The DOI matches its Crossref record; 182 of the 182 references it cites were found in a registry or an index.
Regulatory T cells in embryo implantation and the immune response to pregnancy
Open accessAbstract
At implantation, the embryo expresses paternally derived alloantigens and evokes inflammation that can threaten reproductive success. To ensure a robust placenta and sustainable pregnancy, an active state of maternal immune tolerance mediated by CD4+ regulatory T cells (Tregs) is essential. Tregs operate to inhibit effector immunity, contain inflammation, and support maternal vascular adaptations, thereby facilitating trophoblast invasion and placental access to the maternal blood supply. Insufficient Treg numbers or inadequate functional competence are implicated in idiopathic infertility and recurrent miscarriage as well as later-onset pregnancy complications stemming from placental insufficiency, including preeclampsia and fetal growth restriction. In this Review, we summarize the mechanisms acting in the conception environment to drive the Treg response and discuss prospects for targeting the T cell compartment to alleviate immune-based reproductive disorders.
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Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia
Staff, A. C., Fjeldstad, H. E., Fosheim, I. K., Moe, K., Turowski, G., Johnsen, G. M., Alnaes-Katjavivi, P., & Sugulle, M. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.09.026 · Cited by 354
The CD83 molecule - an important immune checkpoint
Grosche, L., Knippertz, I., König, C., Royzman, D., Wild, A. B., Zinser, E., Sticht, H., Muller, Y. A., Steinkasserer, A., & Lechmann, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00721 · Cited by 138
Metadata
- Authors
- Robertson, S. A., Care, A. S., & Moldenhauer, L. M.
- Venue
- Journal of Clinical Investigation
- Published
- 2018-10-01
- Volume
- 128
- Issue
- 10
- Pages
- 4224-4235
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- OpenAlex
- W2892743459
- Cited by
- 462
- References
- 182
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
