The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
P-selectin glycoprotein ligand-1–deficient mice have impaired leukocyte tethering to E-selectin under flow
Open accessAbstract
P-selectin glycoprotein ligand-1 (PSGL-1) mediates rolling of leukocytes on P-selectin under flow. The glycoproteins that enable leukocyte tethering to or rolling on E-selectin are not known. We used gene targeting to prepare PSGL-1-deficient (PSGL-1-/-) mice, which were healthy but had moderately elevated total blood leukocytes. Fluid-phase E-selectin bound to approximately 70% fewer sites on PSGL-1-/- than PSGL-1+/+ neutrophils. Compared with PSGL-1+/+ leukocytes, significantly fewer PSGL-1-/- leukocytes rolled on E-selectin in vitro, because their initial tethering to E-selectin was impaired. The residual cells that tethered rolled with the same shear resistance and velocities as PSGL-1+/+ leukocytes. Compared with PSGL-1+/+ mice, significantly fewer PSGL-1-/- leukocytes rolled on E-selectin in TNF-alpha-treated venules of cremaster muscle in which P-selectin function was blocked by an mAb. The residual PSGL-1-/- leukocytes that tethered rolled with slow velocities equivalent to those of PSGL-1+/+ leukocytes. These results reveal a novel function for PSGL-1 in tethering leukocytes to E-selectin under flow.
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Mechanisms That Regulate the Function of the Selectins and Their Ligands
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Self-citationZarbock, A., Ley, K., McEver, R. P., & Hidalgo, A. (2011) · Blood · doi:10.1182/blood-2011-07-343566 · Cited by 481
Self-citationSelectins promote tumor metastasis
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Wang, L., Fuster, M., Sriramarao, P., & Esko, J. D. (2005) · Nature Immunology · doi:10.1038/ni1233 · Cited by 413
Metadata
- Authors
- Xia, L., Sperandio, M., Yago, T., McDaniel, J. M., Cummings, R. D., Pearson-White, S., Ley, K., & McEver, R. P.
- Venue
- Journal of Clinical Investigation
- Published
- 2002-04-01
- Volume
- 109
- Issue
- 7
- Pages
- 939-950
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2159708686
- Cited by
- 230
- References
- 2
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Xia, L., Sperandio, M., Yago, T., McDaniel, J. M., Cummings, R. D., Pearson-White, S., Ley, K., & McEver, R. P. (2002). P-selectin glycoprotein ligand-1–deficient mice have impaired leukocyte tethering to E-selectin under flow. Journal of Clinical Investigation. https://doi.org/10.1172/jci14151
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