Cited by 765Cardiac Fibrosis and RemodelingCell death mechanisms and regulationCardiac Ischemia and Reperfusion

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

A mechanistic role for cardiac myocyte apoptosis in heart failure

Open access

Wencker, Detlef, Chandra, Madhulika, Nguyen, Khanh, Miao, Wenfeng, Garantziotis, Stavros, Factor, Stephen M., Shirani, Jamshid, Armstrong, Robert C., Kitsis, Richard N.·2003·Journal of Clinical Investigation

DOI 10.1172/jci17664PMC PMC155051

Open this paper in CoChat — free account Open PDF

Abstract

Heart failure is a common, lethal condition whose pathogenesis is poorly understood. Recent studies have identified low levels of myocyte apoptosis (80-250 myocytes per 10(5) nuclei) in failing human hearts. It remains unclear, however, whether this cell death is a coincidental finding, a protective process, or a causal component in pathogenesis. Using transgenic mice that express a conditionally active caspase exclusively in the myocardium, we demonstrate that very low levels of myocyte apoptosis (23 myocytes per 10(5) nuclei, compared with 1.5 myocytes per 10(5) nuclei in controls) are sufficient to cause a lethal, dilated cardiomyopathy. Interestingly, these levels are four- to tenfold lower than those observed in failing human hearts. Conversely, inhibition of cardiac myocyte death in this murine model largely prevents the development of cardiac dilation and contractile dysfunction, the hallmarks of heart failure. To our knowledge, these data provide the first direct evidence that myocyte apoptosis may be a causal mechanism of heart failure, and they suggest that inhibition of this cell death process may constitute the basis for novel therapies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci17664

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Caspases: Enemies Within
Thornberry, N. A., & Lazebnik, Y. A. (1998) · Science · doi:10.1126/science.281.5381.1312 · Cited by 6,857
Apoptosis in the Failing Human Heart
Olivetti, G., Abbi, R., Quaini, F., Kajstura, J., Cheng, W., Nitahara, J. A., Quaini, E., Di Loreto, C., Beltrami, C. A., Krajewski, S., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361603 · Cited by 1,673
Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme
Kuida, K., Lippke, J. A., Ku, G., Harding, M. W., Livingston, D. J., Su, M. S. S., & Flavell, R. A. (1995) · Science · doi:10.1126/science.7535475 · Cited by 1,631
Apoptosis in Myocytes in End-Stage Heart Failure
Narula, J., Haider, N., Virmani, R., DiSalvo, T. G., Kolodgie, F. D., Hajjar, R. J., Schmidt, U., Semigran, M. J., Dec, G. W., & Khaw, B.-A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610173351603 · Cited by 1,430
Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock
Li, P., Allen, H., Banerjee, S., Franklin, S., Herzog, L., Johnston, C. G., McDowell, J., Paskind, M. P., Rodman, L., Salfeld, J. G., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90490-5 · Cited by 1,408
Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme
Gu, Y., Kuida, K., Tsutsui, H., Ku, G., Hsiao, K., Fleming, M. A., Hayashi, N., Higashino, K., Okamura, H., Nakanishi, K., et al. (1997) · Science · doi:10.1126/science.275.5297.206 · Cited by 1,159
An Induced Proximity Model for Caspase-8 Activation
Muzio, M., Stockwell, B. R., Stennicke, H. R., Salvesen, G. S., & Dixit, V. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.2926 · Cited by 1,023
Caspase activation: The induced-proximity model
Salvesen, G. S., & Dixit, V. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.10964 · Cited by 932
Controlling Signal Transduction with Synthetic Ligands
Spencer, D. M., Wandless, T. J., Schreiber, S. L., & Crabtree, G. R. (1993) · Science · doi:10.1126/science.7694365 · Cited by 845
Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.
Luo, W., Grupp, I. L., Harrer, J. M., Ponniah, S., Grupp, G., Duffy, J. J., Doetschman, T., & Kranias, E. G. (1994) · Circulation Research · doi:10.1161/01.res.75.3.401 · Cited by 706

