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Cited by 75Cardiovascular and exercise physiologyCardiovascular Health and Disease PreventionPhysical Activity and Health

Blood Flow Restricted Exercise and Vascular Function

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Horiuchi, Masahiro, Okita, Koichi·2012·International Journal of Vascular Medicine
DOI 10.1155/2012/543218PMC PMC3485988
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Abstract

It is established that regular aerobic training improves vascular function, for example, endothelium-dependent vasodilatation and arterial stiffness or compliance and thereby constitutes a preventative measure against cardiovascular disease. In contrast, high-intensity resistance training impairs vascular function, while the influence of moderate-intensity resistance training on vascular function is still controversial. However, aerobic training is insufficient to inhibit loss in muscular strength with advancing age; thus, resistance training is recommended to prevent sarcopenia. Recently, several lines of study have provided compelling data showing that exercise and training with blood flow restriction (BFR) leads to muscle hypertrophy and strength increase. As such, BFR training might be a novel means of overcoming the contradiction between aerobic and high-intensity resistance training. Although it is not enough evidence to obtain consensus about impact of BFR training on vascular function, available evidences suggested that BFR training did not change coagulation factors and arterial compliance though with inconsistence results in endothelial function. This paper is a review of the literature on the impact of BFR exercise and training on vascular function, such as endothelial function, arterial compliance, or other potential factors in comparison with those of aerobic and resistance training.

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  • These findings should be interpreted as evidence of vascular organization and arterial-/venous-associated endothelial features rather than complete vascular hierarchy maturation.

    “Thus, these findings should be interpreted as evidence of vascular organization and arterial-/venous-associated endothelial features rather than complete vascular hierarchy maturation 49 .”

    From Vascularized human skin assembloids model compartmental skin organization and immune responsiveness in vitro (2026) · cites this paper as [49]

    Section 2.4, “Flow Mediated Dilation” (page unavailable), discusses endothelial function as assessed by arterial dilation, not arterial- and venous-associated endothelial features or vascular hierarchy maturation. Searches for vascular organization, arterial/venous markers, and hierarchy maturation found no passage addressing the claimed distinction. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Horiuchi, M., & Okita, K.
Affiliations
Hokusho University (JP)
Corresponding author
Horiuchi, Masahiro
ORCID
Venue
International Journal of Vascular Medicine
Publisher
Wiley
Published
2012
Volume
2012
Pages
1-17
ISSN
  • 2090-2824 (ISSN-L)
  • 2090-2832
DOI
10.1155/2012/543218
PMC
PMC3485988
OpenAlex
W2155778431
Cited by
75
References
12
Citations by year
2026: 3 · 2025: 5 · 2024: 7 · 2023: 11 · 2022: 9 · 2021: 12 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 1 · 2016: 3 · 2015: 2 · 2013: 2
FWCI
2.99
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Vascular Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology (23500784)
  • Japan Society for the Promotion of Science (23500784)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords
blood flow restriction, vascular function, endothelial function, arterial compliance, arterial stiffness, aerobic exercise, resistance training, muscle hypertrophy, sarcopenia, cardiovascular disease prevention, coagulation factors

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