The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance.
Open accessAbstract
The hexosamine biosynthetic pathway has been hypothesized to be involved in mediating some of the toxic effects of hyperglycemia. Glutamine:fructose-6-phosphate amidotransferase (GFA), the first and rate limiting enzyme of the hexosamine biosynthetic pathway, was overexpressed in skeletal muscle and adipose tissue of transgenic mice. A 2.4-fold increase of GFA activity in muscle of the transgenic mice led to weight-dependent hyperinsulinemia in random-fed mice. The hyperinsulinemic-euglycemic clamp technique confirmed that transgenic mice develop insulin resistance, with a glucose disposal rate of 68.5 +/- 3.5 compared with 129.4 +/- 9.4 mg/kg per min (P < 0.001) for littermate controls. The decrease in the glucose disposal rate of the transgenic mice is accompanied by decreased protein but not mRNA levels of the insulin-stimulated glucose transporter (GLUT4). These data support the hypothesis that excessive flux through the hexosamine biosynthesis pathway mediates adverse regulatory and metabolic effects of hyperglycemia, specifically insulin resistance of glucose disposal. These mice can serve as a model system to study the mechanism for the regulation of glucose homeostasis by hexosamines.
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Cites
Characterization of Insulin Resistance and NIDDM in Transgenic Mice With Reduced Brown Fat
Hamann, A., Benecke, H., Marchand-Brustel, Y. L., Susulic, V. S., Lowell, B. B., & Flier, J. S. (1995) · Diabetes · doi:10.2337/diab.44.11.1266 · Cited by 89
Cited by
Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232
Hart, G. W., Slawson, C., Ramirez-Correa, G., & Lagerlof, O. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060608-102511 · Cited by 1,317
Glucose Transporters and Insulin Action — Implications for Insulin Resistance and Diabetes Mellitus
Shepherd, P. R., & Kahn, B. B. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410406 · Cited by 1,295
Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
Virkamäki, A., Ueki, K., & Kahn, C. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6609 · Cited by 854
A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
Wang, J., Liu, R., Hawkins, M., Barzilai, N., & Rossetti, L. (1998) · Nature · doi:10.1038/31474 · Cited by 836
Metadata
- Authors
- Hebert, L. F., Daniels, M. C., Zhou, J., Crook, E. D., Turner, R. L., Simmons, S. T., Neidigh, J. L., Zhu, J. S., Baron, A. D., & McClain, D. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1996-08-15
- Volume
- 98
- Issue
- 4
- Pages
- 930-936
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2087910122
- Cited by
- 335
- References
- 1
- FWCI
- 8.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hebert, L. F., Daniels, M. C., Zhou, J., Crook, E. D., Turner, R. L., Simmons, S. T., Neidigh, J. L., Zhu, J. S., Baron, A. D., & McClain, D. A. (1996). Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance. Journal of Clinical Investigation. https://doi.org/10.1172/jci118876
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