The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
TGF-β is a critical mediator of acute lung injury
Open accessAbstract
We have shown that the integrin alphavbeta6 activates latent TGF-beta in the lungs and skin. We show here that mice lacking this integrin are completely protected from pulmonary edema in a model of bleomycin-induced acute lung injury (ALI). Pharmacologic inhibition of TGF-beta also protected wild-type mice from pulmonary edema induced by bleomycin or Escherichia coli endotoxin. TGF-beta directly increased alveolar epithelial permeability in vitro by a mechanism that involved depletion of intracellular glutathione. These data suggest that integrin-mediated local activation of TGF-beta is critical to the development of pulmonary edema in ALI and that blocking TGF-beta or its activation could be effective treatments for this currently untreatable disorder.
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Citations
Cites
The Acute Respiratory Distress Syndrome
Ware, L. B., & Matthay, M. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421806 · Cited by 4,666
Self-citationAbe, M., Harpel, J. G., Metz, C. N., Nunes, I., Loskutoff, D. J., & Rifkin, D. B. (1994) · Analytical Biochemistry · doi:10.1006/abio.1994.1042 · Cited by 757
Cited by
The acute respiratory distress syndrome
Matthay, M. A., Ware, L. B., & Zimmerman, G. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60331 · Cited by 1,706
Self-citationPulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy
George, P. M., Wells, A. U., & Jenkins, R. G. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30225-3 · Cited by 1,085
TGF-β1 Signaling and Tissue Fibrosis
Kim, K. K., Sheppard, D., & Chapman, H. A. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022293 · Cited by 800
Self-citationD’Alessio, F. R., Tsushima, K., Aggarwal, N. R., West, E. E., Willett, M. H., Britos, M. F., Pipeling, M. R., Brower, R. G., Tuder, R. M., McDyer, J. F., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36498 · Cited by 564
Cross Talk among TGF- Signaling Pathways, Integrins, and the Extracellular Matrix
Munger, J. S., & Sheppard, D. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005017 · Cited by 372
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Metadata
- Authors
- Pittet, J.-F., Griffiths, M. J. D., Geiser, T., Kaminski, N., Dalton, S. L., Huang, X., Brown, L. A. S., Gotwals, P. J., Koteliansky, V. E., Matthay, M. A., & Sheppard, D.
- Venue
- Journal of Clinical Investigation
- Published
- 2001-06-15
- Volume
- 107
- Issue
- 12
- Pages
- 1537-1544
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2136761840
- Cited by
- 487
- References
- 2
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: TGF-β is a critical mediator of acute lung injury. https://app.cochat.ai/papers/10.1172/jci11963
- The paper
- Pittet, J.-F., Griffiths, M. J. D., Geiser, T., Kaminski, N., Dalton, S. L., Huang, X., Brown, L. A. S., Gotwals, P. J., Koteliansky, V. E., Matthay, M. A., & Sheppard, D. (2001). TGF-β is a critical mediator of acute lung injury. Journal of Clinical Investigation. https://doi.org/10.1172/jci11963
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