Show all 29 references

Research works printed but not linked: 2

Walter, 1989, Biotechniques., 7, 1065
Li, 1997, Am. J. Physiol., 272, H2313

Sorted by citations

Items 601–700 of 765

Oxidative stress mediated cardiac apoptosis
Kara, M., Özçağlı, E., Jannuzzi, A. T., & Alpertunga, B. (2015) · DergiPark (Istanbul University) · doi:10.16883/jfpiu.94532 · Cited by 5
Elevated Troponins and Diagnosis of Non-ST-Elevation Myocardial Infarction in the Emergency Department
Ali, F., Arshad, K., Szpunar, S., & Daher, E. (2024) · Cureus · doi:10.7759/cureus.59910 · Cited by 4
Isquemia miocárdica: conceptos básicos, diagnóstico e implicaciones clínicas. Segunda parte
Moreno, P., & Portillo, J. H. D. (2016) · Revista Colombiana de Cardiología · doi:10.1016/j.rccar.2016.01.024 · Cited by 4
Cardiac Aging
Dai, D., Wessells, R. J., Bodmer, R., & Rabinovitch, P. S. (2009) · Springer eBooks · doi:10.1007/978-90-481-3465-6_12 · Cited by 4
Genetic deletion of calcium/calmodulin-dependent protein kinase type II delta does not mitigate adverse myocardial remodeling in volume-overloaded hearts
Mohamed, B. A., Elkenani, M., Jakubiczka-Smorag, J., Buchholz, E., Koszewa, S., Lbik, D., Schnelle, M., Hasenfuss, G. P., & Toischer, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-46332-3 · Cited by 4
Cell Therapy in Heart Failure
Pfister, O., Jain, M., & Liao, R. (2005) · Heart Failure Clinics · doi:10.1016/j.hfc.2005.03.003 · Cited by 4
A New Dual-Promoter System for Cardiomyocyte-Specific Conditional Induction of Apoptosis
Agostini, S., Lionetti, V., Matteucci, M., Chiuppesi, F., Giacca, M., Pistello, M., & Recchia, F. A. (2013) · BioMed Research International · doi:10.1155/2013/845816 · Cited by 4
Cardioprotective Effects of 3-Phosphoinositide-Dependent Protein Kinase-1 on Hypoxic Injury in Cultured Neonatal Rat Cardiomyocytes and Myocardium in a Rat Myocardial Infarct Model
Shim, T. J., Bae, J., Yeon-Jung, K. I. M., Kim, D. J., Hwang, K., Kim, D. W., & Cho, M. (2012) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.110562 · Cited by 4
Molecular and Cellular Events in Myocardial Hypertrophy and Failure
Sawyer, D. B., & Colucci, W. S. (2002) · doi:10.1007/978-1-4615-6490-4_4 · Cited by 4
Bioinformatic analysis of microarray data reveals several key genes related to heart failure.
Zhang, Z., Cao, H., Liu, G., Fan, H.-M., & Liu, Z.-M. (2013) · PubMed · Cited by 4
Cardiac Aging
Dai, D., Chiao, Y. A., Wessells, R. J., Bodmer, R., Szeto, H. H., & Rabinovitch, P. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-411596-5.00017-4 · Cited by 4
Kinase inhibitor-induced cardiotoxicity assessed in vitro with human pluripotent stem cell derived cardiomyocytes
Xian, H.-Q., Blanco, C., Bonham, K., & Snodgrass, H. R. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.115886 · Cited by 4
Mending a broken heart—targeting cardiomyocyte regeneration: a literature review
Jin, C., Zhu, S., Zhao, T., Deng, J., Xiang, M., & Ma, H. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-2649 · Cited by 3
Cardiac protection of wogonin in mice with pulmonary fibrosis by regulating Sirt1/ γ-H2AX pathway
Wang, L., Lin, F., Miao, R., Zhao, T., Liu, Y., Yang, L., & Zhang, M. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1551141 · Cited by 3
Myocardial Na+ K+-ATPase and SERCA: Clinical and Pathological Significance From a Cytological Perspective
Labudović‐Borović, M., Obradovic, M. M., Kostić, J. T., Zaletel, I. V., Milašinović, D., Stojanović, M. T., Mutavdžin, S., Vesković, M. N., Opačić, D., Radaković, D., et al. (2015) · Springer eBooks · doi:10.1007/978-3-319-24750-2_7 · Cited by 3
Role of Cardiomyocyte Apoptosis in Heart Failure
Bhullar, S. K., Shah, A. K., & Dhalla, N. S. (2021) · Advances in biochemistry in health and disease · doi:10.1007/978-3-030-78799-8_14 · Cited by 3
Epac1 participates in β1-adrenoreceptor autoantibody-mediated decreased autophagic flux in cardiomyocytes
Yang, L., Tian, Y., Shi, S., Hou, X., Hao, H., Ma, M., Ning, N., Yuan, Y., Wang, X., Liu, H., et al. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119512 · Cited by 3
