The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Do oxysterols control cholesterol homeostasis?
Open accessAbstract
Oxysterols are oxygenated derivatives of cholesterol with a very short half-life relative to cholesterol.As a consequence they are present in very low concentrations in all mammalian systems, almost invariably accompanied by 10 3 -to 10 6 -fold excess of cholesterol.Oxysterols are important intermediates in a number of hepatic and extrahepatic catabolic pathways, most of which generate water-soluble bile acids as final products.Based on largely indirect evidence, and in spite of their low levels in vivo, oxysterols are generally believed to be important physiological mediators of cholesterol-induced effects.Perhaps the best support for this model is the existence of nuclear receptors that bind these compounds with high affinity and the fact that oxysterols potently regulate the expression of sterol-sensitive genes in vitro.Here I consider the role of oxysterols as intermediates in different catabolic pathways, and I weigh the evidence for and against the "oxysterol hypothesis" of cholesterol homeostasis.
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Cites
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway
Lehmann, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J.-L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3137 · Cited by 1,233
Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
Pitas, R. E., Boyles, J. K., Lee, S. H., Foss, D., & Mahley, R. W. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90295-5 · Cited by 693
Lund, E. G., Kerr, T. A., Sakai, J., Li, W.-P., & Russell, D. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.34316 · Cited by 335
Cited by
Brain Cholesterol: Long Secret Life Behind a Barrier
Björkhem, I., & Meaney, S. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000120374.59826.1b · Cited by 1,044
Regulation of Sterol Synthesis in Eukaryotes
Espenshade, P. J., & Hughes, A. L. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130315 · Cited by 593
Radhakrishnan, A., Ikeda, Y., Kwon, H. J., Brown, M. S., & Goldstein, J. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700899104 · Cited by 556
Malformation syndromes caused by disorders of cholesterol synthesis
Porter, F. D., & Herman, G. E. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r009548 · Cited by 473
Lund, E. G., Xie, C., Kotti, T., Turley, S. D., Dietschy, J. M., & Russell, D. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303415200 · Cited by 421
Metadata
- Authors
- Björkhem, I.
- Venue
- Journal of Clinical Investigation
- Published
- 2002-09-15
- Volume
- 110
- Issue
- 6
- Pages
- 725-730
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2044112399
- Cited by
- 224
- References
- 4
- FWCI
- 8.77
- Type
- journal article
- Language
- en
- Open access
- green
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