Cited by 593Atherosclerosis and Cardiovascular DiseasesNeutrophil, Myeloperoxidase and Oxidative MechanismsNitric Oxide and Endothelin Effects

The DOI matches its Crossref record; 37 of the 39 references it cites were found in a registry or an index.

Presence of hypochlorite-modified proteins in human atherosclerotic lesions.

Open access

Hazell, L J, Arnold, L, Flowers, D, Waeg, G, Malle, E, Stocker, R·1996·Journal of Clinical Investigation

DOI 10.1172/jci118576PMC PMC507214

Open this paper in CoChat — free account Open PDF

Abstract

Oxidation of LDL may contribute to atherogenesis, though the nature of the in vivo oxidant(s) remains obscure. Myeloperoxidase, the enzyme responsible for hypochlorous acid/hypochlorite (HOCl) production in vivo, is present in active form in human atherosclerotic lesions, and HOCl aggregates and transforms LDL into a high-uptake form for macrophages in vitro. Here we demonstrate HOCl-modified proteins in human lesions using an mAb raised against HOCl-modified LDL that recognizes HOCl-oxidized proteins but does not cross-react with Cu2+-, malondialdehyde-, or 4-hydroxynonenal-modified LDL. This antibody detected significantly more material in advanced atherosclerotic lesions than normal arteries, even though azide and methionine were included during sample work-up to inhibit myeloperoxidase and to scavenge HOCl. The epitope(s) recognized was predominantly cell associated and present in monocyte/macrophages, smooth muscle, and endothelial cells. The intima and cholesterol clefts stained more heavily than the center of the thickened vessels; adventitial staining was apparent in some cases. Immunostaining was also detected in a very early lesion from an accident victim, beside healthy areas that were unreactive. LDL oxidized by HOCl in vitro, but not native LDL, effectively competed with the epitopes in lesions for antibody binding. Density centrifugation of plaque homogenates and Western blot analysis showed that, in the apo B-containing lipoprotein fraction, the mAb recognized protein(s) of molecular mass greater than apo B, similar to those produced during oxidation of LDL with HOCl in vitro. Three major proteins were recognized by the anti-HOCl-modified protein antibody but not by an anti-apo B antibody in the apo B-free fraction. Together, these results demonstrate HOCl-oxidized proteins in human atherosclerotic lesions, implicating this oxidant in LDL modification in vivo.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci118576

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Measurement of protein using bicinchoninic acid
Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., & Klenk, D. C. (1985) · Analytical Biochemistry · doi:10.1016/0003-2697(85)90442-7 · Cited by 18,482
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618
Theory and Practice of Histological Techniques
Bancroft, J. D., & Gamble, M. (1990) · Cited by 6,948
Beyond Cholesterol
Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425
Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.
Ylä‐Herttuala, S., Palinski, W., Rosenfeld, M. E., Parthasarathy, S., Carew, T. E., Butler, S. S., Witztum, J. L., & Steinberg, D. H. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114271 · Cited by 1,877
Low density lipoprotein undergoes oxidative modification in vivo.
Palinski, W., Rosenfeld, M. E., Ylä‐Herttuala, S., Gurtner, G. C., Socher, S. S., Butler, S. W., Parthasarathy, S., Carew, T. E., Steinberg, D. H., & Witztum, J. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.4.1372 · Cited by 1,514
The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.
Rg, G. (1981) · PubMed Central · Cited by 1,314
A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.
Stary, H. C., Chandler, A. B., Glagov, S. K., Guyton, J. R., Insull, W., Rosenfeld, M. E., Schaffer, S. A., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1994) · Circulation · doi:10.1161/01.cir.89.5.2462 · Cited by 1,313
Autoantibody against oxidised LDL and progression of carotid atherosclerosis
Salonen, J. T., Korpela, H., Salonen, R., Nyyssönen, K., Ylä‐Herttuala, S., Yamamoto, R., Butler, S., Palinski, W., & Witztum, J. L. (1992) · The Lancet · doi:10.1016/0140-6736(92)90926-t · Cited by 1,311
Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.
Daugherty, A., Dunn, J. L., Rateri, D. L., & Heinecke, J. W. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117342 · Cited by 1,269

Show all 39 references

Research works printed but not linked: 1

Adams, D.O., and T.A. Hamilton. 1992. Macrophages as destructive cells in host defense. In Inflammation: Basic principles and clinical correlates. J.I. Gallin, I.M. Goldstein, and R. Snyderman. Raven Press, New York. 637- 662.