LARP7 Contributes to Glucose-Induced Cardiac Dysfunction, Apoptosis and Fibrosis by Inhibiting the Degradation of STING
Sun, J., Wang, Z., Duan, Y., Liu, C., Zhao, S., & Deng, J. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2907274 · Cited by 4
The Cardiomyocyte in Cirrhosis: Pathogenic Mechanisms Underlying Cirrhotic Cardiomyopathy
Ryu, D. G., Yu, F., Yoon, K. T., Liu, H., & Lee, S. S. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2512457 · Cited by 3
Gene and protein-based therapies for improving cardiac performance and regeneration
Katz, M. G., Gubara, S. M., Bridges, C. R., Hajjar, R. J., & Fargnoli, A. S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813706-2.00016-6 · Cited by 3
Peripartum Cardiomyopathy: A Systematic Review
Aursulesei, V. O., & Dan, M. (2012) · InTech eBooks · doi:10.5772/27565 · Cited by 3
Overexpression of copper/zinc superoxide dismutase in the median preoptic nucleus improves cardiac function after myocardial infarction in the rat
Collister, J. P., Hartnett, C., Mayerhofer, T., Nahey, D. B., Stauthammer, C. D., Krüger, M., Tobias, A. H., O’Sullivan, M. G., Parker, J., Tian, J., et al. (2016) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12607 · Cited by 3
Non-steroidal anti-inflammatory drugs and increased risk of sudden cardiac death
Hwang, S. M., Gilda, J. E., Cui, Z., & Gomes, A. V. (2013) · Cited by 3
Cardiac Remodeling and Regeneration
Seeger, T., Chen, C. S., Karakikes, I., & Wu, J. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-44733-1.00030-4 · Cited by 4
From cell to heart: the impact of the cell organelles dysfunction on heart disease
Tsipis, A., Athanassiadou, A. M., Petrou, E., Miliopoulos, D., Athanassiadou, P. P., Kavantzas, N., & Athanassopoulos, G. D. (2018) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000628 · Cited by 3
Human menstrual blood–derived stem cells protect H9c2 cells against hydrogen peroxide–associated apoptosis
Chen, S., Dong, C., Zhang, J., Tang, B., Xi, Z., Cai, F., Gong, Y., Xu, J., Qi, L., Wang, Q., et al. (2019) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-018-0311-1 · Cited by 3
Effect of High-Intensity Interval Training on Apoptotic Gene Expression in Rat Myocardial Tissue
Pourrazi, H., Asgharpour-Arshad, M., Gholami, F., & Abbasi, S. (2020) · Gene Cell and Tissue · doi:10.5812/gct.101963 · Cited by 3
Pathophysiologie der Herzinsuffizienz
Kempf, T., Drexler, H., & Wollert, K. C. (2007) · Der Internist · doi:10.1007/s00108-007-1929-3 · Cited by 3
Predictive medicine in non-malignant urological disorders
Mancini, M., Cisternino, A., Tavolini, I. M., Moro, F. D., & Bassi, P. (2004) · World Journal of Urology · doi:10.1007/s00345-003-0381-9 · Cited by 3
Stresses of a failing heart
Kirshenbaum, L. A. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00239-6 · Cited by 3
Aerobic Exercise and Nano-curcumin Supplementation Prevent cancer symptom development through MAPK/ERK pathwayPreprint
Ababd, Z. V. M., Chaman, N. H., Hosseini, M., & Maleki, A. H. (2023) · Research Square · doi:10.21203/rs.3.rs-3257588/v1 · Cited by 3
Mise au point sur la génétique de la cardiomyopathie dilatée familiale
Amara, M. E. O., Villard, E., & Michel Komajda, N. (2004) · Annales de Cardiologie et d Angéiologie · doi:10.1016/j.ancard.2004.09.005 · Cited by 2
A Need to Preserve Ejection Fraction during Heart Failure
Akinterinwa, O. E., Singh, M., Vemuri, S., & Tyagi, S. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168780 · Cited by 2
CHRONIC HEART FAILURE EPIDEMIOLOGY IN KAZAKHSTAN AND OTHER COUNTRIES
Bashirov, A. U. (2024) · Ulyanovsk Medico-biological Journal · doi:10.34014/2227-1848-2024-3-17-27 · Cited by 2
Green tea epigallocatechin gallate and its impact on heart health
Li, Y. (2024) · Tea in Health and Disease Prevention · doi:10.1016/b978-0-443-14158-4.00048-8 · Cited by 2
Platycodin D (PD) attenuates myocardial apoptosis mediated by JNK-SIRT1-HSF1-IGF-IIR-Caspase-3 signaling in hypertensive conditions
