The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Randall’s plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle
Open accessAbstract
Our purpose here is to test the hypothesis that Randall's plaques, calcium phosphate deposits in kidneys of patients with calcium renal stones, arise in unique anatomical regions of the kidney, their formation conditioned by specific stone-forming pathophysiologies. To test this hypothesis, we performed intraoperative biopsies of plaques in kidneys of idiopathic-calcium-stone formers and patients with stones due to obesity-related bypass procedures and obtained papillary specimens from non-stone formers after nephrectomy. Plaque originates in the basement membranes of the thin loops of Henle and spreads from there through the interstitium to beneath the urothelium. Patients who have undergone bypass surgery do not produce such plaque but instead form intratubular hydroxyapatite crystals in collecting ducts. Non-stone formers also do not form plaque. Plaque is specific to certain kinds of stone-forming patients and is initiated specifically in thin-limb basement membranes by mechanisms that remain to be elucidated.
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Cites
The Pathogenesis and Treatment of Kidney Stones
Coe, F. L., Parks, J. H., & Asplin, J. R. (1992) · New England Journal of Medicine · doi:10.1056/nejm199210153271607 · Cited by 696
Self-citationEquil2: A Basic Computer Program for the Calculation of Urinary Saturation
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Familial Idiopathic Hypercalciuria
Coe, F. L., Parks, J. H., & Moore, E. S. (1979) · New England Journal of Medicine · doi:10.1056/nejm197902153000703 · Cited by 272
Self-citationHISTOCHEMICAL IDENTIFICATION OF CALCIUM OXALATE
YASUE, T. (1969) · ACTA HISTOCHEMICA ET CYTOCHEMICA · doi:10.1267/ahc.2.83 · Cited by 196
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Cited by
Gower, L. B. (2008) · Chemical Reviews · doi:10.1021/cr800443h · Cited by 1,086
Randall’s plaque and calcium oxalate stone formation: role for immunity and inflammation
Khan, S. R., Canales, B. K., & Dominguez-Gutierrez, P. R. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-020-00392-1 · Cited by 423
Herbal remedies for urinary stones used in India and China: A review
Kasote, D. M., Jagtap, S. D., Thapa, D., Khyade, M. S., & Russell, W. R. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.03.038 · Cited by 125
Oxalate in renal stone disease: the terminal metabolite that just won't go away
Marengo, S. R., & Romani, A. M. (2008) · Nature Clinical Practice Nephrology · doi:10.1038/ncpneph0845 · Cited by 106
Genetic variants predisposing to an increased risk of kidney stone disease
Lovegrove, C. E., Goldsworthy, M., Haley, J., Smelser, D., Gorvin, C., Hannan, F. M., Mahajan, A., Suri, M., Sadeghi-Alavijeh, O., Moochhala, S. H., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci186915 · Cited by 18
Metadata
- Authors
- Evan, A. P., Lingeman, J. E., Coe, F. L., Parks, J. H., Bledsoe, S. B., Shao, Y., Sommer, A. J., Paterson, R. F., Kuo, R. L., & Grynpas, M.
- Venue
- Journal of Clinical Investigation
- Published
- 2003-03-01
- Volume
- 111
- Issue
- 5
- Pages
- 607-616
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2115985004
- Cited by
- 616
- References
- 6
- FWCI
- 23.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Randall’s plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle. https://app.cochat.ai/papers/10.1172/jci17038
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- Evan, A. P., Lingeman, J. E., Coe, F. L., Parks, J. H., Bledsoe, S. B., Shao, Y., Sommer, A. J., Paterson, R. F., Kuo, R. L., & Grynpas, M. (2003). Randall’s plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle. Journal of Clinical Investigation. https://doi.org/10.1172/jci17038
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
