Cited by 1,971

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Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

Villarroya-Beltri, Carolina, Gutiérrez-Vázquez, Cristina, Sánchez-Cabo, Fátima, Pérez-Hernández, Daniel, Vázquez, Jesús, Martin-Cofreces, Noa, Martinez-Herrera, Dannys Jorge, Pascual-Montano, Alberto, Mittelbrunn, María, Sánchez-Madrid, Francisco·2013·Nature Communications

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Crossref · 10.1038/ncomms3980

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  • Known miRNA secretion motifs GGAG and AGG are not present in the miRNA sequences of hsa-mir-548 family members present in FF.

    “Known miRNA secretion motifs GGAG [34] and AGG [35] are not present in the miRNA sequences of hsa-mir-548 family members present in FF.”

    From Hsa-mir-548 family expression in human reproductive tissues (2021) · cites this paper as [34]

  • For miRNAs, both a non-selective secretion model and preferential or selective mechanisms of sorting into sEVs have been reported.

    “For miRNAs, both a non-selective secretion model [13] and preferential or selective mechanisms of sorting into sEVs have been reported [14–16].”
  • Sumoylated hnRNPA2B1 can specifically bind to a short GGAG sequence on miRNAs called an EXOmotif and transfer these miRNAs into exosomes.

    “Sumoylated heterogeneous nuclear ribonucleoprotein (hnRNPA2B1) can specifically bind to a short GGAG sequence on miRNAs called an EXOmotif and transfer these miRNAs into exosomes [16].”

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Research works printed but not linked: 43

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Metadata

Authors
Villarroya-Beltri, C., Gutiérrez-Vázquez, C., Sánchez-Cabo, F., Pérez-Hernández, D., Vázquez, J., Martin-Cofreces, N., Martinez-Herrera, D. J., Pascual-Montano, A., Mittelbrunn, M., & Sánchez-Madrid, F.
Venue
Nature Communications
Published
2013-12-20
Volume
4
Issue
1
ISSN
2041-1723
Cited by
1,971
References
5
Language
en

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