The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Fat’s loss is bone’s gain
Open accessAbstract
Osteoporosis, characterized by low bone mass and structural deterioration of bone tissue with an increased susceptibility to fractures, is a major public health threat to the elderly. Bone mass homeostasis in adults is maintained locally by the balance between osteoblastic bone formation and osteoclastic bone resorption. Haploinsufficiency of PPARgamma, a key transcription factor implicated previously in adipogenesis, lipid metabolism, and glucose homeostasis, has now been shown to promote osteogenesis through enhanced osteoblast formation. These findings support a reciprocal relationship between the development of bone and fat, and may prompt further exploration of the PPAR pathway as a potential target for intervention in osteoporosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · cited 1×
“Despite the incorporation of powerful multifactorial nomograms into our decision process, the ability to predict individual patient outcome remains limited (2, 3).”
Background
Cited by
Atashi, F., Modarressi, A., & Pepper, M. S. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0484 · Cited by 603
BMI and BMD: the potential interplay between obesity and bone fragility
Palermo, A., Tuccinardi, D., Defeudis, G., Watanabe, M., D’Onofrio, L., Lauria Pantano, A., Napoli, N., Pozzilli, P., & Manfrini, S. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13060544 · Cited by 197
Soltani, S., Hunter, G. R., Kazemi, A., & Shab-Bidar, S. (2016) · Osteoporosis International · doi:10.1007/s00198-016-3617-4 · Cited by 89
Semirale, A. A., Zhang, X., & Wiren, K. M. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23098 · Cited by 42
“It has been suggested that MSC precursors differentiate into adipose rather than bone with a reciprocal relationship [Pei and Tontonoz, 2004], and thus may contribute to age-related body composition changes.”
BackgroundWiren, K. M., Hashimoto, J. G., & Zhang, X.-W. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23288 · Cited by 5
Metadata
- Authors
- Pei, L., & Tontonoz, P.
- Venue
- Journal of Clinical Investigation
- Published
- 2004-03-15
- Volume
- 113
- Issue
- 6
- Pages
- 805-806
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2075452212
- Cited by
- 181
- References
- 1
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Fat’s loss is bone’s gain. https://app.cochat.ai/papers/10.1172/jci200421311
- The paper
- Pei, L., & Tontonoz, P. (2004). Fat’s loss is bone’s gain. Journal of Clinical Investigation. https://doi.org/10.1172/jci200421311
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
