuming a myoglobin PO2 where 50% of myoglobin binding sites are bound with O2 of 3.2 mmHg, myoglobin-associated PO2 averaged 3.1 +/- .3 (N) and 2.1 +/- .2 mmHg (H). At maximal exercise, measurements of arterial PO2 (115 +/- 4 [N] and 46 +/- 1 mmHg [H]) and femoral venous PO2 (22 +/- 1.6 [N] and 17 +/- 1.3 mmHg [H]) resulted in calculated mean capillary PO2 values of 38 +/- 2 (N) and 30 +/- 2 mmHg(H). Thus, for the first time, large differences in PO2 between blood and intracellular tissue have been demonstrated in intact normal human muscle and are found over a wide range of exercise intensities. These data are consistent with an O2 diffusion limitation across the 1-5-microns path-length from red cell to the sarcolemma that plays a role in determining maximal muscle O2 uptake in normal humans.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci118237

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Maximal perfusion of skeletal muscle in man.
Andersen, P., & Saltin, B. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015794 · Cited by 1,250
Glycogen, Glycolytic Intermediates and High-Energy Phosphates Determined in Biopsy Samples of Musculus Quadriceps Femoris of Man at Rest. Methods and Variance of Values
Harris, R. C., Hultman, E., & Nordesjö, L. ‐. (1974) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517409082477 · Cited by 948
Esophageal, rectal, and muscle temperature during exercise
Saltin, B., & Hermansen, L. (1966) · Journal of Applied Physiology · doi:10.1152/jappl.1966.21.6.1757 · Cited by 560
NMR of paramagnetic molecules in biological systems
Maret, W. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90601-4 · Cited by 559
Transport Of Oxygen In Muscle
Wittenberg, B. A., & Wittenberg, J. B. (1989) · Annual Review of Physiology · doi:10.1146/annurev.ph.51.030189.004233 · Cited by 469
Respiratory Physiology: The Essentials
Jones, S. L. (1975) · Physical Therapy · doi:10.1093/ptj/55.5.563a · Cited by 457
Anthropometric determination of leg fat and muscle plus bone volumes in young male and female adults.
Jones, P. R., & Pearson, J. (1969) · PubMed · Cited by 430
Studies on the oxygen and carbon monoxide equilibria of human myoglobin
Rossi‐Fanelli, A., & Antonini, E. (1958) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(58)90094-8 · Cited by 422
Dynamic knee extension as model for study of isolated exercising muscle in humans
Andersen, P., Adams, R. P., Sjøgaard, G., Thorboe, A., & Saltin, B. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.59.5.1647 · Cited by 385
Anaerobic energy production and O2 deficit‐debt relationship during exhaustive exercise in humans.
Bangsbo, J., Gollnick, P. D., Graham, T. E., Juel, C., Kiens, B., Mizuno, M., & Saltin, B. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018000 · Cited by 357

Flagged first, then by citations

Show all 47 references

1 of the 47 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Hultman, E., J. Bergstrom, and N. Anderson. 1967. Breakdown and resyn- thesis of phosphoylctreatine and adenosine triphosphate in connection with muscu- lar work in man. Scand. J. Clin. Lab. Invest. 19(1):55-66.