Sorted by citations

Items 501–593 of 593

Myeloperoxidase: Structure and Function of the Green Heme Peroxidase of Neutrophils
Kettle, A. J., & Winterbourn, C. C. (2015) · Royal Society of Chemistry eBooks · doi:10.1039/9781782622628-00272 · Cited by 7
Other forms of oxidized LDL: Emerging functions (Review)
Daher, J. (2020) · World Academy of Sciences Journal · doi:10.3892/wasj.2020.45 · Cited by 7
Myeloperoxidase evokes substantial vasomotor responses in isolated skeletal muscle arterioles of the rat
Csató, V., Pető, A., Fülöp, G. Á., Rutkai, I., Pásztor, E. T., Fagyas, M., Kalász, J., Edes, I. F., Tóth, A., & Papp, Z. (2015) · Acta Physiologica · doi:10.1111/apha.12488 · Cited by 6
Intimal plaque development and oxidative stress in cholesterol‐induced atherosclerosis in New Zealand rabbits
Heinle, H., Brehme, U., Friedemann, G., Frey, J. ‐., Wolf, A. T., Kelber, O., Weiser, D., Schmahl, F. W., Lang, F. J. W., & Schneider, W. (2002) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2002.01024.x · Cited by 7
Hypochlorite-induced damage to red blood cells: evidence for the formation of nitrogen-centred radicals
Hawkins, C. L., & Davies, M. J. (2000) · Redox Report · doi:10.1179/rer.2000.5.1.57 · Cited by 7
Oxidative Stress and Protein Oxidation
Grune, T., Catalgol, B., & Jung, T. (2012) · Wiley eBooks · doi:10.1002/9781118493038.ch1 · Cited by 7
Vascular Oxidative Stress and Antioxidant Protection in Atherosclerosis
Keaney, J. F., & Vita, J. A. (2002) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200207000-00003 · Cited by 7
Effects of Differently Oxidized LDL on the Expression of Pro-Inflammatory Molecules in Human Monocytes In Vitro
Dominaitiene, R., Lindgren, S. C., & Janciauskiene, S. M. (2001) · In Vitro & Molecular Toxicology · doi:10.1089/10979330152560487 · Cited by 7
Reactive Halogen Species: Role in Living Systems and Current Research Approaches
Khramova, Y. V., Katrukha, V. A., Chebanenko, V. V., Kostyuk, A. I., Gorbunov, N., Panasenko, O. M., Av, S., & Bilan, D. S. (2024) · Biochemistry (Moscow) · doi:10.1134/s0006297924140062 · Cited by 6
Products of the reaction of HOCl with tryptophan protect LDL from atherogenic modification
Kapiotis, S., Jirovetz, L., Hermann, M., Laggner, H., Exner, M., Esterbauer, H., & Gmeiner, B. M. K. (2006) · Biochimie · doi:10.1016/j.biochi.2006.01.006 · Cited by 6
Development of a lysosome-targeted iridium (III) complex-based fluorescent probe for detection of HOCl and its application in living cells and water samples
Mao, X., Xu, S., Wu, C., Fan, C., Zhang, D., & Pu, S. (2023) · Inorganica Chimica Acta · doi:10.1016/j.ica.2023.121634 · Cited by 5
Myeloperoxidase gene sequence variations are associated with low-density-lipoprotein characteristics
Dolley, G., Lamarche, B., Després, J., Bouchard, C., Përusse, L., & Vohl, M. (2008) · Journal of Human Genetics · doi:10.1007/s10038-008-0267-1 · Cited by 6
Water-soluble poly(p-phenylene) incorporating methoxyphenol units: Highly sensitive and selective chemodosimeters for hypochlorite
Zhang, W., Li, C., Qin, J., & Yang, C. (2012) · Polymer · doi:10.1016/j.polymer.2012.03.063 · Cited by 6
Genesis of Atherosclerosis in Uremic Patients
Drüeke, T. B. (1999) · Mineral and Electrolyte Metabolism · doi:10.1159/000057456 · Cited by 6
Reduction of transition metals by human (THP-1) monocytes is enhanced by activators of protein kinase C
Wood, J. L., & Graham, A. (1999) · Free Radical Research · doi:10.1080/10715769900300941 · Cited by 6
A monoclonal antibody recognizing the chlorohydrin derivatives of oleic acid for probing hypochlorous acid involvement in tissue injury
Domigan, N. M., Carr, A. C., Lewis, J. G., Elder, P. A., & Winterbourn, C. C. (1997) · Redox Report · doi:10.1080/13510002.1997.11747097 · Cited by 6
Hypochlorous Acid and Chloramines Induce Specific Fragmentation and Cross-Linking of the G1-IGD-G2 Domains of Recombinant Human Aggrecan, and Inhibit ADAMTS1 Activity
