The DOI matches its OpenAlex record; 1 of the 1 references it cites were found in a registry or an index.
Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections
Open accessAbstract
Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. The discovery of bacterial-communication systems (quorum-sensing systems), which orchestrate important temporal events during the infection process, has afforded a novel opportunity to ameliorate bacterial infection by means other than growth inhibition. Compounds able to override bacterial signaling are present in nature. Herein we discuss the known signaling mechanisms and potential antipathogenic drugs that specifically target quorum-sensing systems in a manner unlikely to pose a selective pressure for the development of resistant mutants.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., & Greenberg, E. P. (1998) · Science · doi:10.1126/science.280.5361.295 · Cited by 3,396
Cited by
THE ROLE OF ROOT EXUDATES IN RHIZOSPHERE INTERACTIONS WITH PLANTS AND OTHER ORGANISMS
Bais, H. P., Weir, T. L., Perry, L. G., Gilroy, S., & Vivanco, J. M. (2006) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.57.032905.105159 · Cited by 4,682
Effect of essential oils on pathogenic bacteria
Nazzaro, F., Fratianni, F., De Martino, L., Coppola, R., & De Feo, V. (2013) · Pharmaceuticals · doi:10.3390/ph6121451 · Cited by 2,186
“Researchers are increasingly investigating herbal products in the quest for new therapeutic and anti-pathogenic agents that might act as nontoxic inhibitors of QS, thus controlling infections without encouraging the appearance of resistant bacterial strains [122].”
BackgroundBrackman, G., Defoirdt, T., Miyamoto, C., Bossier, P., Van Calenbergh, S., Nelis, H., & Coenye, T. (2008) · BMC Microbiology · doi:10.1186/1471-2180-8-149 · Cited by 317
Khan, M. S. A., Zahin, M., Hasan, S., Husain, F. M., & Ahmad, I. (2009) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2009.02666.x · Cited by 279
The Battle of Probiotics and Their Derivatives Against Biofilms
Barzegari, A., Kheyrolahzadeh, K., Hosseiniyan Khatibi, S. M., Sharifi, S., Memar, M. Y., & Zununi Vahed, S. (2020) · Infection and Drug Resistance · doi:10.2147/idr.s232982 · Cited by 263
Metadata
- Authors
- Hentzer, M., & Givskov, M.
- Venue
- Journal of Clinical Investigation
- Publisher
- American Society for Clinical Investigation
- Published
- 2003-11-01
- Volume
- 112
- Issue
- 9
- Pages
- 1300-1307
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2118023881
- Cited by
- 739
- References
- 1
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections. https://app.cochat.ai/papers/10.1172/jci200320074
- The paper
- Hentzer, M., & Givskov, M. (2003). Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections. Journal of Clinical Investigation. https://doi.org/10.1172/jci200320074
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
