The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Obstructive sleep apnea as a cause of systemic hypertension. Evidence from a canine model.
Open accessAbstract
Several epidemiological studies have identified obstructive sleep apnea (OSA) as a risk factor for systemic hypertension, but a direct etiologic link between the two disorders has not been established definitively. Furthermore, the specific physiological mechanisms underlying the association between OSA and systemic hypertension have not been identified. The purpose of this study was to systematically examine the effects of OSA on daytime and nighttime blood pressure (BP). We induced OSA in four dogs by intermittent airway occlusion during nocturnal sleep. Daytime and nighttime BP were measured before, during, and after a 1-3-mo long period of OSA. OSA resulted in acute transient increases in nighttime BP to a maximum of 13.0+/-2.0 mmHg (mean+/-SEM), and eventually produced sustained daytime hypertension to a maximum of 15.7+/-4.3 mmHg. In a subsequent protocol, recurrent arousal from sleep without airway occlusion did not result in daytime hypertension. The demonstration that OSA can lead to the development of sustained hypertension has considerable importance, given the high prevalence of both disorders in the population.
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Cites
The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults
Young, T., Palta, M., Dempsey, J., Skatrud, J., Weber, S., & Badr, S. (1993) · New England Journal of Medicine · doi:10.1056/nejm199304293281704 · Cited by 10,183
The Triad of Sleep Apnea, Hypertension, and Chronic Kidney Disease: A Spectrum of Common Pathology
Aziz, F., & Chaudhary, K. (2017) · Cardiorenal Medicine · doi:10.1159/000450796 · Cited by 3,267
Mortality and Apnea Index in Obstructive Sleep Apnea
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Sleep Apnea and Hypertension: A Population-based Study
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Repetitive, episodic hypoxia causes diurnal elevation of blood pressure in rats.
Fletcher, E. C., Lesske, J., Qian, W., Miller, C. C., & Unger, T. (1992) · Hypertension · doi:10.1161/01.hyp.19.6.555 · Cited by 503
Snoring as a risk factor for ischaemic heart disease and stroke in men.
Koskenvuo, M., Kaprio, J., Telakivi, T., Partinen, M., Heikkila, K., & Sarna, S. (1987) · BMJ · doi:10.1136/bmj.294.6563.16 · Cited by 483
Sleep Apnea -- A Major Public Health Problem
Phillipson, E. A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199304293281712 · Cited by 410
Self-citationSLEEP APNOEA IN A HYPERTENSIVE POPULATION
Kales, A., Cadieux, R., Shaw, L., Vela-Bueno, A., Bixler, E., Schneck, D., Locke, T., & Soldatos, C. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91107-3 · Cited by 382
Snoring and sleep apnoea in men: association with central obesity and hypertension.
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Arterial blood pressure responses to graded transient arousal from sleep in normal humans
Davies, R. J., Belt, P. J., Roberts, S. J., Ali, N. J., & Stradling, J. R. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.74.3.1123 · Cited by 314
Cited by
Marin, J. M., Carrizo, S. J., Vicente, E., & Agusti, A. G. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71141-7 · Cited by 4,678
The Triad of Sleep Apnea, Hypertension, and Chronic Kidney Disease: A Spectrum of Common Pathology
Aziz, F., & Chaudhary, K. (2017) · Cardiorenal Medicine · doi:10.1159/000450796 · Cited by 3,267
Pathophysiology of Sleep Apnea
Dempsey, J. A., Veasey, S. C., Morgan, B. J., & O'Donnell, C. P. (2010) · Physiological Reviews · doi:10.1152/physrev.00043.2008 · Cited by 2,243
Adult obstructive sleep apnoea
Jordan, A. S., McSharry, D. G., & Malhotra, A. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60734-5 · Cited by 1,735
Goldberger, J. J., Cain, M. E., Hohnloser, S. H., Kadish, A. H., Knight, B. P., Lauer, M. S., Maron, B. J., Page, R. L., Passman, R. S., Siscovick, D., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189375 · Cited by 1,450
Metadata
- Authors
- Brooks, D., Horner, R. L., Kozar, L. F., Render-Teixeira, C. L., & Phillipson, E. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1997-01-01
- Volume
- 99
- Issue
- 1
- Pages
- 106-109
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2018281450
- Cited by
- 708
- References
- 23
- FWCI
- 14.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Brooks, D., Horner, R. L., Kozar, L. F., Render-Teixeira, C. L., & Phillipson, E. A. (1997). Obstructive sleep apnea as a cause of systemic hypertension. Evidence from a canine model. Journal of Clinical Investigation. https://doi.org/10.1172/jci119120
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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