The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Increased ABCA1 activity protects against atherosclerosis
Open accessAbstract
The ABC transporter ABCA1 plays a key role in the first steps of the reverse cholesterol transport pathway by mediating lipid efflux from macrophages. Previously, it was demonstrated that human ABCA1 overexpression in vivo in transgenic mice results in a mild elevation of plasma HDL levels and increased efflux of cholesterol from macrophages. In this study, we determined the effect of overexpression of ABCA1 on atherosclerosis development. Human ABCA1 transgenic mice (BAC(+)) were crossed with ApoE(-/-) mice, a strain that spontaneously develop atherosclerotic lesions. BAC(+)ApoE(-/-) mice developed dramatically smaller, less-complex lesions as compared with their ApoE(-/-) counterparts. In addition, there was increased efflux of cholesterol from macrophages isolated from the BAC(+)ApoE(-/-) mice. Although the increase in plasma HDL cholesterol levels was small, HDL particles from BAC(+)ApoE(-/-) mice were significantly better acceptors of cholesterol. Lipid analysis of HDL particles from BAC(+)ApoE(-/-) mice revealed an increase in phospholipid levels, which was correlated significantly with their ability to enhance cholesterol efflux.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Cholesterol efflux from cells to apolipoprotein A-I (apoA-I) acceptors via the ATP-binding cassette transporters ABCA1 and ABCG1 is thought to be central in the antiatherogenic mechanism.”
From MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE −/− Mice (2012) · cites this paper as [12]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Studies in mice in which the Abca1 locus is either deleted or overexpressed generally have supported the hypothesis that ABCA1 significantly prevents atherosclerosis by maintaining circulating HDL-C levels and cellular cholesterol efflux.10–13”
From MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE −/− Mice (2012) · cites this paper as [12]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
The Metabolic and Molecular Bases of Inherited Disease
Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101
Havel, R. J., Eder, H. A., & Bragdon, J. H. (1955) · Journal of Clinical Investigation · doi:10.1172/jci103182 · Cited by 8,737
High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies.
Gordon, D. J., Probstfield, J. L., Garrison, R. J., Neaton, J. D., Castelli, W. P., Knoke, J. D., Jacobs, D. R., Bangdiwala, S., & Tyroler, H. A. (1989) · Circulation · doi:10.1161/01.cir.79.1.8 · Cited by 3,162
Molecular physiology of reverse cholesterol transport.
Fielding, C. J., & Fielding, P. E. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39898-9 · Cited by 1,448
Sterol-dependent Transactivation of theABC1 Promoter by the Liver X Receptor/Retinoid X Receptor
Costet, P., Luo, Y., Wang, N., & Tall, A. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003337200 · Cited by 981
High-Density Lipoproteins Inhibit Cytokine-Induced Expression of Endothelial Cell Adhesion Molecules
COCKERILL, G. W., Rye, K., Gamble, J. R., Vadas, M. A., & Barter, P. J. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.11.1987 · Cited by 788
Brodie, S. E. (1996) · Survey of Ophthalmology · doi:10.1016/s0039-6257(96)80075-0 · Cited by 770
Stary, H. C., Chandler, A. B., Glagov, S. K., Guyton, J. R., Insull, W., Rosenfeld, M. E., Schaffer, S. A., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.5.840 · Cited by 738
Scavenger Receptor BI Promotes High Density Lipoprotein-mediated Cellular Cholesterol Efflux
Ji, Y. I., Jian, B., Wang, N., Sun, Y., Moya, M. D. L. L., Phillips, M. C., Rothblat, G. H., Swaney, J. B., & Tall, A. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.20982 · Cited by 694
Flagged first, then by citations
Research works printed but not linked: 9
- Fielding, 1997, J Lipid Res, 38, 1503
- Fielding, 1995, J Lipid Res, 36, 211
- Rothblat, 1999, J Lipid Res, 40, 781
- Clee, 2000, J Lipid Res, 41, 521
- Lowry, 1951, J Biol Chem, 193, 265
- 10.1074/jbc.M102348200 · DOI
- Winkler, 1989, J Lipid Res, 30, 979
- Fournier, 1996, J Lipid Res, 37, 1704
- Costet, 2000, J Biol Chem, 275, 28240
Cited by
Sorted by citations
Items 201–249 of 249
A Subregion of Reelin Suppresses Lipoprotein-Induced Cholesterol Accumulation in Macrophages
Okoro, E. U., Zhang, H., Guo, Z., Yang, F., Smith, C., & Yang, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136895 · Cited by 13
Yin, Q.-X., Chang, H., Shen, Q., & Xing, D. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16531 · Cited by 12
Utilizing the LoxP-Stop-LoxP System to Control Transgenic ABC-Transporter Expression In Vitro
Esobi, I. C., Oladosu, O., Echesabal-Chen, J., & Stamatikos, A. (2022) · Biomolecules · doi:10.3390/biom12050679 · Cited by 12