Sorted by citations

Items 101–200 of 642

Highly Athletic Terrestrial Mammals: Horses and Dogs
Poole, D. C., & Erickson, H. H. (2011) · Comprehensive physiology · doi:10.1002/cphy.c091001 · Cited by 118
Relative Proximity of Critical Power and Metabolic/Ventilatory Thresholds: Systematic Review and Meta-Analysis
Galán‐Rioja, M. Á., González‐Mohíno, F., Poole, D. C., & González‐Ravé, J. M. (2020) · Sports Medicine · doi:10.1007/s40279-020-01314-8 · Cited by 117
Limits to sustainable muscle performance: interaction between glycolysis and oxidative phosphorylation
Conley, K. E., Kemper, W. F., & Crowther, G. J. (2001) · Journal of Experimental Biology · doi:10.1242/jeb.204.18.3189 · Cited by 117
A theoretical model for oxygen transport in skeletal muscle under conditions of high oxygen demand
McGuire, B. J., & Secomb, T. W. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.5.2255 · Cited by 117
Muscle metabolism from near infrared spectroscopy during rhythmic handgrip in humans
Boushel, R., Pott, F., Madsen, P., Rådegran, G., Nowak, M., Quistorff, B., & Secher, N. (1998) · European Journal of Applied Physiology and Occupational Physiology · doi:10.1007/s004210050471 · Cited by 122
Determinants of maximal O2uptake in rats selectively bred for endurance running capacity
Henderson, K. K., Wagner, H. E., Favret, F., Britton, S. L., Koch, L. G., Wagner, P. D., & González, N. C. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00809.2001 · Cited by 111
Self-citation
Haemodynamic responses to exercise, ATP infusion and thigh compression in humans: insight into the role of muscle mechanisms on cardiovascular function
González‐Alonso, J., Mortensen, S. P., Jeppesen, T. D., Ali, L., Barker, H., Damsgaard, R., Secher, N. H., Dawson, E. A., & Dufour, S. P. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.152058 · Cited by 114
HIF-1α in endurance training: suppression of oxidative metabolism
Mason, S. D., Rundqvist, H., Papandreou, I., Duh, R., McNulty, W., Howlett, R. A., Olfert, I. M., Sundberg, C. J., Denko, N. C., Poellinger, L., et al. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00335.2007 · Cited by 114
Lower capillarization, VEGF protein, and VEGF mRNA response to acute exercise in the vastus lateralis muscle of aged vs. young women
Croley, A. N., Zwetsloot, K. A., Westerkamp, L. M., Ryan, N. A., Pendergast, A. M., Hickner, R. C., Pofahl, W. E., & Gavin, T. P. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00498.2005 · Cited by 113
Reactive oxygen species formation in the transition to hypoxia in skeletal muscle
Zuo, L., & Clanton, T. L. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00449.2004 · Cited by 113
Myoglobin facilitates oxygen diffusion
Merx, M. W., Flögel, U., Stumpe, T., Gödecke, A., Decking, U. K. M., & Schrader, J. (2001) · The FASEB Journal · doi:10.1096/fj.00-0497fje · Cited by 113
Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease: A Statement of the American Thoracic Society and European Respiratory Society
Berton, E., Antonucci, R., & Palange, P. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.supplement_1.15945 · Cited by 111
Molecular Mechanisms of Muscle Plasticity with Exercise
Hoppeler, H. H., Baum, O., Lurman, G. J., & Mueller, M. (2011) · Comprehensive physiology · doi:10.1002/cphy.c100042 · Cited by 131
Electron paramagnetic spectroscopic evidence of exercise-induced free radical accumulation in human skeletal muscle
Bailey, D. M., Lawrenson, L., McEneny, J., Young, I. S., James, P. E., Jackson, S. K., Henry, R. R., Mathieu-Costello, O. A., McCord, J. M., & Richardson, R. S. (2007) · Free Radical Research · doi:10.1080/10715760601028867 · Cited by 116
Self-citation
Dynamics of muscle microcirculatory and blood–myocyte O2flux during contractions
Poole, D. C., Copp, S. W., Hirai, D. M., & Musch, T. I. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02246.x · Cited by 106
Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice
Grange, R. W., Meeson, A. P., Chin, E., Lau, K. S., Stull, J. T., Shelton, J. M., Williams, R. S., & Garry, D. J. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.5.c1487 · Cited by 106
Training in hypoxia and its effects on skeletal muscle tissue
Hoppeler, H. H., Klossner, S., & Vogt, M. (2008) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2008.00831.x · Cited by 106
Oxygen uptake kinetics during two bouts of heavy cycling separated by fatiguing sprint exercise in humans
Tordi, N., Perrey, S., Harvey, A., & Hughson, R. L. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00532.2002 · Cited by 106
Structural basis of muscle O2 diffusing capacity: evidence from muscle function in situ
Hepple, R. T., Hogan, M. C., Stary, C. M., Bebout, D. E., Mathieu-Costello, O. A., & Wagner, P. D. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.2.560 · Cited by 106
Self-citation
