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Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection.
Open accessAbstract
Clearance of the hepatitis B virus (HBV) during acute hepatitis is associated with a strong, polyclonal, multispecific cytotoxic T lymphocyte (CTL) response to the viral envelope, nucleocapsid and polymerase proteins that persists for decades after clinical recovery. In contrast, chronically infected patients usually fail to mount a strong CTL response to this virus. In this study we demonstrate that chronically infected patients who experience a spontaneous or interferon-induced remission develop a CTL response to HBV that is similar in strength and specificity to patients who have recovered from acute hepatitis. The results suggest that specific immunotherapeutic enhancement of the CTL response to HBV should be possible in chronically infected patients, and that it could lead to viral clearance in these individuals with resolution of chronic liver disease.
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Citations
Cited by
Genomic analysis of the host response to hepatitis C virus infection
Su, A. I., Pezacki, J. P., Wodicka, L., Brideau, A. D., Supekova, L., Thimme, R., Wieland, S., Bukh, J., Purcell, R. H., Schultz, P. G., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202608199 · Cited by 1,161
Self-citationThimme, R., Wieland, S., Steiger, C., Ghrayeb, J., Reimann, K. A., Purcell, R. H., & Chisari, F. V. (2003) · Journal of Virology · doi:10.1128/jvi.77.1.68-76.2003 · Cited by 979
Self-citationRehermann, B., Ferrari, C., Pasquinelli, C., & Chisari, F. V. (1996) · Nature Medicine · doi:10.1038/nm1096-1104 · Cited by 854
Self-citationBréchot, C., Thiers, V., Kremsdorf, D., Nalpas, B., Pol, S., & Paterlini-Bréchot, P. (2001) · Hepatology · doi:10.1053/jhep.2001.25172 · Cited by 560
He, X.-S., Rehermann, B., López-Labrador, F. X., Boisvert, J., Cheung, R., Mumm, J., Wedemeyer, H., Berenguer, M., Wright, T. L., Davis, M. M., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5692 · Cited by 417
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Metadata
- Authors
- Rehermann, B., Lau, D., Hoofnagle, J. H., & Chisari, F. V.
- Venue
- Journal of Clinical Investigation
- Published
- 1996-04-01
- Volume
- 97
- Issue
- 7
- Pages
- 1655-1665
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1985262993
- Cited by
- 294
- References
- 0
- FWCI
- 13.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rehermann, B., Lau, D., Hoofnagle, J. H., & Chisari, F. V. (1996). Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection. Journal of Clinical Investigation. https://doi.org/10.1172/jci118592
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
