Body composition changes and inhibition of fat development in vivo implicates androgen in regulation of stem cell lineage allocation
Open accessAbstract
Androgens regulate body composition in youth and declining testosterone that occurs with aging is associated with muscle wasting, increased fat mass and osteopenia. Transgenic mice with targeted androgen receptor (AR) over‐expression in mesenchymal stem cells (MSC) were generated to explore the role of androgen signaling in the regulation of body composition. Transgenic males, but not females, were shorter and have reduced body weight and visceral fat accumulation. Dual‐energy X‐ray absorptiometry (DXA) revealed significant reductions in fat mass with a reciprocal increase in lean mass, yet no difference in food consumption or locomotor activity was observed. Adipose tissue weight was normal in brown fat but reduced in both gonadal and perirenal depots, and reduced hyperplasia was observed with smaller adipocyte size in visceral and subcutaneous white adipose tissue. Although serum leptin, adiponectin, triglyceride, and insulin levels were no different between the genotypes, intraperitoneal glucose tolerance testing (IPGTT) showed improved glucose clearance in transgenic males. High levels of the AR transgene are detected in MSCs but not in mature fat tissue. Reduced fibroblast colony forming units indicate fewer progenitor cells resident in the marrow in vivo. Precocious expression of glucose transporter 4 (GLUT4), peroxisome proliferator‐activated receptor γ (PPARγ), and CCAAT enhancer‐binding protein α (C/EBPα) was observed in proliferating precursor cultures from transgenic mice compared to controls. In more mature cultures, there was little difference between the genotypes. We propose a mechanism where enhanced androgen sensitivity can alter lineage commitment in vivo to reduce progenitor number and fat development, while increasing the expression of key factors to promote smaller adipocytes with improved glucose clearance. J. Cell. Biochem. 112: 1773–1786, 2011. © 2011 Wiley‐Liss, Inc.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Male Col3.6AR-Tg mice displayed reduced visceral fat mass in the gonadal and peri-renal fat depots and smaller adipocyte area in the absence of any changes in serum adipokines.
“Male Col3.6AR‐Tg mice displayed reduced visceral fat mass in the gonadal and peri‐renal fat depots and smaller adipocyte area in the absence of any changes in serum adipokines.”
From The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments (2022) · cites this paper as [166]
More recent evidence discussed in this review suggests that androgen action via the AR in BMPCs decreases fat mass.
“In addition, more recent evidence discussed in this review suggests that androgen action via the AR in BMPCs decreases fat mass, 126 , 166 , 189 is an exciting avenue of research.”
From The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments (2022) · cites this paper as [166]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326 · see citing works
Winer, J., Jung, C. K. S., Shackel, I., & Williams, P. M. (1999) · Analytical Biochemistry · doi:10.1006/abio.1999.4085 · Cited by 1,388 · see citing works
Identification of White Adipocyte Progenitor Cells In Vivo
Rodeheffer, M. S., Birsoy, K., & Friedman, J. M. (2008) · Cell · doi:10.1016/j.cell.2008.09.036 · Cited by 945 · see citing works
Effects of Androgenic-Anabolic Steroids in Athletes
Hartgens, F., & Kuipers, H. (2004) · Sports Medicine · doi:10.2165/00007256-200434080-00003 · Cited by 878 · see citing works
New developments in adipogenesis
Lefterova, M. I., & Lazar, M. A. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.11.005 · Cited by 861 · see citing works
Moerman, E., Teng, K., Lipschitz, D., & Lecka-Czernik, B. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00127.x · Cited by 840 · see citing works
Weyer, C., Foley, J. E., Bogardus, C., Tataranni, P. A., & Pratley, R. E. (2000) · Diabetologia · doi:10.1007/s001250051560 · Cited by 799 · see citing works
Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth
Jo, J., Gavrilova, O., Pack, S., Jou, W., Mullen, S., Sumner, A. E., Cushman, S. W., & Periwal, V. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000324 · Cited by 776 · see citing works
Yeh, S., Tsai, M.-Y., Xu, Q., Mu, X., Lardy, H. A., Huang, K., Lin, H., Yeh, S.-D., Altuwaijri, S., Zhou, X., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212474399 · Cited by 668 · see citing works
