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Cited by 184Cardiac electrophysiology and arrhythmiasCardiomyopathy and Myosin StudiesCardiovascular Function and Risk Factors

Diminished post-rest potentiation of contractile force in human dilated cardiomyopathy. Functional evidence for alterations in intracellular Ca2+ handling

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Pieske, B, Sütterlin, M, Schmidt-Schweda, S, Minami, K, Meyer, M, Olschewski, M, Holubarsch, C, Just, H +1 more·1996·Journal of Clinical Investigation
DOI 10.1172/jci118849PMC PMC507487
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Abstract

Post-rest contractile behavior of isolated myocardium indicates the capacity of the sarcoplasmic reticulum (SR) to store and release Ca2+. We investigated post-rest behavior in isolated muscle strips from nonfailing (NF) and endstage failing (dilated cardiomyopathy [DCM]) human hearts. At a basal stimulation frequency of 1 Hz, contractile parameters of the first twitch after increasing rest intervals (2-240 s) were evaluated. In NF (n = 9), steady state twitch tension was 13.7 +/- 1.8 mN/mm2. With increasing rest intervals, post-rest twitch tension continuously increased to maximally 29.9 +/- 4.1 mN/mm2 after 120s (P < 0.05) and to 26.7 +/- 4.5 mN after 240 s rest. In DCM (n = 22), basal twitch tension was 10.0 +/- 1.5 mN/mm2 and increased to maximally 13.6 +/- 2.2 mN/mm2 after 20 s rest (P < 0.05). With longer rest intervals, however, post-rest twitch tension continuously declined (rest decay) to 4.7 +/- 1.0 mN/mm2 at 240 s (P < 0.05). The rest-dependent changes in twitch tension were associated with parallel changes in intracellular Ca2- transients in NF and DCM (aequorin method). The relation between rest-induced changes in twitch tension and aequorin light emission was similar in NF and DCM, indicating preserved Ca(2-)-responsiveness of the myofilaments. Ryanodine (1 microM) completely abolished post-rest potentiation. Increasing basal stimulation frequency (2 Hz) augmented post-rest potentiation, but did not prevent rest decay after longer rest intervals in DCM. The altered post-rest behavior in failing human myocardium indicates disturbed intracellular Ca2- handling involving altered function of the SR.

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  • Increasing stimulation frequency in rabbit in vitro preparations from 1 to 4 Hz and human preparations from 0.5 to 2.5 Hz increases contractile force by about 120-200% and 81-168%, respectively.

    “Increasing the stimulation frequency in rabbit (from 1 Hz to 4 Hz) and human in vitro muscle preparations (from 0.5 Hz to 2.5 Hz) results increase in contractile force of about 120–200% and 81–168%, respectively”

    From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Pieske, et al., 1996

  • Both rabbit and human ventricles show robust positive force-frequency responses.

    “Both rabbit and human ventricles exhibit robust positive force-frequency responses.”

    From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Pieske, et al., 1996

  • The force of isolated human cardiac trabeculae increases ~81-168% as stimulation frequency is increased from 0.5 Hz to 2.5 Hz.

    “the force of isolated human cardiac trabeculae increases ~81–168% as the stimulation frequency is increased from 0.5 Hz to 2.5 Hz (Chaudhary, et al., 2004; Pieske, et al., 1996; Rossman, et al., 2004).”

    From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Pieske, et al., 1996

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Authors
Pieske, B., Sütterlin, M., Schmidt-Schweda, S., Minami, K., Meyer, M., Olschewski, M., Holubarsch, C., Just, H., & Hasenfuss, G.
Affiliations
  • University of Freiburg (DE)
  • Heart and Diabetes Center North Rhine-Westphalia (DE)
ORCID
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1996-08-01
Volume
98
Issue
3
Pages
764-776
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci118849
PMC
PMC507487
OpenAlex
W2036663915
Cited by
184
References
70
Citations by year
2026: 2 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 11 · 2016: 2 · 2015: 7 · 2014: 2 · 2013: 3 · 2012: 5
FWCI
6.38
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
  • GRO (submittedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
dilated cardiomyopathy, post-rest potentiation, intracellular calcium homeostasis, sarcoplasmic reticulum, calcium transients, cardiac contractility, aequorin, ryanodine, myofilament calcium responsiveness, heart failure
MeSH terms
Adult, Aged, Calcium, Cardiomyopathy, Dilated, Female, Humans, Male, Middle Aged, Myocardial Contraction, Ryanodine, Sarcoplasmic Reticulum, Stroke Volume

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