The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance
Abstract
Two nonradioactive methods for determining glomerular filtration rate (GFR) in conscious mice using FITC-labeled inulin (FITC-inulin) were evaluated. The first method measured GFR using clearance kinetics of plasma FITC-inulin after a single bolus injection. Based on a two-compartment model, estimated GFR was 236.69 ± 16.55 and 140.20 ± 22.27 μl/min in male and female C57BL/6J mice, respectively. Total or ⅚ nephrectomy reduced inulin clearance to 0 or 32.80 ± 9.32 μl/min, respectively. Conversely, diabetes mellitus induced by streptozotocin was associated with increased GFR. The other approach measured urinary inulin clearance using intraperitoneal microosmotic pumps to deliver FITC-inulin and metabolic cages to collect timed urine samples. This approach yielded similar GFR values of 211.11 ± 26.56 and 157.36 ± 20.02 μl/min in male and female mice, respectively. These studies demonstrate the feasibility of repeated nonisotopic measurement of inulin clearance in conscious mice.
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Cites
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Cited by
Mouse Models of Diabetic Nephropathy
Brosius, F. C., Alpers, C. E., Bottinger, E. P., Breyer, M. D., Coffman, T. M., Gurley, S. B., Harris, R. C., Kakoki, M., Kretzler, M., Leiter, E. H., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009070721 · Cited by 895
Self-citationFujita, H., Morii, T., Fujishima, H., Sato, T., Shimizu, T., Hosoba, M., Tsukiyama, K., Narita, T., Takahashi, T., Drucker, D. J., et al. (2014) · Kidney International · doi:10.1038/ki.2013.427 · Cited by 336
Renal elimination of perfluorocarboxylates (PFCAs)
Han, X., Nabb, D. L., Russell, M. H., Kennedy, G. L., & Rickard, R. W. (2012) · Chemical Research in Toxicology · doi:10.1021/tx200363w · Cited by 250
Corpe, C. P., Tu, H., Eck, P., Wang, J., Faulhaber-Walter, R., Schnermann, J., Margolis, S., Padayatty, S., Sun, H., Wang, Y., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39191 · Cited by 162
Chou, W.-C., & Lin, Z. (2019) · Environment International · doi:10.1016/j.envint.2019.03.058 · Cited by 98
Metadata
- Authors
- Qi, Z., Whitt, I., Mehta, A., Jin, J., Zhao, M., Harris, R. C., Fogo, A. B., & Breyer, M. D.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 2004-03
- Volume
- 286
- Issue
- 3
- Pages
- F590-F596
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2142503533
- Cited by
- 331
- References
- 34
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- closed
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