Wang, Y., Hammer, A., Höefler, G., Malle, E., Hawkins, C. L., Chuang, C. Y., & Davies, M. J. (2023) · Antioxidants · doi:10.3390/antiox12020420 · Cited by 5
Self-citation
Contemporary Scientific Insights
Jialal, I. (2006) · Critical Pathways in Cardiology A Journal of Evidence-Based Medicine · doi:10.1097/01.hpc.0000248966.42773.ca · Cited by 5
Oxidation of cysteine by ceruloplasmin leads to formation of hydrogen peroxide, which can be utilized by myeloperoxidase
Kostevich, V. A., & Av, S. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.08.003 · Cited by 5
Ruthenium(II) Complex‐based Highly Specific Luminescence Light‐up Probe for Detecting HOCl via C(sp 2 )‐H Chlorination
Rabha, M., Sheet, S. K., Sen, B., Konthoujam, I., Aguan, K., & Khatua, S. (2023) · ChemistrySelect · doi:10.1002/slct.202204643 · Cited by 5
Imaging Myeloperoxidase Activity in Cardiovascular Disease
Ronald, J. A. (2010) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-010-9056-2 · Cited by 5
Graphene oxide based ratiometric fluorescent paper sensor for hypochlorous acid visual detection
Yang, C., Feng, W., Li, Y., Tian, X., Zhou, Z., Lu, L., & Nie, Y. (2019) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2019.02.021 · Cited by 5
The content of lipoperoxidation products in normal and atherosclerotic human aorta
Tertov, V. V., Kaplun, V. V., Михайлова, И. А., Suprun, I. V., & Orekhov, A. N. (2001) · Molecular and Cellular Biochemistry · doi:10.1023/a:1012267520932 · Cited by 5
Water‐soluble fluorene‐based copolymers incorporated methoxyphenol moieties: Novel polymeric chemodosimeters for hypochlorous acid
Zhang, W., Liu, L., Liu, L., Qin, J., & Yang, C. (2011) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.25878 · Cited by 5
A ratiometric and rapid-response fluorescent nanoprobe based on modification of carbon quantum dots by naphthalimide for HClO bioimaging in living cells and mice
Xu, K., Liang, R., Ye, Z., & Gao, Y. (2025) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2025.126321 · Cited by 4
Rationale for a novel nutraceutical complex ‘K-water’: Potassium taurine bicarbonate (PTB)
McCarty, M. F. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2005.09.056 · Cited by 4
Pulmonary Autoimmunity and Inflammation
Jeitner, T. M., & Lawrence, D. A. (2000) · Springer eBooks · doi:10.1007/978-1-4615-4535-4_6 · Cited by 4
Mechanisms of Antioxidant Action of Ubiquinol-10 for Low-Density Lipoprotein
Stocker, R., & Thomas, S. R. (2000) · Modern nutrition · doi:10.1201/9781420036701.ch9 · Cited by 4
Self-citation
Atherosclerosis, Oxidative Stress, and Endothelial Function
Keaney, J. F. (2000) · Developments in cardiovascular medicine · doi:10.1007/978-1-4615-4649-8_9 · Cited by 4
Endogenous and exogenous antioxidants and the generation of antigenic epitopes in oxidatively‐modified LDL
Bellomo, G., Maggi, E., Seccia, M., Palladini, G., & Perugini, C. (1997) · BioFactors · doi:10.1002/biof.5520060202 · Cited by 4
Molecular magnetic resonance imaging of myeloperoxidase activity identifies culprit lesions and predicts future atherothrombosis
Nadel, J., Wang, X., Saha, P., Bongers, A., Tumanov, S., Giannotti, N., Chen, W., Vigder, N., Chowdhury, M. M., da Cruz, G. J. L., et al. (2024) · European Heart Journal - Imaging Methods and Practice · doi:10.1093/ehjimp/qyae004 · Cited by 3
Self-citation
Chemiluminescent Hydrogen Peroxide Sensor Based on Luminol and a Colloidal Solution of Metal Nanoparticles
Virts, N. A., Dadadzhanov, D. R., Yablokov, A. S., Shershnev, D. V., & Vartanyan, T. A. (2024) · Optics and Spectroscopy · doi:10.1134/s0030400x24020188 · Cited by 3
Structural and Functional Impacts of Albumin Oxidation by Hypochlorite: Possible Changes in Drug Binding Characteristics upon Myeloperoxidase-Mediated Oxidation In Vivo
Ashrafi-Kooshk, M. R., Khodarahmi‬, R., Karimi, S. A., & Nikbakht, M. R. (2013) · doi:10.22110/jrps.v1i2.905 · Cited by 3
