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Cited by 336

The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.

β Cell dysfunction during progression of metabolic syndrome to type 2 diabetes

Open access
Hudish, Laura I., Reusch, Jane E.B., Sussel, Lori·2019·Journal of Clinical Investigation
DOI 10.1172/jci129188
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Abstract

In a society where physical activity is limited and food supply is abundant, metabolic diseases are becoming a serious epidemic. Metabolic syndrome (MetS) represents a cluster of metabolically related symptoms such as obesity, hypertension, dyslipidemia, and carbohydrate intolerance, and significantly increases type 2 diabetes mellitus risk. Insulin resistance and hyperinsulinemia are consistent characteristics of MetS, but which of these features is the initiating insult is still widely debated. Regardless, both of these conditions trigger adverse responses from the pancreatic β cell, which is responsible for producing, storing, and releasing insulin to maintain glucose homeostasis. The observation that the degree of β cell dysfunction correlates with the severity of MetS highlights the need to better understand β cell dysfunction in the development of MetS. This Review focuses on the current understanding from rodent and human studies of the progression of β cell responses during the development of MetS, as well as recent findings addressing the complexity of β cell identity and heterogeneity within the islet during disease progression. The differential responses observed in β cells together with the heterogeneity in disease phenotypes within the patient population emphasize the need to better understand the mechanisms behind β cell adaptation, identity, and dysfunction in MetS.

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Metadata

Authors
Hudish, L. I., Reusch, J. E. B., & Sussel, L.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2019-08-19
Volume
129
Issue
10
Pages
4001-4008
ISSN
  • 0021-9738 (ISSN-L)
  • 1558-8238
DOI
10.1172/jci129188
OpenAlex
W2968775432
Cited by
336
References
78
FWCI
28.52
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: β Cell dysfunction during progression of metabolic syndrome to type 2 diabetes. https://app.cochat.ai/papers/10.1172/jci129188
The paper
Hudish, L. I., Reusch, J. E. B., & Sussel, L. (2019). β Cell dysfunction during progression of metabolic syndrome to type 2 diabetes. Journal of Clinical Investigation. https://doi.org/10.1172/jci129188

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.