Regular endurance training reduces the exercise induced HIF-1α and HIF-2α mRNA expression in human skeletal muscle in normoxic conditions
Lundby, C., Gassmann, M., & Pilegaard, H. (2005) · European Journal of Applied Physiology · doi:10.1007/s00421-005-0085-5 · Cited by 104
Running Forward
Rowe, G. C., Safdar, A., & Arany, Z. P. (2014) · Circulation · doi:10.1161/circulationaha.113.001590 · Cited by 107
In pursuit of Irving and Scholander: a review of oxygen store management in seals and penguins
Ponganis, P. J., Meir, J. U., & Williams, C. L. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.031252 · Cited by 102
Maximal oxygen uptake is proportional to muscle fiber oxidative capacity, from chronic heart failure patients to professional cyclists
van der Zwaard, S., de Ruiter, C. J., Noordhof, D. A., Sterrenburg, R., Bloemers, F. W., de Koning, J. J., Jaspers, R. T., & van der Laarse, W. J. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00355.2016 · Cited by 103
EPR spectroscopic detection of free radical outflow from an isolated muscle bed in exercising humans
Bailey, D. M., Davies, B., Young, I. S., Jackson, M. J., Davison, G. W., Isaacson, R. A., & Richardson, R. S. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01024.2002 · Cited by 100
Self-citation
Increased V˙ o 2 maxwith right-shifted Hb-O2dissociation curve at a constant O2 delivery in dog muscle in situ
Richardson, R. S., Tagore, K. S., Haseler, L. J., Jordan, M. C., & Wagner, P. D. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.3.995 · Cited by 100
Self-citation
Genetic defects of cytochrome c oxidase assembly
Pecina, P., Houšt'ková, H., Zeman, J., & Houštěk, J. (2004) · Physiological Research · doi:10.33549/physiolres.930000.53.s213 · Cited by 100
US-China Education Review B
Santos, L. I. R., Alcoforado, L., & Cordeiro, A. M. R. (2024) · 美中教育评论：B · doi:10.17265/2161-6248 · Cited by 100
Increased expression of VEGF following exercise training in patients with heart failure
Gustafsson, T. P., Bodin, K., Sylvén, C., Gordon, A., Tyni‐Lenné, R., & Jansson, E. (2001) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2001.00816.x · Cited by 99
Oxygen gradients in the microcirculation
Pittman, R. N. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02232.x · Cited by 97
What limits performance during whole‐body incremental exercise to exhaustion in humans?
Morales‐Álamo, D., Losa‐Reyna, J., de Torres-Peralta, R. S., Martín-Rincón, M., Perez‐Valera, M., Curtelín, D., Ponce‐González, J. G., Santana, A., & Calbet, J. A. L. (2015) · The Journal of Physiology · doi:10.1113/jp270487 · Cited by 97
Invited Review: Adaptive responses of skeletal muscle to intermittent hypoxia: the known and the unknown
Clanton, T. L., & Klawitter, P. F. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2476 · Cited by 95
Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport?
Lundby, C., Robach, P., Boushel, R., Thomsen, J. J., Rasmussen, P., Koskolou, M. D., & Calbet, J. A. L. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90484.2008 · Cited by 95
NO-Rich Diet for Lifestyle-Related Diseases
Kobayashi, J., Ohtake, K., & Uchida, H. (2015) · Nutrients · doi:10.3390/nu7064911 · Cited by 94
Exercise limitations in heart failure with reduced and preserved ejection fraction
Poole, D. C., Richardson, R. S., Haykowsky, M. J., Hirai, D. M., & Musch, T. I. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00747.2017 · Cited by 100
Self-citation
Skeletal muscle oxidative metabolism in sedentary humans: 31P-MRS assessment of O2 supply and demand limitations
Haseler, L. J., Lin, A., & Richardson, R. S. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01321.2003 · Cited by 92
Self-citation
In vivo ATP production during free‐flow and ischaemic muscle contractions in humans
Lanza, I. R., Wigmore, D. M., Befroy, D. E., & Kent‐Braun, J. A. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.114249 · Cited by 91
Effect of contraction frequency on leg blood flow during knee extension exercise in humans
Hoelting, B. D., Scheuermann, B. W., & Barstow, T. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.2.671 · Cited by 91
Limitations to oxygen transport and utilization during sprint exercise in humans: evidence for a functional reserve in muscle O2 diffusing capacity
Calbet, J. A. L., Losa‐Reyna, J., de Torres-Peralta, R. S., Rasmussen, P. V., Ponce‐González, J. G., Sheel, A. W., Calle-Herrero, J. D. L., Guadalupe‐Grau, A., Morales‐Álamo, D., Fuentes, T., et al. (2015) · The Journal of Physiology · doi:10.1113/jp270408 · Cited by 89
VEGF-A splice variants and related receptor expression in human skeletal muscle following submaximal exercise
Gustafsson, T. P., Ameln, H., Fischer, H., Sundberg, C. J., Timmons, J. A., & Jansson, E. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01402.2004 · Cited by 88
Muscle mass and peripheral fatigue: a potential role for afferent feedback?
