Apoptosis and heart failure: clinical relevance and therapeutic target
Abstract
Heart failure is the final common pathway of diverse etiologies that are characterized by impaired systolic and/or diastolic function with high morbidity and mortality. An integral part of pathogenesis of heart failure is myocyte loss. The traditional explanation for myocyte loss was cell necrosis but over the last decade, there has been a surge of evidence affirming the role of apoptosis in genesis of heart failure. Studies have raised apoptosis from a 'histologic curiosity' to an exciting 'clinical target' that can be modulated to attenuate the progression of heart failure. This review will focus on the clinical relevance of apoptosis in human and experimental heart failure and identify some of the progress made in myocardial anti-apoptotic intervention.
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Myocyte apoptosis has been suggested to be an important etiological component of heart failure, particularly in the transition from compensatory remodeling to heart failure, although this concept has been somewhat contentious.
“Myocyte apoptosis has been suggested to be an important etiological component of heart failure, particularly in the transition from compensatory remodeling to heart failure (112), although this concept has been somewhat contentious (95, 189, 295, 301).”
From Cardiac remodeling in obesity (2008) · cites this paper as [112]
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- Authors
- GARG, S., NARULA, J., & CHANDRASHEKHAR, Y.
- Affiliations
- Drexel University (US)
- University of California, Irvine Medical Center (US)
- University of Minnesota (US)
- Venue
- Journal of Molecular and Cellular Cardiology
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 38
- Issue
- 1
- Pages
- 73-79
- ISSN
- 0022-2828 (ISSN-L)
- OpenAlex
- W2110058514
- Cited by
- 103
- References
- 77
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 6 · 2016: 5 · 2015: 3 · 2014: 8 · 2013: 3 · 2012: 7
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular and Cellular Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- apoptosis, heart failure, cardiomyocyte loss, myocardial necrosis, anti-apoptotic therapy, heart failure pathogenesis, systolic dysfunction, diastolic dysfunction, therapeutic target
- MeSH terms
- Animals, Humans, Cardiomyopathies, Myocardial Reperfusion Injury, Apoptosis, Disease Progression
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