The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
Open accessAbstract
The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in the regulation of food intake. Here we show that the lack of CB1 in mice with a disrupted CB1 gene causes hypophagia and leanness. As compared with WT (CB1+/+) littermates, mice lacking CB1 (CB1-/-) exhibited reduced spontaneous caloric intake and, as a consequence of reduced total fat mass, decreased body weight. In young CB1-/- mice, the lean phenotype is predominantly caused by decreased caloric intake, whereas in adult CB1-/- mice, metabolic factors appear to contribute to the lean phenotype. No significant differences between genotypes were detected regarding locomotor activity, body temperature, or energy expenditure. Hypothalamic CB1 mRNA was found to be coexpressed with neuropeptides known to modulate food intake, such as corticotropin-releasing hormone (CRH), cocaine-amphetamine-regulated transcript (CART), melanin-concentrating hormone (MCH), and preproorexin, indicating a possible role for endocannabinoid receptors within central networks governing appetite. CB1-/- mice showed significantly increased CRH mRNA levels in the paraventricular nucleus and reduced CART mRNA levels in the dorsomedial and lateral hypothalamic areas. CB1 was also detected in epidydimal mouse adipocytes, and CB1-specific activation enhanced lipogenesis in primary adipocyte cultures. Our results indicate that the cannabinoid system is an essential endogenous regulator of energy homeostasis via central orexigenic as well as peripheral lipogenic mechanisms and might therefore represent a promising target to treat diseases characterized by impaired energy balance.
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Cites
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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
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“CART mRNA was abundantly expressed in the hypothalamus, especially in the supraoptic nucleus, PVN, VMN, dorsomedial nucleus (DMN), LHA, and ARC (30), whereas the expression of prepro-orexin and MCH mRNAs was restricted to the neurons localized in LHA and in the zona incerta (31, 32).”
BackgroundEffects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency
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Self-citationBrain monoglyceride lipase participating in endocannabinoid inactivation
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The Endocannabinoid System as an Emerging Target of Pharmacotherapy
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The orphan receptor GPR55 is a novel cannabinoid receptor
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Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
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The Human Obesity Gene Map: The 2005 Update
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The endocannabinoid system and its therapeutic exploitation
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Metadata
- Authors
- Cota, D., Marsicano, G., Tschöp, M., Grübler, Y., Flachskamm, C., Schubert, M., Auer, D., Yassouridis, A., Thöne-Reineke, C., Ortmann, S., Tomassoni, F., Cervino, C., Nisoli, E., Linthorst, A. C. E., Pasquali, R., Lutz, B., Stalla, G. K., & Pagotto, U.
- Venue
- Journal of Clinical Investigation
- Published
- 2003-08-01
- Volume
- 112
- Issue
- 3
- Pages
- 423-431
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2073734463
- Cited by
- 1,168
- References
- 6
- FWCI
- 40.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cota, D., Marsicano, G., Tschöp, M., Grübler, Y., Flachskamm, C., Schubert, M., Auer, D., Yassouridis, A., Thöne-Reineke, C., Ortmann, S., Tomassoni, F., Cervino, C., Nisoli, E., Linthorst, A. C. E., Pasquali, R., Lutz, B., Stalla, G. K., & Pagotto, U. (2003). The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. Journal of Clinical Investigation. https://doi.org/10.1172/jci17725
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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