Sha, Y.-H., Hu, Y., Gao, J.-J., Wang, Y., Ma, X., Qiu, Y., Li, S., Zhao, J., Huang, C., Zhao, J., et al. (2015) · Europe PMC (PubMed Central) · Cited by 12
Hafiane, A., Gianopoulos, I., Sorci‐Thomas, M. G., & Daskalopoulou, S. S. (2021) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000786 · Cited by 12
Liu, N., Hou, M., Ren, W., Cao, J., Wu, H., & Zhou, W. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-014-0161-8 · Cited by 11
Complete functional rescue of the ABCA1−/− mouse by human BAC transgenesis
Coutinho, J. M., Singaraja, R. R., Kang, M. H., Arenillas, D. J., Bertram, L. N., Bissada, N., Staels, B., Fruchart, J., Fiévet, C., Joseph‐George, A. M., et al. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400506-jlr200 · Cited by 11
Self-citationTorres-Paz, Y., Gamboa, R., Fuentevilla-Álvarez, G., Cardoso-Saldaña, G., Martínez-Alvarado, R., Soto, M. E., & Huesca-Gómez, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168605 · Cited by 7
Liu, L.-X., Zhang, M., Li, L., Li, C., Min, X., & Zheng, M. (2014) · Gynecologic and Obstetric Investigation · doi:10.1159/000362551 · Cited by 9
A novel enzyme immunoassay specific for ABCA1 protein quantification in human tissues and cells
Paul, V., Meyer, H. H. D., Leidl, K., Soumian, S., & Albrecht, C. (2008) · Journal of Lipid Research · doi:10.1194/jlr.d700040-jlr200 · Cited by 9
Gene Therapy of Atherosclerosis
Vähäkangas, E., & Ylä‐Herttuala, S. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-27661-0_30 · Cited by 8
Regulation of microRNA-33, SREBP and ABCA1 genes in a mouse model of high cholesterol
Zhang, X., Zhao, H., Sheng, Q., Liu, X., You, W., Lin, H., & Liu, G. (2021) · Archives animal breeding/Archiv für Tierzucht · doi:10.5194/aab-64-103-2021 · Cited by 7
Liver-directed gene therapy for dyslipidemia and diabetes
Oka, K., & Chan, L. (2004) · Current Atherosclerosis Reports · doi:10.1007/s11883-004-0033-6 · Cited by 7
Role of the ABC transporters ABCA1 and ABCG1 in foam cell formation and atherosclerosis
Meurs, I., Out, R., van Berkel, T. J. C., & Eck, M. V. (2008) · Future Lipidology · doi:10.2217/17460875.3.6.675 · Cited by 6
ATP-Binding Cassette Transporter A1 Polymorphisms and Haplotypes in Risk of Type 2 Diabetes
Saravani, R., Galavi, H. R., Ranjbar, N., & Alamdari, A. R. (2016) · Gene Cell and Tissue · doi:10.17795/gct-43677 · Cited by 6
Senanayake, C. M., Hapugaswatta, H., Samarawickrama, G. R., Jayathilaka, N., & Seneviratne, K. N. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13664 · Cited by 6
LXR activation and cholesterol efflux from a lipoprotein depot in vivo
Stein, Y., Stein, O., Dabach, Y., Halperin, G., & Ben-Naim, M. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2004.08.002 · Cited by 6
HDL Elevation and Lipid Lowering Therapy: Current Scenario and Future Perspectives
Chhabria, M. T., Suhagia, B. N., & Brahmkshatriya, P. S. (2007) · Recent Advances in Cardiovascular Drug Discovery (Formerly Recent Patents on Cardiovascular Drug Discovery) · doi:10.2174/157489007782418973 · Cited by 6
Wegner, C., Kim, B., & Lee, J. (2013) · Nutrients · doi:10.3390/nu5010208 · Cited by 5
El monocito/macrófago como diana terapéutica en la aterosclerosis
Pou, J., Rebollo, A., & Alegret, M. (2007) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/s0214-9168(07)74180-3 · Cited by 5
Toth, P. P. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-533-6_9 · Cited by 5
The Effect of 6 Weeks of Endurance Training on the Expression of Hepatic ABCA1 in Male Wistar Rats
Khabazian, B. M., Ghanbari–Niaki, A., Rahbarizadeh, F., Hosseini Kakhak, S. A. R., & Noghabi, M. J. (2008) · Cited by 5
Treating low HDL—From bench to bedside
Ng, D. S. (2004) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2004.04.005 · Cited by 4
van der Sluis, R. J., Verwilligen, R. A. F., Lendvai, Z., Wever, R., Hoekstra, M., & Eck, M. V. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.09.038 · Cited by 4
Chapter 1 Regulation of Metabolism by Nuclear Hormone Receptors
Huang, H.-J., & Schulman, I. G. (2009) · Progress in molecular biology and translational science · doi:10.1016/s1877-1173(09)87001-4 · Cited by 3
Cardiovascular DiseaseMouse Models of Atherosclerosis
MAEDA, N., CGIVENS, R., & LReddick, R. (2007) · Elsevier eBooks · doi:10.1016/b978-012369454-6/50070-4 · Cited by 3
Phospholipid transporters ABCA1 and ABCA7
Schmitz, G., & Kaminski, W. E. (2003) · Springer eBooks · doi:10.1007/978-1-4419-9023-5_19 · Cited by 3
Sun, Q., Zhang, L., Guo, S., Zheng, M., Yang, D., Zheng, C., Wu, J., Liu, J., & Wu, J. (2014) · Journal of Traditional Chinese Medical Sciences · doi:10.1016/j.jtcms.2014.11.007 · Cited by 2
Phenotypic High-Throughput Screening in Atherosclerosis Research: Focus on Macrophages
Muslin, A. J. (2010) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-010-9205-7 · Cited by 2
Gene-activators prevent and regress atherosclerosis and reduce mortality.