Rossman, M. J., Venturelli, M., McDaniel, J., Amann, M., & Richardson, R. S. (2012) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02471.x · Cited by 87
Self-citation
Local perfusion and metabolic demand during exercise: a noninvasive MRI method of assessment
Richardson, R. S., Haseler, L. J., Nygren, A., Blüml, S., & Frank, L. R. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.4.1845 · Cited by 87
Self-citation
Human skeletal muscle sympathetic nerve activity, heart rate and limb haemodynamics with reduced blood oxygenation and exercise
Hanada, A., Sander, M., & González‐Alonso, J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.044024 · Cited by 86
Energy sensing and regulation of gene expression in skeletal muscle
Freyssenet, D. G. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01126.2005 · Cited by 88
Mitochondria to motion: optimizing oxidative phosphorylation to improve exercise performance
Conley, K. E. (2016) · Journal of Experimental Biology · doi:10.1242/jeb.126623 · Cited by 85
Regulation of Myogenesis and Skeletal Muscle Regeneration: Effects of Oxygen Levels on Satellite Cell Activity
Chaillou1, T., & Lanner, J. T. (2016) · The FASEB Journal · doi:10.1096/fj.201600757r · Cited by 84
Effects of Beetroot Juice Supplementation on a 30-s High-Intensity Inertial Cycle Ergometer Test
Domínguez, R., Garnacho‐Castaño, M. V., Cuenca, E., García-Fernández, P., Muñoz-González, A., de Jesús, F., Lozano-Estevan, M. D. C., da Silva, S. F., Veiga-Herreros, P., & Maté‐Muñoz, J. L. (2017) · Nutrients · doi:10.3390/nu9121360 · Cited by 90
Exercise‐Induced Expression of Vascular Endothelial Growth Factor mRNA in Rat Skeletal Muscle is Dependent on Fibre Type
Birot, O., Koulmann, N., Peinnequin, A., & Bigard, X. A. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.043026 · Cited by 88
Energy metabolism design of the striated muscle cell
Glancy, B. C., & Balaban, R. S. (2021) · Physiological Reviews · doi:10.1152/physrev.00040.2020 · Cited by 86
The critical role of VEGF in skeletal muscle angiogenesis and blood flow
Wagner, P. D. (2011) · Biochemical Society Transactions · doi:10.1042/bst20110646 · Cited by 81
Self-citation
Oxygenation Threshold Derived from Near-Infrared Spectroscopy: Reliability and Its Relationship with the First Ventilatory Threshold
van der Zwaard, S., Jaspers, R. T., Blokland, I. J., Achterberg, C., Visser, J. M., den Uil, A. R., Hofmijster, M. J., Levels, K., Noordhof, D. A., de Haan, A., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0162914 · Cited by 80
Skeletal Muscle Fiber Type in Hypoxia: Adaptation to High-Altitude Exposure and Under Conditions of Pathological Hypoxia
Chaillou, T. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01450 · Cited by 80
Oxygen and the Upper Limits to Animal Design and Performance
Suarez, R. K. (1998) · Journal of Experimental Biology · doi:10.1242/jeb.201.8.1065 · Cited by 79
Comparison of femoral blood gases and muscle near-infrared spectroscopy at exercise onset in humans
MacDonald, M. J., Tarnopolsky, M. A., Green, H. J., & Hughson, R. L. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.2.687 · Cited by 98
Oxygen uptake kinetics: historical perspective and future directions
Hughson, R. L. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-088 · Cited by 77
Muscle blood flow and oxygenation measured by NMR imaging and spectroscopy
Carlier, P. G., Bertoldi, D., Baligand, C., Wary, C., & Fromes, Y. (2006) · NMR in Biomedicine · doi:10.1002/nbm.1081 · Cited by 76
Coenzyme Q10 supplementation ameliorates inflammatory signaling and oxidative stress associated with strenuous exercise
Díaz‐Castro, J., Guisado, R., Kajarabille, N., García, C., Guisado-Requena, I. M., de Teresa, C., & Ochoa, J. J. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0257-5 · Cited by 75
The effect of hypoxia on pulmonary O2 uptake, leg blood flow and muscle deoxygenation during single‐leg knee‐extension exercise