Functional Change in the HDL Particle by Oxidative Modification and its Contribution to Atherogenesis
Matsunaga, T., Hara, A., & Komoda, T. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-382171-3.10011-7 · Cited by 3
Inflammation in coronary atherosclerosis - pathological aspects
Virmani, R., Kolodgie, F. D., BURKE, A. P., & Farb, A. A. (2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8239-2_2 · Cited by 3
Neutrophil Myeloperoxidase: Effector of Host Defense and Host Damage
Deby-Dupont, G. P., Deby, C. M. T., & Lamy, M. (1998) · Yearbook of intensive care and emergency medicine · doi:10.1007/978-3-642-72038-3_7 · Cited by 3
Vitamin C and Cardiovascular Diseases
Carr, A. C., & Frei, B. B. (2001) · doi:10.1201/9780203904046-14 · Cited by 3
Immunology of Atherosclerosis
Vaarala, O. (2001) · CRC Press eBooks · doi:10.1201/9781420040395.ch5 · Cited by 3
A novel rhodamine-based fluorescent probe for selective detection of ClO– and its application in living cell imaging
Yang, C., Zuo, M., Hu, X., Chen, X., Zhang, D., Qi, Z., Zhao, X., & Zuo, H. (2018) · Canadian Journal of Chemistry · doi:10.1139/cjc-2018-0123 · Cited by 2
Side-chain-fixed homoadamantane-fused tetrahydroquinoxaline coumarin: A robust platform for highly photostable HClO probe development
Liu, Q., Wang, J., Chen, W., Liu, Q., Sheng, J., Zhang, S., & Yang, L. (2025) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2025.137705 · Cited by 2
A Light‐Up Fluorescent Probe for Detection of Reactive Oxygen Species and a Nerve Gas Simulant: Applications in Environmental, Cellular, and Vapor Phases
Banik, D., Maiti, A., Halder, S., Ghosh, P., Banerjee, S., Mandal, D., Jana, K., & Mahapatra, A. K. (2025) · Chemistry - An Asian Journal · doi:10.1002/asia.202500747 · Cited by 2
Nitrite, a Reactive Nitrogen Species, Protects Human Alpha-2-Macroglobulin from Halogenated Oxidant, HOCl
Khan, M. W., Naqshbandi, A., Zubair, H., Ahsan, H., Khan, S. A., & Khan, F. H. (2010) · The Protein Journal · doi:10.1007/s10930-010-9249-1 · Cited by 2
Effects of Hyperoxia and Aging on Hepatocyte, Cholesterol and Triglyceride Levels in Pigeon
Alhazza, I. M., ., M. A.-M., & ., A. S. A. H. (2005) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2005.771.775 · Cited by 2
Is hypochlorous acid (HOCl) involved in age‐related nuclear cataract?
Hazell, L. J., Fu, H., Dean, R. T., Stacker, R., & Truscott, R. J. W. (2002) · Clinical and Experimental Optometry · doi:10.1111/j.1444-0938.2002.tb03015.x · Cited by 2
Self-citation
Antioxidant Defenses in the Vascular Wall
Stocker, R. (2000) · Developments in cardiovascular medicine · doi:10.1007/978-1-4615-4649-8_3 · Cited by 2
Self-citation
Hypochlorous Acid Induces Caspase Dependent Apoptosis in Saccharomyces cerevisiae
Kaluç, N., & Thomas, P. B. (2021) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2021.94004 · Cited by 2
Vitamin C and Cardiovascular Diseases
Frei, B. B., & Carr, A. C. (2001) · CRC Press eBooks · doi:10.1201/9780203904046.ch8 · Cited by 2
Peroxidases: A Historical Overview of Milestones in Research on Myeloperoxidase
Clark, R. A. (2000) · Springer eBooks · doi:10.1007/978-3-642-58314-8_1 · Cited by 2
7,8-Dihydroneopterin-mediated protection of low density lipoprotein, but not human macrophages, from oxidative stress
Firth, C. A. (2006) · UC Research Repository (University of Canterbury) · doi:10.26021/6713 · Cited by 2
Relation of myeloperoxidase promoter polymorphism and long‐term hormone replacement therapy to oxidized low‐density lipoprotein autoantibodies in postmenopausal women
Mäkelä, R., Dastidar, P., Jokela, H., Jaakkola, O., Saarela, M., Punnonen, R., & Lehtimäki, T. J. (2006) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510600727603 · Cited by 2
An improved method for the sensitive monitoring of low density lipoprotein modification by myeloperoxidase
