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Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses

Wang, Lianchun, Fuster, Mark, Sriramarao, P, Esko, Jeffrey D·2005·Nature Immunology
DOI 10.1038/ni1233
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Abstract

Here we have studied the involvement of endothelial heparan sulfate in inflammation by inactivating the enzyme N-acetyl glucosamine N-deacetylase-N-sulfotransferase-1 in endothelial cells and leukocytes, which is required for the addition of sulfate to the heparin sulfate chains. Mutant mice developed normally but showed impaired neutrophil infiltration in various inflammation models. These effects were due to changes in heparan sulfate specifically in endothelial cells. Decreased neutrophil infiltration was partially due to altered rolling velocity correlated with weaker binding of L-selectin to endothelial cells. Chemokine transcytosis across endothelial cells and presentation on the cell surface were also reduced, resulting in decreased neutrophil firm adhesion and migration. Thus, endothelial heparan sulfate has three functions in inflammation: by acting as a ligand for L-selectin during neutrophil rolling; in chemokine transcytosis; and by binding and presenting chemokines at the lumenal surface of the endothelium.

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Metadata

Authors
Wang, L., Fuster, M., Sriramarao, P., & Esko, J. D.
Venue
Nature Immunology
Publisher
Springer Science and Business Media LLC
Published
2005-07-31
Volume
6
Issue
9
Pages
902-910
ISSN
  • 1529-2908
  • 1529-2916
DOI
10.1038/ni1233
Cited by
413
References
3
Language
en
Licence
www.springer.com/tdm (tdm)

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