Luoma, P. (2009) · Cardiovascular & Hematological Agents in Medicinal Chemistry · doi:10.2174/187152509789541918 · Cited by 2
Hou, B., Huan, Z., Zhang, C., Chen, Z., Ha, L., & Huang, S.-X. (2022) · Folia Neuropathologica · doi:10.5114/fn.2022.114355 · Cited by 2
Genetics and molecular biology
Ikonen, E. (2005) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000194124.15216.e4 · Cited by 2
Sterol Efflux by ABCA1 and ABCG1
Terasaka, N. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-382171-3.10010-5 · Cited by 1
Pathogenesis of Atherosclerotic Vascular Disease
Basha, B. J., Bakris, G. L., & Sowers, J. R. (2005) · Humana Press eBooks · doi:10.1385/1-59259-881-1:099 · Cited by 1
Oram, J. F., & Heinecke, J. W. (2007) · Future Lipidology · doi:10.2217/17460875.2.2.185 · Cited by 1
Animal and cellular models for hypolipidemic drugs
Cignarella, A. (2008) · Expert Opinion on Drug Discovery · doi:10.1517/17460440802624987 · Cited by 1
Potential therapeutic agents that raise high-density lipoprotein cholesterol levels
Rodríguez, A., & Doshi, R. R. (2003) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.13.2.167 · Cited by 1
Genes That Modify Susceptibility to Atherosclerosis: Targets for Drug Action
Knowles, J. W. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-06214-2_4
THE EFFECTS OF HYPOMORPHIC SIALIDASE EXPRESSION ON ATHEROSCLEROSIS
Yang, A. (2012) · MacSphere (McMaster University) · doi:10.71548/14532
ABCA1, Tangier Disease, and Lipid Flopping
Zarubica, A., & Chimini, G. (2011) · Wiley eBooks · doi:10.1002/9781118120118.ch17 · Cited by 1
Sánchez, J. P. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Effects of oxidized low density lipoprotein on the expression and function of ABCA1 in macrophages
Ying-hon, L., Hao, B., Fan, W., Yiqiang, Z., Yan, W., & Qu, S. (2005) · Current Medical Science · doi:10.1007/bf02873552
Anti-atherogenic actions of dihomo-gamma-linolenic acid in macrophages
Gallagher, H. (2016) · ORCA Online Research @Cardiff (Cardiff University)
近藤, 彩. (2017) · 薬剤学 · doi:10.14843/jpstj.77.296
Associations of two general ABCA1 polymorphisms and risk of coronary heart disease in north of Iran
Molaeitabari, A., Mahmoudian, M., Khorasani, H. R., Jalali, S. F., Halalkhor, S., & Majidi, F. (2021) · Gene Reports · doi:10.1016/j.genrep.2021.101126
Larrède, S. (2008) · OpenGrey (Institut de l'Information Scientifique et Technique)
Naus, K. E., & Wellington, C. L. (2006) · Springer eBooks · doi:10.1007/0-387-36279-3_6
Bajpai, S. (2009) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/770d-5d08
Metadata
- Authors
- Singaraja, R. R., Fievet, C., Castro, G., James, E. R., Hennuyer, N., Clee, S. M., Bissada, N., Choy, J. C., Fruchart, J.-C., McManus, B. M., Staels, B., & Hayden, M. R.
- Affiliations
- University of British Columbia (CA)
- Inserm (FR)
- Corresponding author
- Hayden, Michael R.
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2002-07-01
- Volume
- 110
- Issue
- 1
- Pages
- 35-42
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC151034
- OpenAlex
- W2097061706
- Cited by
- 250
- References
- 45
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 11 · 2015: 9 · 2014: 9 · 2013: 10 · 2012: 8
- FWCI
- 22.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- ABCA1, atherosclerosis, reverse cholesterol transport, HDL cholesterol, macrophage cholesterol efflux, ApoE-deficient mice, transgenic mice, phospholipids, HDL particle composition, atherosclerotic plaque
- MeSH terms
- Animals, Apolipoproteins A, Apolipoproteins E, Arteriosclerosis, Biological Transport, Active, Cholesterol, Humans, Lipoproteins, HDL, Macrophages, Mice, Transgenic, Phospholipids, Tissue Distribution, Apolipoprotein A-I, Mice, Knockout, ATP-Binding Cassette Transporters, Mice, ATP Binding Cassette Transporter 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