Jerlich, A., Hammel, M., Horáková, Ľ., & Schaur, R. J. (2001) · Redox Report · doi:10.1179/135100001101536319 · Cited by 2
Chronic infections and coronary heart disease
Halliwell, B. B. (1997) · The Lancet · doi:10.1016/s0140-6736(05)64076-7 · Cited by 2
Estudio de la capacidad antioxidante y la biodisponibilidad de los compuestos fenólicos del aceite de oliva. Primeras etapas en el desarrollo de un aceite de oliva funcional
Cantero, A. S. (2009) · TDX (Tesis Doctorals en Xarxa) · Cited by 2
Mechanisms of LDL Oxidation
McCall, M. R., & Frei, B. B. (2000) · Developments in cardiovascular medicine · doi:10.1007/978-1-4615-4649-8_5 · Cited by 2
Effects of Cerastes cerastes gasperettii Venom on Hepatocyte Mitochondria Ultrastructure and Blood Cells Count
Al‐Sadoon, M. K., & ., A. S. A. H. (2005) · Journal of Medical Sciences(Faisalabad) · doi:10.3923/jms.2005.253.259 · Cited by 1
Bioactivities of Betalains
Hussain, E. A., Sadiq, Z., & Zia‐Ul‐Haq, M. (2018) · Springer eBooks · doi:10.1007/978-3-319-95624-4_6 · Cited by 1
Rational Design of ortho-Vinylhydropyridine-Assisted Amino-fluorophore as Hypochlorite Fluorescent Probe
Chen, Z., Hu, Y. W., Ma, L., Zhang, Z., & Liu, C. (2023) · Chinese Journal of Organic Chemistry · doi:10.6023/cjoc202205019 · Cited by 1
Lipoprotein-Associated Oxidative Stress
Le, N. (2016) · CRC Press eBooks · doi:10.1201/b20228-8 · Cited by 1
Degenerated HDL and Its Clinical Implications
Honda, H., Matsunaga, T., & Komoda, T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812513-7.00003-3 · Cited by 1
Binding of Myeloperoxidase to the Extracellular Matrix of Smooth Muscle Cells and Subsequent Matrix Modification
(2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.10.295 · Cited by 1
Mental health access to care in Missouri.
Shoyinka, S. O., & Lauriello, J. (2012) · Europe PMC (PubMed Central) · Cited by 1
The uremic syndrome and pathophysiology of chronic renal failure
Hörl, W. H. (2004) · Springer eBooks · doi:10.1007/978-1-4020-2275-3_3 · Cited by 1
Dietary vitamin e in an atherogenic hamster model
Rein, D., YOKOYAMA, W. H., Xu, R., Walzem, R. L., & German, J. B. (1998) · Nutrition Research · doi:10.1016/s0271-5317(98)00043-8 · Cited by 1
Toxicity of 7-ketocholesterol as a mechanism of oxidised low density lipoprotein-induced cellular death
Rutherford, L. D. (2010) · UC Research Repository (University of Canterbury) · doi:10.26021/9172 · Cited by 1
Nitric Oxide Regulation of Membrane and Lipoprotein Oxidation in the Vasculature
Freeman, B. Α., Eiserich, J. P., & O’Donnell, V. B. (1998) · Springer eBooks · doi:10.1007/978-1-4757-2907-8_6 · Cited by 1
SLE as a Model of Autoimmune Atherosclerosis
Vaarala, O. (2001) · Elsevier eBooks · doi:10.1016/b978-044450669-6/50030-x
Reactive Oxygen and Nitrogen Species and Adult Respiratory Distress Syndrome (ARDS): New Mechanisms to be Considered
van der Vliet, A., Cross, C. E., & Eiserich, J. P. (1998) · Springer eBooks · doi:10.1007/978-1-4419-8634-4_50
New insights in platelet signaling by Low Density Lipoprotein
Relou, I. A. M. (2003) · Utrecht University Repository (Utrecht University)
Experimental studies on innate immune regulatory proteins during non-infectious tissue damage : a focus on Mammose-binding lectin as an innate regulator of immunity
Matthijsen, R. A. (2010) · doi:10.26481/dis.20101112rm
Aspects of endothelial function testing in coronary vascular disease
Monnink, S. H. J. (2003) · University of Groningen research database (University of Groningen / Centre for Information Technology)
Antioxidants and Chronic Vascular Disease: Animal Studies
Cyprus, T., & Praticò, D. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-387-29553-4_9
Use of Gene Transfer to Study HDL Remodeling
Oka, K., & Chan, L. (2007) · Wiley eBooks · doi:10.1002/9783527625178.ch9
Myeloperoxidase and anti-myeloperoxidase autoantibodies in renal inflammation