Wang, C., Cunningham, G., Dobs, A., Iranmanesh, A., Matsumoto, A. M., Snyder, P. J., Weber, T., Berman, N., Hull, L., & Swerdloff, R. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032006 · Cited by 656 · see citing works
Seidell, J. C., Björntorp, P., Sjöström, L., Kvist, H., & Sannerstedt, R. (1990) · Metabolism · doi:10.1016/0026-0495(90)90297-p · Cited by 567 · see citing works
Singh, R., Artaza, J. N., Taylor, W. E., Gonzalez-Cadavid, N. F., & Bhasin, S. (2003) · Endocrinology · doi:10.1210/en.2003-0741 · Cited by 555 · see citing works
Andropause: clinical implications of the decline in serum testosterone levels with aging in men
Matsumoto, A. M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.2.m76 · Cited by 490 · see citing works
Mauras, N., Hayes, V. Y., Welch, S., Rini, A., Helgeson, K., Dokler, M. L., Veldhuis, J. D., & Urban, R. J. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4892 · Cited by 409 · see citing works
The benefits and risks of testosterone replacement therapy: a review
Morley, J. E. (2009) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s3025 · Cited by 375 · see citing works
Singh, R., Artaza, J. N., Taylor, W. E., Braga, M., Yuan, X., Gonzalez-Cadavid, N. F., & Bhasin, S. (2006) · Endocrinology · doi:10.1210/en.2004-1649 · Cited by 369 · see citing works
Garza, L. A., Yang, C., Zhao, T., Blatt, H. B., Lee, M. S., He, H., Stanton, D. C., Carrasco, L., Spiegel, J. H., Tobias, J. W., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44478 · Cited by 330 · see citing works
The Human Obesity Gene Map: The 2003 Update
Snyder, E. E., Walts, B., Përusse, L., Chagnon, Y. C., Weisnagel, S. J., Rankinen, T., & Bouchard, C. (2004) · Obesity Research · doi:10.1038/oby.2004.47 · Cited by 316 · see citing works
Fan, W., Yanase, T., Nomura, M., Okabe, T., Goto, K., Sato, T., Kawano, H., Kato, S., & Nawata, H. (2005) · Diabetes · doi:10.2337/diabetes.54.4.1000 · Cited by 269 · see citing works
Crossno, J. T., Majka, S. M., Grazia, T. J., Gill, R. G., & Klemm, D. J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28510 · Cited by 268 · see citing works
Roberts, R., Hodson, L., Dennis, A., Neville, M. J., Humphreys, S. M., Harnden, K., Micklem, K., & Frayn, K. N. (2009) · Diabetologia · doi:10.1007/s00125-009-1300-4 · Cited by 263 · see citing works
Storer, T. W., Magliano, L., Woodhouse, L. J., Lee, M. L., Dzekov, C., Dzekov, J., Casaburi, R. H., & Bhasin, S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021231 · Cited by 248 · see citing works
Bhasin, S., Taylor, W. E., Singh, R., Artaza, J., Sinha-Hikim, I., Jasuja, R., Choi, H., & Gonzalez-Cadavid, N. F. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.12.m1103 · Cited by 215 · see citing works
MacLean, H. E., Chiu, W. S. M., Notini, A. J., Axell, A.-M., Davey, R. A., McManus, J. F., Ma, C., Plant, D. R., Lynch, G. S., & Zajac, J. D. (2008) · The FASEB Journal · doi:10.1096/fj.08-105726 · Cited by 209 · see citing works
Adipocyte size predicts incidence of type 2 diabetes in women
Lönn, M., Mehlig, K., Bengtsson, C., & Lissner, L. (2009) · The FASEB Journal · doi:10.1096/fj.09-133058 · Cited by 203 · see citing works
Dieudonné, M., Pecquery, R., Boumédiène, A., Leneveu, M.-C., & Giudicelli, Y. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.6.c1645 · Cited by 197 · see citing works
Late onset of obesity in male androgen receptor-deficient (AR KO) mice
Sato, T., Μatsumoto, T., Yamada, T., Watanabe, T., Kawano, H., & Kato, S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02774-2 · Cited by 196 · see citing works
Pei, L., & Tontonoz, P. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21311 · Cited by 181 · see citing works
Insulin and Leptin Resistance With Hyperleptinemia in Mice Lacking Androgen Receptor
Lin, H., Xu, Q., Yeh, S., Wang, R.-S., Sparks, J. D., & Chang, C. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1717 · Cited by 172 · see citing works
Bianco, P., Kuznetsov, S. A., Riminucci, M., & Robey, P. G. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)19006-0 · Cited by 169 · see citing works
Effect of testosterone on lipolysis in human pre-adipocytes from different fat depots
Dicker, A., Rydén, M., Näslund, E. B., Muehlen, I. E., Wirén, M., Lafontan, M., & Arner, P. (2004) · Diabetologia · doi:10.1007/s00125-003-1324-0 · Cited by 163 · see citing works
Gupta, V., Bhasin, S., Guo, W., Singh, R., Miki, R., Chauhan, P., Choong, K., Tchkonia, T., Lebrasseur, N. K., Flanagan, J. N., et al. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.08.019 · Cited by 162 · see citing works
Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men.