Lin, Y.-C., Lin, Y., Kuo, W., Shen, C.-Y., Chen, Y.-F., Lin, Y.-M., Ho, T., Padma, V. V., Huang, C., & Huang, C.-Y. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.04.008 · Cited by 2
Heart Muscle and Apoptosis
Tsipis, A. (2012) · InTech eBooks · doi:10.5772/29360 · Cited by 2
Risk and safety assessment of exogenous human brain natriuretic peptide in cynomolgus monkeys (Macaca fascicularis)—A subchronic study
Mao, Y., Zhao, Y. Z., Zhang, X., Zheng, J., Lu, G., & Yuan, B. (2009) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2009.09.010 · Cited by 2
The importance of apoptotic activity and plasma NT-proBNP levels in patients with acute exacerbation of decompensated heart failure and their relation to different drugs and comorbidities.
Sarimehmetoglu, A. C., Gültekin, N., Küçükateş, E., Yıldız, A., Koçaş, C., & Ersanli, M. K. (2014) · PubMed · Cited by 2
The Cardiac Re-AKT-Ion to Chronic Volume Overload
Maack, C. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.523 · Cited by 2
Novel Therapeutic Targets and Strategies against Myocardial Diseases
Naito, A. T., Shiojima, I., & Komuro, I. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381510-1.00051-x · Cited by 2
Tonifying qi and Warming yang, a compound traditional Chinese herbal medicine, suppresses AngII-induced cardiac H9c2 cells apoptosis through regulating PI3K/Akt signaling pathway
Zou, G., Zhong, W.-L., Jin, J., Sui, Y.-B., & Liu, L. (2017) · Medicinal Chemistry Research · doi:10.1007/s00044-017-2043-2 · Cited by 2
Contribution of volume overload to progression of cardiovascular disease in a rat model of chronic kidney disease
Mahmoud, M. M., ShamsEldeen, A. M., Rashed, L. A., Fares, A. E., Shamaa, A., & Gharib, D. M. (2018) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0070 · Cited by 2
Actualización en los mecanismos fisiopatológicos de la insuficiencia cardiaca
Ulate, G., & Campos, A. U. (2009) · Acta Médica Costarricense · doi:10.51481/amc.v50i1.345 · Cited by 2
Is cell death a prerequisite for cardiac dysfunction during sepsis?*
Crouser, E. D. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000159727.27059.d2 · Cited by 2
From the Laboratory to the Clinic: Molecular Treatment of Heart Failure
Alagoz, M., & Alpay, M. (2024) · Düzce Tıp Fakültesi Dergisi · doi:10.18678/dtfd.1435020 · Cited by 1
Influence of sex and degree of prematurity on the heart structure in the late postnatal period of ontogenesis
Иванова, В. В., Serebryakova, O. N., Erokhina, А. V., Nikonova, A. D., & Васильевич, М. И. (2024) · Morphology · doi:10.17816/morph.629276 · Cited by 1
Mixture effect of parental exposure to triazophos and fenvalerate on the early development of zebrafish offspring
Cang, T., Huang, N., Nie, D., Chen, L., Shao, K., Wu, C., Chen, C., & Wang, Y. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.143415 · Cited by 4
A computational model of age‐dependent cardiomyocyte apoptosis
Kutumova, E. O., Kiselev, I. N., & Kolpakov, F. (2025) · The Journal of Physiology · doi:10.1113/jp288853 · Cited by 2
Infiltrative and Inflammatory Cardiomyopathies: Using Imaging to Probe Mechanisms of Myocardial Dysfunction
Rojulpote, C., Givertz, M. M., Mitchell, R. N., Padera, R. F., Kwong, R. Y., Divakaran, S., & Dorbala, S. (2026) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2026.02.024 · Cited by 1
Regulated cell death programs shaping cancer therapy
Luo, H., & Guo, Y. (2026) · Cellular Oncology · doi:10.1007/s13402-026-01232-3 · Cited by 1
Apoptosis Imaging in Diseased Myocardium
Taki, J., Wakabayashi, H., Inaki, A., Matsunari, I., & Kinuy, S. (2011) · InTech eBooks · doi:10.5772/25292 · Cited by 1
Programmed Cardiomyocyte Death in Heart Disease
Dorn, G. W., & Kitsis, R. N. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381510-1.00031-4 · Cited by 1
Self-citation
Cardiac MRI and PET Scanning in Right Ventricular Failure
van de Veerdonk, M. C., Marcus, J. T., Bogaard, H. J., & Noordegraaf, A. V. (2014) · Respiratory medicine · doi:10.1007/978-1-4939-1065-6_12 · Cited by 1
[Pathophysiologic role of myocardial hypertrophy, microcirculatory dysfunction and cardiomyocyte apoptosis in aortic stenosis].