DeLorey, D. S., Shaw, C. N., Shoemaker, J. K., Kowalchuk, J. M., & Paterson, D. H. (2004) · Experimental Physiology · doi:10.1113/expphysiol.2003.026864 · Cited by 74
Diffusive resistance to O2 transport in muscle
Wagner, P. D. (2000) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2000.00712.x · Cited by 74
Self-citation
ATP as a mediator of erythrocyte‐dependent regulation of skeletal muscle blood flow and oxygen delivery in humans
González‐Alonso, J. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.235002 · Cited by 73
Skeletal muscle angiogenesis
Wagner, P. D. (2001) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-3401-0_4 · Cited by 73
Self-citation
Blood Flow Restricted Exercise and Vascular Function
Horiuchi, M., & Okita, K. (2012) · International Journal of Vascular Medicine · doi:10.1155/2012/543218 · Cited by 75
Modeling oxygenation in venous blood and skeletal muscle in response to exercise using near-infrared spectroscopy
Lai, N., Zhou, H., Saidel, G. M., Wolf, M., McCully, K. K., Gladden, L. B., & Cabrera, M. E. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91102.2008 · Cited by 74
Oxygen delivery does not limit cardiac performance during high work states
Zhang, J. J., Murakami, Y., Zhang, Y., Cho, Y. K., Ye, Y., Gong, G., Bache, R. J., Uǧurbil, K., & From, A. H. L. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.1.h50 · Cited by 72
Phosphorescence quenching method for measurement of intracellular P O 2 in isolated skeletal muscle fibers
Hogan, M. C. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.2.720 · Cited by 71
What triggers the aerobic dive limit? Patterns of muscle oxygen depletion during dives of emperor penguins
Williams, C. L., Meir, J. U., & Ponganis, P. J. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.052233 · Cited by 71
Mitochondrial respiration in the low oxygen environment of the cell effect of ADP on oxygen kinetics
Gnaiger, E., Lassnig, B., Kuznetsov, A. V., & Margreiter, R. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00076-0 · Cited by 71
Microscopic model of carbon monoxide binding to myoglobin
McMahon, B. H., Stojković, B. P., Hay, P. J., Martin, R. L., & Garcı́a, A. E. (2000) · The Journal of Chemical Physics · doi:10.1063/1.1309524 · Cited by 71
HIF and VEGF relationships in response to hypoxia and sciatic nerve stimulation in rat gastrocnemius
Tang, K., Breen, E. C., Wagner, H. E., Brutsaert, T. D., Gassmann, M., & Wagner, P. D. (2004) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2004.04.009 · Cited by 71
Self-citation
Physiological Function during Exercise and Environmental Stress in Humans—An Integrative View of Body Systems and Homeostasis
Travers, G. J. S., Kippelen, P., Trangmar, S. J., & González‐Alonso, J. (2022) · Cells · doi:10.3390/cells11030383 · Cited by 74
Skeletal muscle metabolism in individuals with spinal cord injury
McCully, K. K., Mulcahy, T. K., RYAN, T. E., & Zhao, Q. C. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00094.2011 · Cited by 70
Telomeres Shorten in Response to Oxidative Stress in Mouse Skeletal Muscle Fibers
Ludlow, A. T., Spangenburg, E. E., Chin, E. R., Cheng, W., & Roth, S. M. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt211 · Cited by 71
Metabolic and vascular support for the role of myoglobin in humans: a multiparametric NMR study
Duteil, S., Bourrilhon, C., Raynaud, J. S., Wary, C., Richardson, R. S., Leroy‐Willig, A., Jouanin, J., Guezennec, C. Y., & Carlier, P. G. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00242.2004 · Cited by 70
Self-citation
The role of vascular function on exercise capacity in health and disease
Poole, D. C., Behnke, B. J., & Musch, T. I. (2020) · The Journal of Physiology · doi:10.1113/jp278931 · Cited by 77
Chronic hypoxia attenuates resting and exercise-induced VEGF, flt-1, and flk-1 mRNA levels in skeletal muscle