Huugen, D. (2007) · doi:10.26481/dis.20071005dh
Aminoglycosides as Substrates and Inhibitors of Peroxidases: A Possible Role of These Antibiotics Against Myeloperoxidase-Dependent Cytotoxicity
Lorrai, A., Padiglia, A., Medda, R., Bellelli, A., Arcovito, A., & Floris, G. (2002) · Journal of Protein Chemistry · doi:10.1023/a:1014524227764
This student paper was written as an assignment in the graduate course Free Radicals in Biology and Medicine
Buettner, G. R., Oberley, L. W., Spitz, D. R., & Domann, F. E. (2003)
Role of -463G/A Promoter Polymorphism of Myeloperoxidase in the Development of Atherosclerosis
Mäkelä, R. (2009) · Tampere University Institutional Repository (Tampere University)
Aktivierung von neutrophilen Granulozyten ist ein zeitlicher Vorläufer von myokardialen Zellschäden bei akutem Myokardinfarkt
Klinik, A. D. M. (2010)
Aterosklerotik kardiyovasküler hastalığı olan bireylerin kanlarında toksik metal düzeyleri
Can, F. E. (2009)
Regulation of inflammation-associated S100 proteins in fibroblasts and their expression in atherosclerosis
Af, R. (2022) · UNSWorks (UNSW Sydney) · doi:10.26190/unsworks/21514
Cytotoxicity of Hypochlorite-oxidised Proteins
Burgess, L. M. (2012) · UC Research Repository (University of Canterbury) · doi:10.26021/7726
Effect of a Lifestyle and Type 2 Diabetes-Prevention Intervention on Biomarkers of Oxidative Stress in Obese Prediabetic Latino Youth
Mexia, R., & María, A. (2017)
Myeloperoxidase-derived oxidants: their Intracellular targets, defence mechanisms and role in disease
Nedoboy, P. E. (2014) · UPT. Syiah Kuala University Library (Syiah Kuala University)
3-Nitrotyrosine as an indicator of the disease state intermittent claudication
Dean, S. (2009)
Myeloperoxidase activity predicts atherosclerotic plaque disruption and atherothrombosisPreprint
Nadel, J., Wang, X., Saha, P., Bongers, A., Tumanov, S., Giannotti, N., Chen, W., Vigder, N., Chowdhury, M. M., da Cruz, G. J. L., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.08.561454
Self-citation
Construction of CDs@β-CD@CCM ratiometric fluorescence probe for FRET-based ClO–-sensing
Xu, R., Hu, Z., Dong, X., Xiao, X., & Ding, Y. J. (2024) · Nanotechnology · doi:10.1088/1361-6528/ad6fa8
Immunohistochemistry
Khelfi, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-60738-7_17
The role of glycation and glycoxidation of low-density lipoproteins in foam cell formation.
Brown, B. E. (2004) · The Sydney eScholarship Repository (The University of Sydney)
A Coumarin Derived 2-Methylthio-4-Hydroxypyrimidine[3,4-b]coumarin Fluorescent Chemosensor for Detection of Hypochlorite Ions in Aqueous Medium
Aruna, Kanchan, Agarwala, A., Kumar, G., & Shrivastava, R. (2026) · Journal of Fluorescence · doi:10.1007/s10895-026-04737-0
Effet d'un traitement périnatal avec un hypocholestérolémiant (cholestyramine) et/ou un antioxydant (vitamine E) sur le développement de l'athérosclérose chez la descendance adulte de souris déficientes en apolipoprotéine E
Habib, M. (2022) · theses.fr (ABES) · doi:10.70675/e634ffe7zc86dz4e0fzb03dz223ee5589a93
Proteomic analysis of oxidative modifications in human atherosclerotic plaques and control arteries
Yang-Jensen, K. C., Lorentzen, L. G., Yeung, K., López‐Alarcón, C., Eiberg, J., & Davies, M. J. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104417
Netosis, Myeloperoxidase and Halogenative Stress: Interrelationship and Role in Pathology
Panasenko, O. M., Gorudko, I. V., Grigorieva, D. V., Vakhrusheva, T. V., Sokolov, A. V., & Гусев, С. А. (2026) · Biochemistry (Moscow) · doi:10.1134/s0006297926601619
BindingDB Entry 50006830: The development of myeloperoxidase inhibitors.
BindingDB (2021) · UC San Diego · doi:10.7270/q2bc42s5
Molecular Pathology of Oxidative Damage Induced by the Myeloperoxidase System of Activated Phagocytes
Heinecke, J. W. (1997) · Springer eBooks · doi:10.1007/978-94-017-1607-9_19