Lotrionte, M., Galiuto, L., Biondi‐Zoccai, G., & Abbate, A. (2006) · PubMed · Cited by 1
Donor myocardial apollon mRNA is associated with cardiac allograft rejection
Aharinejad, S., Andrukhova, O., Gmeiner, M., Thomas, A., Aliabadi, A. Z., Zuckermann, A. O., & Grimm, M. F. (2010) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2010.03.011 · Cited by 1
Mechanisms of Cardiac Cell Death
Euler, G. (2016) · Springer eBooks · doi:10.1007/978-3-319-31251-4_9 · Cited by 1
Amelioration of myocardial apoptosis by using Ocimum basilicum in rats after exposure to electromagnetic field (EMF): light and transmission microscopic study
Khaki, A. A., & Khaki, A. (2012) · Cited by 1
Pharmacological Agents in the Clinic: Trial and Error
Fiedler, L. R. (2015) · Heart Research - Open Journal · doi:10.17140/hroj-2-122 · Cited by 1
Role of Kruppel-like Factor 8 (KLF8) in Cancer and Cardiomyopathy
Lahiri, S. K. (2016) · Journal of International Crisis and Risk Communication Research · Cited by 1
Cirrhotic Cardiomyopathy: Pathogenic Mechanisms and Management Strategies
Liu, H., & Lee, S. S. (2015) · Springer eBooks · doi:10.1007/978-3-319-13614-1_17 · Cited by 1
Results of treatment of inoperable recurrences of laryngeal cancer after total laryngectomy.
Sas-Korczyńska, B., Korzeniowski, S., & Skołyszewski, J. (1996) · PubMed · Cited by 1
Cardiac Microvascular Endothelial Cells and Pressure Overload-Induced Cardiac Fibrosis
Al‐Hasani, J., & Hecker, M. (2023) · Cardiac and vascular biology · doi:10.1007/978-3-031-23965-6_10 · Cited by 1
Cardiac Plasticity in Health and Disease
Gondalia, R., Rothermel, B. A., Lavandero, S., Gillette, T. G., & Hill, J. A. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-891-7_7 · Cited by 1
Myocardial Cell Death and Regeneration
Blanc-Brude, O. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-4927-2.00009-8
Myocardial Basis for Heart Failure
Jha, S. K., & Kitsis, R. N. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5895-3.10006-3 · Cited by 1
Self-citation
Cardiomyocytes in Heart Failure
Kartha, C. C. (2021) · Springer eBooks · doi:10.1007/978-3-030-85536-9_15 · Cited by 1
A Protein-Centric Perspective of Autophagy and Apoptosis Signaling and Crosstalk in Health and Disease
Wang, D., Lee, J., Polson, J., Liem, D. A., & Ping, P. (2021) · Advances in biochemistry in health and disease · doi:10.1007/978-3-030-78799-8_1 · Cited by 1
Development of targeted gene delivery vectors to assess cardiac overexpresion of ACE2 in vivo
Shirley, R. (2008) · Enlighten: Theses (The University of Glasgow) · Cited by 1
Nix : The Cardiac Styx Between Life and Death
Martins, P. A. D. C., & Windt, L. J. D. (2008) · Circulation · doi:10.1161/circulationaha.107.750125 · Cited by 1
Longitudinal trends in sFas, a biomarker of apoptosis, after an acute coronary syndrome: Clues to the pathogenesis underlying adverse events on follow-up
Cardinal, H., Madore, F., Brophy, J. M., Joseph, L., Hébert, M., Min, S., Boyer, L., & Bogaty, P. M. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.03.139 · Cited by 1
Self-annihilation
Henke, K., & Eigsti, J. E. (2005) · Dimensions of Critical Care Nursing · doi:10.1097/00003465-200505000-00003 · Cited by 1
Apoptosis in Cardiovascular Pathogenesis
el Azzouzi, H., Bourajjaj, M., Martins, P. A. D. C., & Windt, L. J. D. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-381-7_22 · Cited by 1
Impact of excess adiposity on blood pressure and cardiovascular target organ damage
Majane, O. H. I. (2009) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg) · Cited by 1
Molecular mechanisms of cardiac myocyte death
Mani, K. M., Crow, M. T., & Kitsis, R. N. (2005) · CRC Press eBooks · doi:10.3109/9780203503249-5 · Cited by 1
Self-citation
Examining Autophagy and Mitophagy as Inducible Mechanisms of Cellular Remodelling
Bloemberg, D. (2017) · UWSpace (University of Waterloo) · Cited by 1
Zum Einfluss von DYRK1A auf den aktivierten Calcineurin/NFAT-Signalweg und die Hypertrophie in Kardiomyozyten
