The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer
Open accessAbstract
Patients with bladder cancer (BCa) with clinical lymph node (LN) metastasis have an extremely poor prognosis. VEGF-C has been demonstrated to play vital roles in LN metastasis in BCa. However, approximately 20% of BCa with LN metastasis exhibits low VEGF-C expression, suggesting a VEGF-C-independent mechanism for LN metastasis of BCa. Herein, we demonstrate that BCa cell-secreted exosome-mediated lymphangiogenesis promoted LN metastasis in BCa in a VEGF-C-independent manner. We identified an exosomal long noncoding RNA (lncRNA), termed lymph node metastasis-associated transcript 2 (LNMAT2), that stimulated human lymphatic endothelial cell (HLEC) tube formation and migration in vitro and enhanced tumor lymphangiogenesis and LN metastasis in vivo. Mechanistically, LNMAT2 was loaded to BCa cell-secreted exosomes by directly interacting with heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1). Subsequently, exosomal LNMAT2 was internalized by HLECs and epigenetically upregulated prospero homeobox 1 (PROX1) expression by recruitment of hnRNPA2B1 and increasing the H3K4 trimethylation level in the PROX1 promoter, ultimately resulting in lymphangiogenesis and lymphatic metastasis. Therefore, our findings highlight a VEGF-C-independent mechanism of exosomal lncRNA-mediated LN metastasis and identify LNMAT2 as a therapeutic target for LN metastasis in BCa.
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Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
Villarroya-Beltri, C., Gutiérrez-Vázquez, C., Sánchez-Cabo, F., Pérez-Hernández, D., Vázquez, J., Martin-Cofreces, N., Martinez-Herrera, D. J., Pascual-Montano, A., Mittelbrunn, M., & Sánchez-Madrid, F. (2013) · Nature Communications · doi:10.1038/ncomms3980 · Cited by 1,971
Extracellular vesicles in cancer — implications for future improvements in cancer care
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Lymphangiogenesis in development and human disease
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Self-citationFang, T., Lv, H., Lv, G., Li, T., Wang, C., Han, Q., Yu, L., Su, B., Guo, L., Huang, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02583-0 · Cited by 995
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Self-citationAn essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
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Cited by
Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer
Han, Q.-F., Li, W.-J., Hu, K.-S., Gao, J., Zhai, W.-L., Yang, J.-H., & Zhang, S.-J. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01671-0 · Cited by 678
Regulation of cargo selection in exosome biogenesis and its biomedical applications in cancer
Lee, Y. J., Shin, K. J., & Chae, Y. C. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01209-y · Cited by 427
Quantitative Proteomics Identifies Proteins Enriched in Large and Small Extracellular Vesicles
Lischnig, A., Bergqvist, M., Ochiya, T., & Lässer, C. (2022) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2022.100273 · Cited by 189
Desjardins, P., Berthiaume, R., Couture, C., Le-Bel, G., Roy, V., Gros-Louis, F., Moulin, V. J., Proulx, S., Chemtob, S., Germain, L., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012201 · Cited by 39
“Exosomes Modify the Gene Expression Pattern in a Cell-Specific Manner We next exposed near confluent hCECs (Figure 6), hCFs (Supplementary Figure S3) and hCEnCs (Supplementary Figure S6) to exosomes isolated from all three cell-types and conducted gene profiling analyses on microarrays using total RNAs isolated from b…”
Background
Metadata
- Authors
- Chen, C., Luo, Y., He, W., Zhao, Y., Kong, Y., Liu, H., Zhong, G., Li, Y., Li, J., Huang, J., Chen, R., & Lin, T.
- Venue
- Journal of Clinical Investigation
- Published
- 2019-12-03
- Volume
- 130
- Issue
- 1
- Pages
- 404-421
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- OpenAlex
- W2979859373
- Cited by
- 389
- References
- 42
- FWCI
- 15.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chen, C., Luo, Y., He, W., Zhao, Y., Kong, Y., Liu, H., Zhong, G., Li, Y., Li, J., Huang, J., Chen, R., & Lin, T. (2019). Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer. Journal of Clinical Investigation. https://doi.org/10.1172/jci130892
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