The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response.
Open accessAbstract
The anti-viral T cell response is believed to play a central role in the pathogenesis of hepatitis C virus infection. Since chronic evolution occurs in > 50% of HCV infections, the sequential analysis of the T cell response from the early clinical stages of disease may contribute to define the features of the T cell response associated with recovery or chronic viral persistence. For this purpose, 21 subjects with acute hepatitis C virus infection were sequentially followed for an average time of 44 wk. Twelve patients normalized transaminase values that remained normal throughout the follow-up period; all but two cleared hepatitis C virus-RNA from serum. The remaining nine patients showed persistent viremia and elevated transaminases. Analysis of the peripheral blood T cell proliferative response to core, E1, E2, NS3, NS4, and NS5 recombinant antigens and synthetic peptides showed that responses to all hepatitis C virus antigens, except E1, were significantly more vigorous and more frequently detectable in patients who normalized transaminase levels than in those who did not. By sequential evaluation of the T cell response, a difference between the two groups of patients was already detectable at the very early stages of acute infection and then maintained throughout the follow-up period. The results suggest that the vigor of the T cell response during the early stages of infection may be a critical determinant of disease resolution and control of infection.
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Cites
Lymphocyte responses and cytokines
Paul, W. E., & Seder, R. A. (1994) · Cell · doi:10.1016/0092-8674(94)90332-8 · Cited by 1,828
Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen
Lehmann, P. V., Forsthuber, T., Miller, A., & Sercarz, E. E. (1992) · Nature · doi:10.1038/358155a0 · Cited by 1,186
Diepolder, H. M., Zachoval, R., Hoffmann, R. M., Jung, M.-C., Pape, G. R., Wierenga, E. A., Santantonio, T., & Eichenlaub, D. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91691-1 · Cited by 687
Typing of hepatitis C virus isolates and characterization of new subtypes using a line probe assay
Stuyver, L., Rossau, R., Wyseur, A., Duhamel, M., Vanderborght, B., Van Heuverswyn, H., & Maertens, G. (1993) · Journal of General Virology · doi:10.1099/0022-1317-74-6-1093 · Cited by 685
Koziel, M. J., Dudley, D., Wong, J. T., Dienstag, J., Houghton, M., Ralston, R., & Walker, B. D. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.10.3339 · Cited by 459
Self-citationRoles Of Alpha-Beta And Gamma-Delta T-Cell Subsets In Viral Immunity
Doherty, P. (1992) · Annual Review of Immunology · doi:10.1146/annurev.immunol.10.1.123 · Cited by 354
Cerny, A., McHutchison, J. G., Pasquinelli, C., Brown, M. E., Brothers, M. A., Grabscheid, B., Fowler, P., Houghton, M., & Chisari, F. V. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117694 · Cited by 321
Self-citationT-lymphocyte response to hepatitis C virus in different clinical courses of infection
Botarelli, P., Brunetto, M. R., Minutello, M. A., Calvo, P., Unutmaz, D., Weiner, A. J., Choo, Q.-L., Shuster, J. R., Kuo, G., Bonino, F., et al. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90430-k · Cited by 313
Self-citationKoziel, M. J., Dudley, D., Afdhal, N., Choo, Q. L., Houghton, M., Ralston, R., & Walker, B. D. (1993) · Journal of Virology · doi:10.1128/jvi.67.12.7522-7532.1993 · Cited by 287
Self-citationTo C or not to C: these are the questions
Alter, H. (1995) · Blood · doi:10.1182/blood.v85.7.1681.bloodjournal8571681 · Cited by 280
Cited by
Micallef, J. M., Kaldor, J. M., & Dore, G. J. (2006) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2005.00651.x · Cited by 871
Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism
Sette, A., & Sidney, J. (1999) · Immunogenetics · doi:10.1007/s002510050594 · Cited by 635
Bowen, D. G., Zen, M., Holz, L., Davis, T., McCaughan, G. W., & Bertolino, P. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21593 · Cited by 316
Day, C. L., Seth, N. P., Lucas, M., Appel, H., Gauthier, L., Lauer, G. M., Robbins, G. K., Szczepiorkowski, Z. M., Casson, D. R., Chung, R. T., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18509 · Cited by 294
Orland, J. R., Wright, T. L., & Cooper, S. (2001) · Hepatology · doi:10.1053/jhep.2001.22112 · Cited by 196
Metadata
- Authors
- Missale, G., Bertoni, R., Lamonaca, V, Valli, A., Massari, M., Mori, C., Rumi, M. G., Houghton, M., Fiaccadori, F., & Ferrari, C.
- Venue
- Journal of Clinical Investigation
- Published
- 1996-08-01
- Volume
- 98
- Issue
- 3
- Pages
- 706-714
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2084446925
- Cited by
- 658
- References
- 16
- FWCI
- 15.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Missale, G., Bertoni, R., Lamonaca, V, Valli, A., Massari, M., Mori, C., Rumi, M. G., Houghton, M., Fiaccadori, F., & Ferrari, C. (1996). Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. Journal of Clinical Investigation. https://doi.org/10.1172/jci118842
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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