Grau, S. P. (2012) · doi:10.53846/goediss-1527 · Cited by 1
Myocardial-derived small extracellular vesicles spontaneously released from living myocardial slices under biomimetic culture conditions regulate contractility and cardiac remodellingPreprint
Nicastro, L., Lal, A., Kyriakou, A., Kholia, S., Toldra, R. N., Downing, B., Kermani, F., Anwar, M., Martino, F., Chokron, D., et al. (2024) · medRxiv · doi:10.1101/2024.02.09.24302607 · Cited by 1
Hipertrofia cardíaca patológica: estudio experimental de su modificación con el ejercicio-vías de señalización intracelular involucradas
Nolly, M. B. (2012) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/2767
Quellen und Effekte reaktiver Sauerstoffspezies in Herzmuskelzellen
Cura, A. A. (2014) · Publications of the UdS (Saarland University) · doi:10.22028/d291-21986
Neonatal rat ventricular myocytes force mapping using double-sided micropillar arrays
Zhang, F., Ren, D., You, Z., Anderson, S. W., & Zhang, X. (2015) · International Conference on Solid-State Sensors, Actuators and Microsystems · doi:10.1109/transducers.2015.7180938
Experimental myocardial regeneration with stem cell therapy
Kaplan, E. (2010) · Radboud Repository (Radboud University)
Cardiac regeneration: effect of nerve growth factor
Lam, N. T. (2017) · Figshare · doi:10.26180/4657594
Heart Failure
Benjamin, I. J. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382227-7.00048-3
Reactive Oxygen Species and Cardiovascular Diseases
Engrcia, V., de Abreu, L. C., Ferreira, C., & Saldiv, P. H. N. (2012) · InTech eBooks · doi:10.5772/32706
Oxidative Stress and Redox Signalling in Cardiac Remodelling
Zhang, M., Sirker, A., & Shah, A. M. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-600-9_21
Einfluss körperlichen Übergewichts auf die Entwicklung einer kardialen Hypertrophie und die kardialen Umbauprozesse nach experimenteller Myokardischämie
Bremen, E. S. (2011) · doi:10.53846/goediss-3547
Signalling pathways in pressure overload‐induced cardiac remodelling: A dynamic entity
Xu, M. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05264.x
Focus Issue: Cell Death in the Heart
Jones, W. K. (2003) · Cardiovascular Toxicology · doi:10.1385/ct:3:3:179
Protection effects of basil on cardiac cells apoptosis after chronic exposure to electromagnetic field (EMF) in rats by TUNEL assay
Khaki, A. A., & Khaki, A. (2012) · International Journal of Biosciences (IJB)
Cardiomyocyte Survival Pathways
Lips, D. J. (2004) · Utrecht University Repository (Utrecht University)
The Transition from Hypertensive Hypertrophy to Left Ventricular Systolic Chamber Decompensation
Veliotes, D. G. A. (2013) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)
Aging and the Frontier Ahead
Marı́n-Garcı́a, J., Goldenthal, M. J., & Moe, G. W. P. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-74072-0_16
Editorial Oxidative Stress and Antioxidant Strategies in Cardiovascular Disease
Belló‐Klein, A., Khaper, N., Llesuy, S., Vassallo, D. V., Pantos, C. I., (oh, H. R., & Peroxide, H. (2016)
Treatment Options Anemia in Chronic Heart Failure : Prevalence, Etiology, Clinical Correlates, and
Tang, Y.-D., & Katz, S. D. (2013)
Am J Physiol Regulatory Integrative Comp Physiol
Sharma, R. V., Davisson, R. L., Lindley, T. E., Infanger, D. W., Rishniw, M., Zhou, Y., & Doobay, M. F. (2009)
The effects of ethanol and acetaldehyde on apoptosis and expression of modulatory genes in heart
Jänkälä, H. (2005) · Työväentutkimus Vuosikirja
Diabetic cardiomyopathy: effects of fatty acids and glucose on adult rat cardiac cells
Dyntar, D. (2003) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-a-004622246
An investigation into the relationships between telomere length and cardiac function and geometry
Raymond, A. R. (2014) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)
Cardiac specific transgenic inhibition of nuclear factor-kappaB (NF-kB) mitigates adverse cardiac remodeling and ameliorates cardiac dysfunction in doxorubicin-induced cardiomyopathy.
Sanganalmath, S. K. (2010) · doi:10.18297/etd/1261

