The Human Obesity Gene Map: The 2005 Update
Abstract
This paper presents the 12th update of the human obesity gene map, which incorporates published results up to the end of October 2005. Evidence from single‐gene mutation obesity cases, Mendelian disorders exhibiting obesity as a clinical feature, transgenic and knockout murine models relevant to obesity, quantitative trait loci (QTL) from animal cross‐breeding experiments, association studies with candidate genes, and linkages from genome scans is reviewed. As of October 2005, 176 human obesity cases due to single‐gene mutations in 11 different genes have been reported, 50 loci related to Mendelian syndromes relevant to human obesity have been mapped to a genomic region, and causal genes or strong candidates have been identified for most of these syndromes. There are 244 genes that, when mutated or expressed as transgenes in the mouse, result in phenotypes that affect body weight and adiposity. The number of QTLs reported from animal models currently reaches 408. The number of human obesity QTLs derived from genome scans continues to grow, and we now have 253 QTLs for obesity‐related phenotypes from 61 genome‐wide scans. A total of 52 genomic regions harbor QTLs supported by two or more studies. The number of studies reporting associations between DNA sequence variation in specific genes and obesity phenotypes has also increased considerably, with 426 findings of positive associations with 127 candidate genes. A promising observation is that 22 genes are each supported by at least five positive studies. The obesity gene map shows putative loci on all chromosomes except Y. The electronic version of the map with links to useful publications and relevant sites can be found at http:obesitygene.pbrc.edu
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Among the approximately 20 major genes linked to obesity development, none are directly implicated in known reward function mechanisms.
“Among the 20 or so major genes (clear evidence from at least two independent studies) linked to the development of obesity ([129](#B129)), none are directly implicated in known mechanisms of reward functions.”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [129]
The combined effect of the major genes linked to obesity accounts for less than about 5% of human obesity.
“However, because the combined effect of these genes only accounts for less than ∼5% of human obesity, it is very likely that many important genes have not yet been discovered, some of which could operate within the reward system.”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [129]
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- Authors
- Rankinen, T., Zuberi, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Pérusse, L., & Bouchard, C.
- Affiliations
- Pennington Biomedical Research Center (US)
- Université Laval (CA)
- Corresponding author
- Bouchard, Claude
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2006-04
- Volume
- 14
- Issue
- 4
- Pages
- 529-644
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2134511980
- Cited by
- 1,119
- References
- 1,346
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 18 · 2023: 13 · 2022: 18 · 2021: 26 · 2020: 23 · 2019: 34 · 2018: 29 · 2017: 38 · 2016: 45 · 2015: 62 · 2014: 65 · 2013: 79 · 2012: 99
- FWCI
- 13.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- genetic susceptibility, transgenic mouse model, knockout mouse models, quantitative trait loci, genome scan, candidate genes, genetic association studies, body weight, adiposity
- MeSH terms
- Animals, Chromosome Mapping, Chromosomes, Human, Humans, Genetic Linkage, Mice, Transgenic, Obesity, Mice, Knockout, Quantitative Trait Loci, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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