Cited by 1,448Cholesterol and Lipid MetabolismDrug Transport and Resistance MechanismsLipid metabolism and disorders

Molecular physiology of reverse cholesterol transport.

Open access
Fielding, C J, Fielding, P E·1995·Journal of Lipid Research

Abstract

Reverse cholesterol transport (RCT) is the pathway by which peripheral cell cholesterol can be returned to the liver for catabolism. Evidence of specific functions for molecular structures within individual plasma lipoprotein species has rapidly accumulated from recent studies using molecular and cellular physiology techniques. The removal of cholesterol from cells, like its delivery, appears to be specific and well regulated. Although further research will be needed, RCT can now be understood in molecular terms.

Integrity signals

Registry

Crossref · 10.1016/s0022-2275(20)39898-9

Cites

128 of 128 references verified0 citation errors · 0 not checkable

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  • CETP mediates the exchange of cholesterol and triglycerides between various lipoproteins and plays an important role in reverse cholesterol transport.

    “Cholesteryl ester transfer protein (CETP) mediates the exchange of cholesterol and triglycerides between various lipoproteins and thus plays an important role in RCT (Fig. 2) [98, 99].”

    From HDL cholesterol: reappraisal of its clinical relevance (2017) · cites this paper as [98]

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Authors
Fielding, C. J., & Fielding, P. E.
Affiliations
University of California, San Francisco (US)
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
1995-02
Volume
36
Issue
2
Pages
211-228
ISSN
0022-2275 (ISSN-L)
OpenAlex
W1947043095
Cited by
1,448
References
128
Citations by year
2026: 3 · 2025: 15 · 2024: 9 · 2023: 10 · 2022: 13 · 2021: 10 · 2020: 19 · 2019: 17 · 2018: 22 · 2017: 23 · 2016: 27 · 2015: 31 · 2014: 39 · 2013: 43 · 2012: 42
FWCI
99.71
Type
journal article
Language
en
Open access
Locations
  • Journal of Lipid Research (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Institutes of Health (5p50hl014237-25)
  • National Heart, Lung, and Blood Institute (HL 14237)
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
reverse cholesterol transport, serum lipoproteins, cholesterol efflux, HDL cholesterol, molecular physiology, lipoprotein structure
MeSH terms
Amino Acid Sequence, Animals, Biological Transport, Active, Cell Membrane, Cholesterol, Humans, Phosphatidylcholine-Sterol O-Acyltransferase, Liver, Molecular Sequence Data, Apolipoprotein A-I

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