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Cited by 979Hepatitis B Virus StudiesHepatitis C virus researchHIV Research and Treatment

CD8 + T Cells Mediate Viral Clearance and Disease Pathogenesis during Acute Hepatitis B Virus Infection

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Thimme, Robert, Wieland, Stefan, Steiger, Carola, Ghrayeb, John, Reimann, Keith A., Purcell, Robert H., Chisari, Francis V.·2003·Journal of Virology
DOI 10.1128/jvi.77.1.68-76.2003PMC PMC140637
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Abstract

Although the CD4 + - and CD8 + -T-cell responses to the hepatitis B virus (HBV) are thought to be crucial for the control of HBV infection, the relative contribution of each T-cell subset as an effector of viral clearance is not known. To examine this question, we monitored the course of HBV infection in control, CD4-depleted, and CD8-depleted chimpanzees. Our results demonstrate that CD8 + cells are the main effector cells responsible for viral clearance and disease pathogenesis during acute HBV infection, and they suggest that viral clearance is mediated by both noncytolytic and cytolytic effector functions of the CD8 + -T-cell response.

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  • A central role for CD8+ CTLs in virus elimination in the liver is supported by experimental depletion studies in which depletion of CD8+ T cells delays clearance of hepatotropic viruses in chimpanzees.

    “A central role for CD8+ CTLs in virus elimination in the liver is further supported by experimental depletion studies, where depletion of CD8+ T cells delays the clearance of hepatotropic viruses in chimpanzees(131, 185).”

    From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [131]

  • These cytokines can inhibit HBV replication without causing cell damage.

    “These cytokines can inhibit HBV replication without causing cell damage(130-132).”

    From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [131]

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Authors
Thimme, R., Wieland, S., Steiger, C., Ghrayeb, J., Reimann, K. A., Purcell, R. H., & Chisari, F. V.
Affiliations
  • Scripps Research Institute (US)
  • Centocor, Malvern, Pennsylvania
  • Beth Israel Deaconess Medical Center (US)
  • National Institutes of Health (US)
Corresponding author
Chisari, Francis V.
ORCID
Venue
Journal of Virology
Publisher
American Society for Microbiology
Published
2003-01
Volume
77
Issue
1
Pages
68-76
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
DOI
10.1128/jvi.77.1.68-76.2003
PMC
PMC140637
OpenAlex
W2098459535
Cited by
979
References
0
Citations by year
2026: 31 · 2025: 40 · 2024: 37 · 2023: 50 · 2022: 47 · 2021: 59 · 2020: 43 · 2019: 52 · 2018: 52 · 2017: 57 · 2016: 47 · 2015: 55 · 2014: 58 · 2013: 49 · 2012: 32
FWCI
16.75
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Journal of Virology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
Funders
  • Cancer Research Institute
  • Deutsche Forschungsgemeinschaft
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (R01AI020001)
  • National Center for Research Resources (R24RR016001)
Topics
  • Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords
hepatitis B virus, acute hepatitis B, CD8+ T cells, CD4+ T cells, viral clearance, pathogenesis, chimpanzees, CD4 depletion, CD8 depletion, antiviral immunity
MeSH terms
Acute Disease, Animals, Pan troglodytes, Hepatitis B, Interferon-gamma, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Viral Load

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