Molecular physiology of reverse cholesterol transport.
Open accessAbstract
Reverse cholesterol transport (RCT) is the pathway by which peripheral cell cholesterol can be returned to the liver for catabolism. Evidence of specific functions for molecular structures within individual plasma lipoprotein species has rapidly accumulated from recent studies using molecular and cellular physiology techniques. The removal of cholesterol from cells, like its delivery, appears to be specific and well regulated. Although further research will be needed, RCT can now be understood in molecular terms.
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CETP mediates the exchange of cholesterol and triglycerides between various lipoproteins and plays an important role in reverse cholesterol transport.
“Cholesteryl ester transfer protein (CETP) mediates the exchange of cholesterol and triglycerides between various lipoproteins and thus plays an important role in RCT (Fig. 2) [98, 99].”
From HDL cholesterol: reappraisal of its clinical relevance (2017) · cites this paper as [98]
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Temperature transitions of lipid mixtures containing cholesterol esters
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Francone, O. L., Fielding, C. J., & Fielding, P. E. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42106-6 · Cited by 28 · see citing works
Self-citationRoles of cysteines in human lecithin:cholesterol acyltransferase
Qu, S. J., Fan, H. Z., Blanco‐Vaca, F., et al. (1993) · Biochemistry · doi:10.1021/bi00063a021 · Cited by 28 · see citing works
Fielding, C. J., Castro, G. R., Donner, C. C., Fielding, P. E., & Reaven, G. M. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38764-2 · Cited by 28 · see citing works
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Lipoproteins containing apolipoprotein A-I extracted from human aortas
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Fielding, P. E., Miida, T., & Fielding, C. J. (1991) · Biochemistry · doi:10.1021/bi00099a009 · Cited by 25 · see citing works
Self-citationPieters, M. N., Castro, G. R., Schouten, D., Duchateau, P. N., Fruchart, J., & van Berkel, T. J. C. (1993) · Biochemical Journal · doi:10.1042/bj2920819 · Cited by 25 · see citing works
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Effect of LCAT on HDL-mediated cholesterol efflux from loaded EA.hy 926 cells
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Removal of lipoproteins from plasma
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Nascent astrocyte particles differ from lipoproteins in CSF
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HDL cholesterol: reappraisal of its clinical relevance
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- Authors
- Fielding, C. J., & Fielding, P. E.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1995-02
- Volume
- 36
- Issue
- 2
- Pages
- 211-228
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W1947043095
- Cited by
- 1,448
- References
- 128
- Citations by year
- 2026: 3 · 2025: 15 · 2024: 9 · 2023: 10 · 2022: 13 · 2021: 10 · 2020: 19 · 2019: 17 · 2018: 22 · 2017: 23 · 2016: 27 · 2015: 31 · 2014: 39 · 2013: 43 · 2012: 42
- FWCI
- 99.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institutes of Health (5p50hl014237-25)
- National Heart, Lung, and Blood Institute (HL 14237)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- reverse cholesterol transport, serum lipoproteins, cholesterol efflux, HDL cholesterol, molecular physiology, lipoprotein structure
- MeSH terms
- Amino Acid Sequence, Animals, Biological Transport, Active, Cell Membrane, Cholesterol, Humans, Phosphatidylcholine-Sterol O-Acyltransferase, Liver, Molecular Sequence Data, Apolipoprotein A-I
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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