Cited by 1,119Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and AnimalsRegulation of Appetite and Obesity

The Human Obesity Gene Map: The 2005 Update

Rankinen, Tuomo, Zuberi, Aamir, Chagnon, Yvon C., Weisnagel, S. John, Argyropoulos, George, Walts, Brandon, Pérusse, Louis, Bouchard, Claude·2006·Obesity

Abstract

This paper presents the 12th update of the human obesity gene map, which incorporates published results up to the end of October 2005. Evidence from single‐gene mutation obesity cases, Mendelian disorders exhibiting obesity as a clinical feature, transgenic and knockout murine models relevant to obesity, quantitative trait loci (QTL) from animal cross‐breeding experiments, association studies with candidate genes, and linkages from genome scans is reviewed. As of October 2005, 176 human obesity cases due to single‐gene mutations in 11 different genes have been reported, 50 loci related to Mendelian syndromes relevant to human obesity have been mapped to a genomic region, and causal genes or strong candidates have been identified for most of these syndromes. There are 244 genes that, when mutated or expressed as transgenes in the mouse, result in phenotypes that affect body weight and adiposity. The number of QTLs reported from animal models currently reaches 408. The number of human obesity QTLs derived from genome scans continues to grow, and we now have 253 QTLs for obesity‐related phenotypes from 61 genome‐wide scans. A total of 52 genomic regions harbor QTLs supported by two or more studies. The number of studies reporting associations between DNA sequence variation in specific genes and obesity phenotypes has also increased considerably, with 426 findings of positive associations with 127 candidate genes. A promising observation is that 22 genes are each supported by at least five positive studies. The obesity gene map shows putative loci on all chromosomes except Y. The electronic version of the map with links to useful publications and relevant sites can be found at http:obesitygene.pbrc.edu

Integrity signals

Registry

Crossref · 10.1038/oby.2006.71

Cites

1346 of 1346 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Among the approximately 20 major genes linked to obesity development, none are directly implicated in known reward function mechanisms.

    “Among the 20 or so major genes (clear evidence from at least two independent studies) linked to the development of obesity ([129](#B129)), none are directly implicated in known mechanisms of reward functions.”

    From Food reward, hyperphagia, and obesity (2011) · cites this paper as [129]

  • The combined effect of the major genes linked to obesity accounts for less than about 5% of human obesity.

    “However, because the combined effect of these genes only accounts for less than ∼5% of human obesity, it is very likely that many important genes have not yet been discovered, some of which could operate within the reward system.”

    From Food reward, hyperphagia, and obesity (2011) · cites this paper as [129]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Rankinen, T., Zuberi, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Pérusse, L., & Bouchard, C.
Affiliations
  • Pennington Biomedical Research Center (US)
  • Université Laval (CA)
Corresponding author
Bouchard, Claude
Venue
Obesity
Publisher
Wiley
Published
2006-04
Volume
14
Issue
4
Pages
529-644
ISSN
  • 1930-7381 (ISSN-L)
  • 1930-739X
OpenAlex
W2134511980
Cited by
1,119
References
1,346
Citations by year
2026: 5 · 2025: 6 · 2024: 18 · 2023: 13 · 2022: 18 · 2021: 26 · 2020: 23 · 2019: 34 · 2018: 29 · 2017: 38 · 2016: 45 · 2015: 62 · 2014: 65 · 2013: 79 · 2012: 99
FWCI
13.17
Type
journal article
Language
en
Open access
closed
Locations
  • Obesity (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
genetic susceptibility, transgenic mouse model, knockout mouse models, quantitative trait loci, genome scan, candidate genes, genetic association studies, body weight, adiposity
MeSH terms
Animals, Chromosome Mapping, Chromosomes, Human, Humans, Genetic Linkage, Mice, Transgenic, Obesity, Mice, Knockout, Quantitative Trait Loci, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review