Authors: Hazell, L. J., Arnold, L., Flowers, D., Waeg, G., Malle, E., & Stocker, R.
Affiliations: The Heart Research Institute (AU)
The University of Sydney (AU)
University of Graz (AT)
ORCID: Malle, E
Stocker, R
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1996-03-15
Volume: 97
Issue: 6
Pages: 1535-1544
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci118576
PMC: PMC507214
OpenAlex: W2118480498
Cited by: 592
References: 39
Citations by year: 2026: 3 · 2025: 4 · 2024: 14 · 2023: 14 · 2022: 19 · 2021: 12 · 2020: 18 · 2019: 20 · 2018: 26 · 2017: 16 · 2016: 12 · 2015: 17 · 2014: 15 · 2013: 13 · 2012: 16
FWCI: 11.70
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart Foundation of Australia
Austrian Science Fund
Medical Research Council
National Health and Medical Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: hypochlorite, myeloperoxidase, atherosclerosis, LDL oxidation, oxidized LDL, atherosclerotic plaque, macrophages, smooth muscle cells, endothelial cells, oxidizing agents, atherogenesis
MeSH terms: Arteriosclerosis, Humans, Hypochlorous Acid, Immunohistochemistry, Lipoproteins, LDL, Oxidation-Reduction, Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Presence of hypochlorite-modified proteins in human atherosclerotic lesions.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks