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Cited by 64SARS-CoV-2 and COVID-19 ResearchCOVID-19 Impact on ReproductionVaccine Coverage and Hesitancy

SARS-CoV-2 vaccine effectiveness in preventing confirmed infection in pregnant women

Open access
Butt, Adeel A., Chemaitelly, Hiam, Al Khal, Abdullatif, Coyle, Peter V., Saleh, Huda, Kaleeckal, Anvar H., Latif, Ali Nizar, Bertollini, Roberto +2 more·2021·Journal of Clinical Investigation
DOI 10.1172/jci153662PMC PMC8631593
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Abstract

BackgroundSARS-CoV-2 infection in pregnancy is associated with a higher risk of pregnancy-related complications and neonatal respiratory distress and hospitalization. Effectiveness of SARS-CoV-2 vaccines in pregnant women is not known.MethodsAll women with confirmed pregnancy who presented to the national referral hospital in Qatar between December 20, 2020, and May 30, 2021, with at least 1 SARS-CoV-2 test and not testing prior to pregnancy were included. We determined the vaccine effectiveness of mRNA vaccines in preventing confirmed SARS-CoV-2 infection during pregnancy using both cohort and test-negative case-control designs. Analyses were adjusted for age group, nationality, and gestational age.ResultsAmong 4534 pregnant women, there were 407 vaccinated and 407 unvaccinated women in the matched cohort analysis. Vaccine effectiveness was 87.6% (95%CI 44.1%-97.2%) at least 14 days after the second dose. There were 386 test-positive and 834 matched women in the test-negative case control analysis. Vaccine effectiveness was 86.8% (95%CI 47.5%-98.5%) at least 14 days after the second dose. Adjustment for age, nationality, and gestational age yielded similar results for both designs. In the test-negative analysis, vaccine effectiveness at least 14 days after the first dose but before the second dose was 40.8% (95% CI 0.0%-80.4%). Of the 386 test-positive pregnant women, 74 cases were Alpha variant, 163 cases were Beta variant, and 156 cases were variants of unknown status. The…

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Crossref · 10.1172/jci153662

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  • Effectiveness was assessed with a test-negative case-control design rather than a cohort design, but an earlier cohort study in the same population yielded similar findings.

    “Effectiveness was assessed with the use of an observational, test-negative, case–control design rather than a design in which cohorts of individual persons were followed up. However, the cohort study design applied earlier to the same population yielded findings similar to those of the test-negative design.14,15,31”

    From Effects of Previous Infection and Vaccination on Symptomatic Omicron Infections (2022) · cites this paper as [31]

  • The cohort study design applied earlier to the same population of Qatar yielded findings similar to those of the test-negative case-control design, supporting the validity of this standard approach in assessing vaccine effectiveness.

    “However, the cohort study design applied earlier to the same population of Qatar yielded findings similar to those of the test-negative case–control design36,38,39, supporting the validity of this standard approach in assessing vaccine effectiveness11,12,36,40.”

    From Duration of mRNA vaccine protection against SARS-CoV-2 Omicron BA.1 and BA.2 subvariants in Qatar (2022) · cites this paper as [39]

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Authors
Butt, A. A., Chemaitelly, H., Al Khal, A., Coyle, P. V., Saleh, H., Kaleeckal, A. H., Latif, A. N., Bertollini, R., Abou-Samra, A.-B., & Abu-Raddad, L. J.
Affiliations
  • Weill Cornell Medicine (US)
  • Hamad Medical Corporation (QA)
  • Ministry of Public Health (QA)
ORCID
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2021-12-01
Volume
131
Issue
23
ISSN
  • 0021-9738 (ISSN-L)
  • 1558-8238
DOI
10.1172/jci153662
PMC
PMC8631593
OpenAlex
W3203370784
Cited by
64
References
6
Citations by year
2026: 1 · 2025: 6 · 2024: 5 · 2023: 20 · 2022: 29 · 2021: 3
FWCI
4.51
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
None (N/A)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Obstetrics and Gynecology › COVID-19 Impact on Reproduction
  • Social Sciences › Health › Vaccine Coverage and Hesitancy
Keywords
SARS-CoV-2, COVID-19 vaccine effectiveness, pregnant women, mRNA vaccines, COVID-19 prevention, test-negative case-control design, cohort analysis, SARS-CoV-2 variants, Alpha variant, Beta variant, maternal immunization
MeSH terms
COVID-19, SARS-CoV-2, COVID-19 Vaccines, mRNA Vaccines, Adult, Female, Humans, Pregnancy, Pregnancy Complications, Infectious, Vaccination, Vaccines, Synthetic

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