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Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
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Known miRNA secretion motifs GGAG and AGG are not present in the miRNA sequences of hsa-mir-548 family members present in FF.
“Known miRNA secretion motifs GGAG [34] and AGG [35] are not present in the miRNA sequences of hsa-mir-548 family members present in FF.”
From Hsa-mir-548 family expression in human reproductive tissues (2021) · cites this paper as [34]
For miRNAs, both a non-selective secretion model and preferential or selective mechanisms of sorting into sEVs have been reported.
“For miRNAs, both a non-selective secretion model [13] and preferential or selective mechanisms of sorting into sEVs have been reported [14–16].”
From Differential RNA packaging into small extracellular vesicles by neurons and astrocytes (2021) · cites this paper as [16]
Sumoylated hnRNPA2B1 can specifically bind to a short GGAG sequence on miRNAs called an EXOmotif and transfer these miRNAs into exosomes.
“Sumoylated heterogeneous nuclear ribonucleoprotein (hnRNPA2B1) can specifically bind to a short GGAG sequence on miRNAs called an EXOmotif and transfer these miRNAs into exosomes [16].”
From Differential RNA packaging into small extracellular vesicles by neurons and astrocytes (2021) · cites this paper as [16]
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Metadata
- Authors
- Villarroya-Beltri, C., Gutiérrez-Vázquez, C., Sánchez-Cabo, F., Pérez-Hernández, D., Vázquez, J., Martin-Cofreces, N., Martinez-Herrera, D. J., Pascual-Montano, A., Mittelbrunn, M., & Sánchez-Madrid, F.
- Venue
- Nature Communications
- Published
- 2013-12-20
- Volume
- 4
- Issue
- 1
- ISSN
- 2041-1723
- PMC
- PMC3905700
- Cited by
- 1,971
- References
- 5
- Language
- en
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