Olfert, I. M., Breen, E. C., Mathieu-Costello, O. A., & Wagner, P. D. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.4.1532 · Cited by 68
Self-citation
Kinetic control of oxygen consumption during contractions in self‐perfused skeletal muscle
Wüst, R. C. I., Grassi, B., Hogan, M. C., Howlett, R. A., Gladden, L. B., & Rossiter, H. B. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.203422 · Cited by 69
Dietary nitrate supplementation enhances short but not longer duration running time-trial performance
Shannon, O. M., Barlow, M., Duckworth, L. C., Williams, E. L., Wort, G. K., Woods, D. R., Siervo, M., & O'Hara, J. P. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3580-6 · Cited by 73
Slow $$ \dot{V}{\text{O}}_{2} $$ kinetics during moderate-intensity exercise as markers of lower metabolic stability and lower exercise tolerance
Grassi, B., Porcelli, S., Salvadego, D., & Zoladz, J. A. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1609-1 · Cited by 68
HIF-hypoxia signaling in skeletal muscle physiology and fibrosis
Valle-Tenney, R., Rebolledo, D. L., Acuña, M. J., & Brandan, E. (2020) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-020-00553-8 · Cited by 70
Oxygen supply to contracting skeletal muscle at the microcirculatory level: diffusion vs. convection
Pittman, R. N. (2000) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2000.00710.x · Cited by 67
Training with blood flow restriction increases femoral artery diameter and thigh oxygen delivery during knee‐extensor exercise in recreationally trained men
Christiansen, D., Eibye, K., Hostrup, M., & Bangsbo, J. (2020) · The Journal of Physiology · doi:10.1113/jp279554 · Cited by 67
The Role of Hif-1 1 in Hypoxic Response in the Skeletal Muscle
Mason, S. D., & Johnson, R. S. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-75434-5_18 · Cited by 65
A hypoxia complement differentiates the muscle response to endurance exercise
Schmutz, S., Däpp, C., Wittwer, M., Durieux, A., Müeller, M., Weinstein, F. V., Vogt, M., Hoppeler, H. H., & Flück, M. (2010) · Experimental Physiology · doi:10.1113/expphysiol.2009.051029 · Cited by 66
Estimation of capillary density in human skeletal muscle based on maximal oxygen consumption rates
McGuire, B. J., & Secomb, T. W. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00559.2003 · Cited by 64
Oxygen affinity and amino acid sequence of myoglobins from endothermic and ectothermic fish
Marcinek, D. J., Bonaventura, J., Wittenberg, J. B., & Block, B. A. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.4.r1123 · Cited by 66
Effects of FIO2 on leg ??VO2 during cycle ergometry in sedentary subjects
S, J. C., Marrades, R. M., Roca, J., Barberà, J. A., Orlando Díaz, P., Masclans, J. R., Rodriguez‐Roisin, R., & Wagner, P. D. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199805000-00009 · Cited by 66
Self-citation
Plasticity of the Muscle Proteome to Exercise at Altitude
Flueck, M. (2009) · High Altitude Medicine & Biology · doi:10.1089/ham.2008.1104 · Cited by 65
Continued divergence in V o 2 max of rats artificially selected for running endurance is mediated by greater convective blood O 2 delivery
González, N. C., Kirkton, S. D., Howlett, R. A., Britton, S. L., Koch, L. G., Wagner, H. E., & Wagner, P. D. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01527.2005 · Cited by 61
Self-citation
Aging attenuates vascular and metabolic plasticity but does not limit improvement in muscle V o 2 max
Lawrenson, L., Hoff, J., & Richardson, R. S. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01070.2003 · Cited by 62
Self-citation
Oxygen—A Key Regulatory Metabolite in Metabolic Defense Against Hypoxia
Hochachka, P. W. (1997) · American Zoologist · doi:10.1093/icb/37.6.595 · Cited by 64
A common haplotype and the Pro582Ser polymorphism of the hypoxia-inducible factor-1α (HIF1A) gene in elite endurance athletes
Döring, F., Onur, S., Fischer, A., Boulay, M. R., Përusse, L., Rankinen, T., Rauramaa, R., Wolfarth, B., & Bouchard, C. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01165.2009 · Cited by 67
