The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Hyperexpression of mitogen-activated protein kinase in human breast cancer.
Open accessAbstract
Mitogen-activated protein (MAP) kinases act as transducers of extracellular signaling via tyrosine kinase-growth factor receptors and G-protein-linked receptors to elements regulating transcription. The activity, abundance, and localization of MAP kinase was investigated in normal and malignant neoplasia of the breast. In carcinoma of the breast, MAP kinase was heavily phosphorylated on tyrosyl residues and its activity elevated 5-10-fold over benign conditions, such as fibroadenoma and fibrocystic disease. By in situ reverse transcription-polymerase chain reaction, hyperexpression of MAP kinase mRNA can be localized to malignant, epithelial cells. Metastatic cells within involved lymph nodes of patients with breast cancer also display hyperexpression of MAP kinase. In spite of persistent activation via phosphorylation, MAP kinase expression is upregulated 5-20-fold and this hyperexpression may be a critical element to initiation as well as the metastatic potential of various forms of human breast cancer.
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Cobb, M. H., & Goldsmith, E. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.25.14843 · Cited by 1,719
Wingo, P. A., Tong, T., & Bolden, S. (1995) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.45.1.8 · Cited by 1,410
Signal transduction via the MAP kinases: proceed at your own RSK.
Blenis, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.5889 · Cited by 1,243
Langdale, J. A. (1994) · The Maize Handbook · doi:10.1007/978-1-4612-2694-9_18 · Cited by 866
Brunet, A., Pagès, G., & Pouysségur, J. (1994) · PubMed · Cited by 219
MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts.
Gupta, S. K., Gallego, C., Johnson, G. L., & Heasley, L. E. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42397-6 · Cited by 219
Arteaga, C. L., Johnson, M. D., Todderud, G., Coffey, R. J., Carpenter, G., & Page, D. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10435 · Cited by 205
Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2.
Janes, P. W., Daly, R. J., DeFazio, A., & Sutherland, R. L. (1994) · PubMed · Cited by 199
Nuovo, G. J., Forde, A., MacConnell, P., & Fahrenwald, R. (1993) · PubMed Central · Cited by 145
Self-citationAgonist Regulation of Gene Expression of Adrenergic Receptors and G Proteins
Hadcock, J. R., & Malbon, C. C. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb05816.x · Cited by 126
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Cited by
Terminal Differentiation of Human Breast Cancer through PPARγ
Mueller, E., Sarraf, P., Tontonoz, P., Evans, R. M., Martin, K. J., Zhang, M., Fletcher, C., Singer, S., & Spiegelman, B. M. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80047-7 · Cited by 851
Wang, F., Weaver, V. M., Petersen, O. W., Larabell, C. A., Dedhar, S., Briand, P., Lupu, R., & Bissell, M. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14821 · Cited by 653
Thrombin receptor overexpression in malignant and physiological invasion processes
Even-Ram, S., Uziely, B., Cohen, P., Grisaru-Granovsky, S., Maoz, M., Ginzburg, Y., Reich, R., Vlodavsky, I., & Bar-Shavit, R. (1998) · Nature Medicine · doi:10.1038/nm0898-909 · Cited by 417
Schnelzer, A., Prechtel, D., Knaus, U., Dehne, K., Gerhard, M., Graeff, H., Harbeck, N., Schmitt, M., & Lengyel, E. (2000) · Oncogene · doi:10.1038/sj.onc.1203621 · Cited by 347
Ito, Y., Sasaki, Y., Horimoto, M., Wada, S., Tanaka, Y., Kasahara, A., Ueki, T., Hirano, T., Yamamoto, H., Fujimoto, J., et al. (1998) · Hepatology · doi:10.1002/hep.510270409 · Cited by 334
Metadata
- Authors
- Sivaraman, V. S., Wang, H., Nuovo, G. J., & Malbon, C. C.
- Venue
- Journal of Clinical Investigation
- Published
- 1997-04-01
- Volume
- 99
- Issue
- 7
- Pages
- 1478-1483
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2052016477
- Cited by
- 451
- References
- 13
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sivaraman, V. S., Wang, H., Nuovo, G. J., & Malbon, C. C. (1997). Hyperexpression of mitogen-activated protein kinase in human breast cancer. Journal of Clinical Investigation. https://doi.org/10.1172/jci119309
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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