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Glucose transport in cultured human skeletal muscle cells. Regulation by insulin and glucose in nondiabetic and non-insulin-dependent diabetes mellitus subjects
Open accessAbstract
A primary human skeletal muscle culture (HSMC) system, which retains cellular integrity and insulin responsiveness for glucose transport was employed to evaluate glucose transport regulation. As previously reported, cells cultured from non-insulin-dependent diabetic (NIDDM) subjects displayed significant reductions in both basal and acute insulin-stimulated transport compared to nondiabetic controls (NC). Fusion/differentiation of NC and NIDDM HSMC in elevated media insulin (from 22 pM to 30 microM) resulted in increased basal transport activities but reduced insulin-stimulated transport, so that cells were no longer insulin responsive. After fusion under hyperinsulinemic conditions, GLUT1 protein expression was elevated in both groups while GLUT4 protein level was unaltered. Fusion of HSMC under hyperglycemic conditions (10 and 20 mM) decreased glucose transport in NC cells only when combined with hyperinsulinemia. Hyperglycemia alone down-regulated transport in HSMC of NIDDM, while the combination of hyperglycemia and hyperinsulinemia had greater effects. In summary: (a) insulin resistance of glucose transport can be induced in HSMC of both NC and NIDDM by hyperinsulinemia and is accompanied by unaltered GLUT4 but increased GLUT1 levels; and (b) HSMC from NIDDM subjects demonstrate an increased sensitivity to impairment of glucose transport by hyperglycemia. These results indicate that insulin resistance in skeletal muscle can be acquired in NC and NIDDM from hyperinsulinemia alone but that NIDDM is uniquely sensitive to the additional influence of hyperglycemia.
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“Insulin-mediated translocation of GLUT4 to the muscle sarcolemmal membrane was impaired in patients with type 2 diabetes mellitus.24,25”
From Lipid-induced insulin resistance: unravelling the mechanism (2010) · cites this paper as [24]
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Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Towbin, H., Staehelin, T., & Gordon, J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4350 · Cited by 53,218
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,311
The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM
DeFronzo, R. A. (1988) · Diabetes · doi:10.2337/diab.37.6.667 · Cited by 2,456
Facilitative glucose transporters
Mueckler, M. M. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb18550.x · Cited by 1,092
Isolation and characterization of human muscle cells.
Blau, H. M., & Webster, C. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.9.5623 · Cited by 402
Holman, G. D., Kozka, I. J., CLARK, A. E., Flower, C. J., Saltis, J., Habberfield, A. D., Simpson, I. A., & Cushman, S. W. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44734-x · Cited by 329
Pedersen, O., Bak, J. F., Andersen, P. H., Lund, S., Moller, D. E., Flier, J. S., & Kahn, B. B. (1990) · Diabetes · doi:10.2337/diab.39.7.865 · Cited by 329
Del Prato, S., Leonetti, F., Simonson, D. C., Sheehan, P., Matsuda, M., & DeFronzo, R. A. (1994) · Diabetologia · doi:10.1007/bf00400466 · Cited by 322
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Fibre Type Dependent Expression of Glucose Transporters in Human Skeletal Muscles
Gaster, M. (2007) · Apmis · doi:10.1111/j.1600-0463.2007.apm_v115_s121.x · Cited by 5
Pathogenesis of Type 2 Diabetes
Cusi, K. J., & DeFronzo, R. A. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070237 · Cited by 5
Exogenous detection of 13C-glucose metabolism in tumor and diet-induced obesity models
Verlande, A., Chun, S. K., Song, W. A., Oettler, D., Knot, H. J., & Masri, S. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1023614 · Cited by 4
Chalfant, C. E. (2000) · Endocrinology · doi:10.1210/en.141.8.2773 · Cited by 4
Cen, H. H., Botezelli, J. D., Wang, S., Noursadeghi, N., Jessen, N., Timmons, J. A., & Johnson, J. D. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/556571 · Cited by 4
THE ROLE OF MACROPHAGES IN EXERCISE AND INSULIN RESISTANCE IN HUMAN SKELETAL MUSCLE
Groshong, J. S. (2013) · UKnowledge (University of Kentucky) · Cited by 2
Fahrner, A., Laiferová, N. A., Ukropcová, B., Ukropec, J., & Krützfeldt, J. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad041 · Cited by 1
Yamada, T., Miyake, T., Sugiura, K., Narita, A., Wei, K., Wei, S., Moralejo, D. H., Ogino, T., GAILLARD, C., Sasaki, Y., et al. (2001) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.50.115 · Cited by 2
Tajik, A., Mahdavizadeh, V., Hadizadeh, F., & Shakour, N. (2025) · Current Diabetes Reviews · doi:10.2174/0115733998349193250207045239 · Cited by 1
Sundaram, C. (2012) · InTech eBooks · doi:10.5772/1241 · Cited by 1
Insulin Resistance and Inhibitors of the Insulin Receptor Tyrosine Kinase
YOUNGREN, J. F. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-116-5_15 · Cited by 1
Hjelle, L. (2011) · NORA - Norwegian Open Research Archives
Endocannabinoids and skeletal muscle glucose uptake.
Cavuoto, P. (2010) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
skeletal muscle cells: rate-limiting steps Glucose uptake and metabolism by cultured human
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Cen, H. H. (2021) · cIRcle (University of British Columbia) · doi:10.14288/1.0401784
Faculty Opinions recommendation of The barrier within: endothelial transport of hormones.
Chessler, S. D. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717955651.793460652
Suárez‐Cuenca, J. A., Carvajal, K., Camacho, L., la Vega-Moreno, K. D., Romero-Hernández, C. B., Vera‐Gómez, E., Hernández‐Patricio, A., Domínguez-Pérez, G. A., Gutiérrez-Buendía, J. A., Montiel-López, L., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1390398/v1
Liu, N., Wang, L., Xing, Y., & Wang, C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.26.525692
Pathogenesis of Type 2 Diabetes
Cusi, K. J., & DeFronzo, R. A. (2001) · Comprehensive physiology · doi:10.1002/j.2040-4603.2001.tb01483.x
Homéostasie des céramides et hépatopathies métaboliques
Régnier, M. (2018) · theses.fr (ABES) · doi:10.70675/2fb92711z373cz4b27z8082z7aa3f8930e63
Metadata
- Authors
- Ciaraldi, T. P., Abrams, L., Nikoulina, S., Mudaliar, S., & Henry, R. R.
- Affiliations
- Veterans Health Administration (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1995-12-01
- Volume
- 96
- Issue
- 6
- Pages
- 2820-2827
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC185992
- OpenAlex
- W2060118222
- Cited by
- 124
- References
- 50
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 7 · 2012: 9
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- U.S. Department of Veterans Affairs
- American Heart Association
- National Institutes of Health (5r29dk038949-05)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 38949)
- National Center for Research Resources (MO1 RR00827, M01RR000827)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- glucose transport, skeletal muscle cells, insulin resistance, type 2 diabetes, hyperinsulinemia, hyperglycemia, GLUT1, GLUT4, insulin-stimulated glucose transport, cell fusion
- MeSH terms
- Adult, Biopsy, Cell Differentiation, Cell Fusion, Cell Membrane, Cells, Cultured, Diabetes Mellitus, Type 2, Glucose, Humans, Hyperglycemia, Hyperinsulinism, Insulin, Middle Aged, Monosaccharide Transport Proteins, Muscle Proteins, Reference Values, Muscle, Skeletal, Glucose Transporter Type 1, Glucose Transporter Type 4
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