Authors: Wencker, D., Chandra, M., Nguyen, K., Miao, W., Garantziotis, S., Factor, S. M., Shirani, J., Armstrong, R. C., & Kitsis, R. N.
Affiliations: Albert Einstein College of Medicine (US)
Yeshiva University (US)
Pfizer (United States) (US)
Corresponding author: Kitsis, Richard N.
ORCID: Wencker, Detlef
Garantziotis, Stavros
Shirani, Jamshid
Kitsis, Richard N.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2003-05-15
Volume: 111
Issue: 10
Pages: 1497-1504
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci17664
PMC: PMC155051
OpenAlex: W2002958873
Cited by: 765
References: 29
Citations by year: 2026: 12 · 2025: 15 · 2024: 27 · 2023: 18 · 2022: 31 · 2021: 18 · 2020: 31 · 2019: 23 · 2018: 28 · 2017: 32 · 2016: 35 · 2015: 28 · 2014: 45 · 2013: 30 · 2012: 42
FWCI: 32.18
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Ariad Pharmaceuticals
New York Academy of Medicine
National Institutes of Health
National Heart, Lung, and Blood Institute (R01-HL-61550, R01 HL-60665, R01HL061550, R01HL060665)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Keywords: cardiomyocyte apoptosis, heart failure, dilated cardiomyopathy, caspases, transgenic mice, myocardial cell death, contractile dysfunction, heart failure pathogenesis
MeSH terms: Animals, Disease Models, Animal, Enzyme Activation, Heart Failure, Humans, Mice, Inbred C57BL, Mice, Transgenic, Myocardium, Organ Specificity, Recombinant Fusion Proteins, Tacrolimus, Apoptosis, Disease Progression, Transgenes, Dimerization, Caspases, Enzyme Activators, Tacrolimus Binding Proteins, Myocytes, Cardiac, Mice, Caspase 8, Caspase 9

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A mechanistic role for cardiac myocyte apoptosis in heart failure

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks