The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Impaired renal Na+ retention in the sgk1-knockout mouse
Open accessAbstract
The serum- and glucocorticoid-regulated kinase (sgk1) is induced by mineralocorticoids and, in turn, upregulates heterologously expressed renal epithelial Na(+) channel (ENaC) activity in Xenopus oocytes. Accordingly, Sgk1 is considered to mediate the mineralocorticoid stimulation of renal ENaC activity and antinatriuresis. Here we show that at standard NaCl intake, renal water and electrolyte excretion is indistinguishable in sgk1-knockout (sgk1(-/-)) mice and wild-type (sgk1(+/+)) mice. In contrast, dietary NaCl restriction reveals an impaired ability of sgk1(-/-) mice to adequately decrease Na(+) excretion despite increases in plasma aldosterone levels and proximal-tubular Na(+) and fluid reabsorption, as well as decreases in blood pressure and glomerular filtration rate.
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Chang, S. S., Grunder, S., Hanukoglu, A., Rösler, A., Mathew, P. M., Hanukoglu, I., Schild, L., Lu, Y., Shimkets, R. A., Nelson-Williams, C., et al. (1996) · Nature Genetics · doi:10.1038/ng0396-248 · Cited by 808
Geller, D. S., Rodriguez-Soriano, J., Boado, A. V., Schifter, S., Bayer, M., Chang, S. S., & Lifton, R. P. (1998) · Nature Genetics · doi:10.1038/966 · Cited by 417
KOBAYASHI, T., DEAK, M., MORRICE, N., & COHEN, P. (1999) · Biochemical Journal · doi:10.1042/bj3440189 · Cited by 405
Cited by
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1
Wu, C., Yosef, N., Thalhamer, T., Zhu, C., Xiao, S., Kishi, Y., Regev, A., & Kuchroo, V. K. (2013) · Nature · doi:10.1038/nature11984 · Cited by 1,022
García-Martínez, J. M., & Alessi, D. R. (2008) · Biochemical Journal · doi:10.1042/bj20081668 · Cited by 907
(Patho)physiological Significance of the Serum- and Glucocorticoid-Inducible Kinase Isoforms
Lang, F., Böhmer, C., Palmada, M., Seebohm, G., Strutz-Seebohm, N., & Vallon, V. (2006) · Physiological Reviews · doi:10.1152/physrev.00050.2005 · Cited by 689
Self-citationSalt Sensitivity of Blood Pressure: A Scientific Statement From the American Heart Association
Elijovich, F., Weinberger, M. H., Anderson, C. A. M., Appel, L. J., Bursztyn, M., Cook, N. R., Dart, R. A., Newton-Cheh, C. H., Sacks, F. M., & Laffer, C. L. (2016) · Hypertension · doi:10.1161/hyp.0000000000000047 · Cited by 482
Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance
Qi, Z., Whitt, I., Mehta, A., Jin, J., Zhao, M., Harris, R. C., Fogo, A. B., & Breyer, M. D. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00324.2003 · Cited by 331
Metadata
- Authors
- Wulff, P., Vallon, V., Huang, D. Y., Völkl, H., Yu, F., Richter, K., Jansen, M., Schlünz, M., Klingel, K., Loffing, J., Kauselmann, G., Bösl, M. R., Lang, F., & Kuhl, D.
- Venue
- Journal of Clinical Investigation
- Published
- 2002-11-01
- Volume
- 110
- Issue
- 9
- Pages
- 1263-1268
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2124933226
- Cited by
- 353
- References
- 3
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Wulff, P., Vallon, V., Huang, D. Y., Völkl, H., Yu, F., Richter, K., Jansen, M., Schlünz, M., Klingel, K., Loffing, J., Kauselmann, G., Bösl, M. R., Lang, F., & Kuhl, D. (2002). Impaired renal Na+ retention in the sgk1-knockout mouse. Journal of Clinical Investigation. https://doi.org/10.1172/jci15696
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