Hypoxia inducible factor 1α links fast‐patterned muscle activity and fast muscle phenotype in rats
Lunde, I. G., Anton, S., Bruusgaard, J. C., Rana, Z. A., Ellefsen, S., & Gundersen, K. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.202762 · Cited by 62
Maximal oxygen consumption in healthy humans: theories and facts
Ferretti, G. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2911-0 · Cited by 63
Influence of blood flow occlusion on muscle oxygenation characteristics and the parameters of the power-duration relationship
Broxterman, R. M., Ade, C. J., Craig, J. C., Wilcox, S. L., Schlup, S. J., & Barstow, T. J. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00875.2014 · Cited by 61
Regulation of skeletal muscle capillary growth in exercise and disease
Haas, T. L., & Nwadozi, E. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0336 · Cited by 57
Mitochondrial Function in Flying Honeybees (Apis Mellifera): Respiratory Chain Enzymes and Electron Flow from Complex III to Oxygen
Suarez, R. K., Staples, J. F., Lighton, J. R. B., & Mathieu-Costello, O. A. (2000) · Journal of Experimental Biology · doi:10.1242/jeb.203.5.905 · Cited by 61
Muscle oxygen uptake in humans at onset of and during intense exercise
Bangsbo, J. (2000) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2000.00697.x · Cited by 61
Myoglobin: Just an Oxygen Store or Also an Oxygen Transporter?
Jürgens, K. D., Papadopoulos, S., Peters, T. T. A., & Gros, G. (2000) · Physiology · doi:10.1152/physiologyonline.2000.15.5.269 · Cited by 61
Near‐infrared spectroscopy estimation of combined skeletal muscle oxidative capacity and O2 diffusion capacity in humans
Pilotto, A., Adami, A., Mazzolari, R., Brocca, L., Crea, E., Zuccarelli, L., Pellegrino, M. A., Bottinelli, R., Grassi, B., Rossiter, H. B., et al. (2022) · The Journal of Physiology · doi:10.1113/jp283267 · Cited by 60
Skeletal muscle microvascular and interstitial from rest to contractions
Hirai, D. M., Craig, J. C., Colburn, T. D., Eshima, H., Kano, Y., Sexton, W. L., Musch, T. I., & Poole, D. C. (2017) · The Journal of Physiology · doi:10.1113/jp275170 · Cited by 60
August Krogh's theory of muscle microvascular control and oxygen delivery: a paradigm shift based on new data
Poole, D. C., Pittman, R. N., Musch, T. I., & Østergaard, L. (2020) · The Journal of Physiology · doi:10.1113/jp279223 · Cited by 57

Authors: Richardson, R. S., Noyszewski, E. A., Kendrick, K. F., Leigh, J. S., & Wagner, P. D.
Affiliations: University of California System (US)
ORCID: Richardson, R S
Wagner, P D
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1995-10-01
Volume: 96
Issue: 4
Pages: 1916-1926
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci118237
PMC: PMC185828
OpenAlex: W2074243670
Cited by: 647
References: 47
Citations by year: 2026: 19 · 2025: 16 · 2024: 29 · 2023: 27 · 2022: 16 · 2021: 19 · 2020: 28 · 2019: 23 · 2018: 20 · 2017: 26 · 2016: 14 · 2015: 31 · 2014: 19 · 2013: 21 · 2012: 24
FWCI: 27.28
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Tobacco-Related Disease Research Program
National Heart, Lung, and Blood Institute (R01HL044125, HL 44125, P01HL017731, HL17731)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Health Sciences › Medicine › Physiology (medical) › High Altitude and Hypoxia
Keywords: oxygen transport, physical activity, hypoxia, capillary oxygen tension, muscle oxygenation, oxygen diffusion limitation, VO2max, quadriceps, arterial oxygen tension, 1H NMR, trained men
MeSH terms: Adult, Biological Transport, Humans, Hydrogen-Ion Concentration, Leg, Male, Muscles, Myoglobin, Oxygen, Oxygen Consumption, Exercise, Cell Respiration

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Myoglobin O2 desaturation during exercise. Evidence of limited O2 transport.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks