The DOI matches its OpenAlex record; 5 of the 5 references it cites were found in a registry or an index.
The enigma of sepsis
Open accessAbstract
Sepsis remains a serious cause of morbidity and mortality, and the pathophysiology of the disease is not clear. The definition of the clinical manifestations of sepsis is ever evolving. This review discusses the search for effective therapeutic interventions, hurdles in translational sepsis research, and new therapies in development in current clinical trials.
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Citations
Cites
Early goal-directed therapy in the treatment of severe sepsis and septic shock
Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743
The epidemiology of sepsis in the United States from 1979 through 2000
Martin, G. S., Mannino, D. M., Eaton, S., & Moss, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022139 · Cited by 5,841
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448 · cited 1×
“found that TNF-α blockade was beneficial in animal models of shock following infusion of endotoxin or Escherichia coli (17, 18).”
Detection of circulating tumor necrosis factor after endotoxin administration
Michie, H. R., Manogue, K. R., Spriggs, D. R., Revhaug, A., O'Dwyer, S., Dinarello, C. A., Cerami, A., Wolff, S. M., & Wilmore, D. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806093182301 · Cited by 1,677 · cited 1×
“462 The Journal of Clinical Investigation | August 2003 | Volume 112 | Number 4 characteristic of sepsis (14), while passive immunization with anti–TNF-αwas protective (15, 16).”
Cited by
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs
Rhen, T., & Cidlowski, J. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050541 · Cited by 3,149
Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis
Gonzalez-Rey, E., Anderson, P., González, M. A., Rico, L., Büscher, D., & Delgado, M. (2009) · Gut · doi:10.1136/gut.2008.168534 · Cited by 677
Becker, K. L., Nylén, E. S., White, J. C., Müller, B., & Snider, R. H. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021444 · Cited by 578
Neuromuscular manifestations of critical illness
Bolton, C. F. (2005) · Muscle & Nerve · doi:10.1002/mus.20304 · Cited by 411
MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock
Zhao, Q., Wang, X., Nelin, L. D., Yao, Y., Matta, R., Manson, M. E., Baliga, R. S., Meng, X., Smith, C. V., Bauer, J. A., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051794 · Cited by 370
Metadata
- Authors
- Riedemann, N. C., Guo, R., & Ward, P. A.
- Venue
- Journal of Clinical Investigation
- Publisher
- American Society for Clinical Investigation
- Published
- 2003-08-15
- Volume
- 112
- Issue
- 4
- Pages
- 460-467
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1976455881
- Cited by
- 624
- References
- 5
- FWCI
- 26.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The enigma of sepsis. https://app.cochat.ai/papers/10.1172/jci19523
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- Riedemann, N. C., Guo, R., & Ward, P. A. (2003). The enigma of sepsis. Journal of Clinical Investigation. https://doi.org/10.1172/jci19523
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