Woodhouse, L., Gupta, N., Bhasin, M., Singh, A. B., Ross, R., Phillips, J., & Bhasin, S. (2004) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2003-031492 · Cited by 159 · see citing works
Kalajzic, Z., Liu, P., Kalajzić, I., Du, Z., Braut, A., Mina, M., CANALIS, E. M., & Rowe, D. W. (2002) · Bone · doi:10.1016/s8756-3282(02)00912-2 · Cited by 144 · see citing works
Callewaert, F., Venken, K., Ophoff, J., Gendt, K. D., Torcasio, A., van Lenthe, H., Oosterwyck, H. V., Boonen, S., Bouillon, R., Verhoeven, G., et al. (2008) · The FASEB Journal · doi:10.1096/fj.08-113456 · Cited by 142 · see citing works
Ophoff, J., Proeyen, K. V., Callewaert, F., Gendt, K. D., Bock, K. D., Bosch, A. V., Verhoeven, G., Hespel, P., & Vanderschueren, D. (2009) · Endocrinology · doi:10.1210/en.2008-1509 · Cited by 123 · see citing works
Hashimoto, J. G., Beadles-Bohling, A. S., & Wiren, K. M. (2004) · BioTechniques · doi:10.2144/04361bm06 · Cited by 113 · see citing works
Self-citationDevelopmental origin of adipocytes: new insights into a pending question
Billon, N., Monteiro, M. C., & Dani, C. (2008) · Biology of the Cell · doi:10.1042/bc20080011 · Cited by 109 · see citing works
Rodríguez‐Cuenca, S., Monjo, M., Proenza, A. M., & Roca, P. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00270.2004 · Cited by 97 · see citing works
Wiren, K. M., Toombs, A. R., Semirale, A. A., & Zhang, X. (2006) · Bone · doi:10.1016/j.bone.2005.10.029 · Cited by 87 · see citing works
Self-citationWiren, K. M., Zhang, X.-W., Toombs, A. R., Kasparcova, V., Gentile, M. A., Harada, S.-I., & Jepsen, K. J. (2004) · Endocrinology · doi:10.1210/en.2003-1016 · Cited by 80 · see citing works
Self-citationHyperleptinemia without Obesity in Male Mice Lacking Androgen Receptor in Adipose Tissue
Yu, I.-C. I., Lin, H., Liu, N.-C., Wang, R.-S., Sparks, J. D., Yeh, S., & Chang, C. (2008) · Endocrinology · doi:10.1210/en.2007-0516 · Cited by 80 · see citing works
Fat Cell Size, Insulin Sensitivity, and Inflammation in Obese Children
Maffeis, C., Silvagni, D., Bonadonna, R. C., Grezzani, A., Banzato, C., & Tatò, L. (2007) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.04.053 · Cited by 73 · see citing works
Myocyte Androgen Receptors Increase Metabolic Rate and Improve Body Composition by Reducing Fat Mass
Fernando, S. M., Rao, P., Niel, L., Chatterjee, D., Stagljar, M., & Monks, D. A. (2010) · Endocrinology · doi:10.1210/en.2010-0018 · Cited by 69 · see citing works
Eckertova, M., Ondrejcakova, M., Krskova, K., Zorad, S., & Jezova, D. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01037.x · Cited by 68 · see citing works
Wiren, K. M., Semirale, A. A., Zhang, X.-W., Woo, A., Tommasini, S. M., Price, C., Schaffler, M. B., & Jepsen, K. J. (2008) · Bone · doi:10.1016/j.bone.2008.04.026 · Cited by 65 · see citing works
Self-citationRegulation of body composition by androgens
Bhasin, S. (2003) · Journal of Endocrinological Investigation · doi:10.1007/bf03345230 · Cited by 62 · see citing works
Body fat distribution, adipocyte size, and metabolic characteristics of nondiabetic adults.
Mundi, M., Karpyak, M. V., Koutsari, C., Votruba, S., O'Brien, P., & Jensen, M. (2010) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2009-1353 · Cited by 51 · see citing works
Minoura, H., Takeshita, S., Kimura, C., Hirosumi, J., Takakura, S., Kawamura, I., Seki, J., Manda, T., & Mutoh, S. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00619.x · Cited by 36 · see citing works
Signaling pathways implicated in androgen regulation of endocortical bone
Wiren, K. M., Semirale, A. A., Hashimoto, J. G., & Zhang, X. W. (2009) · Bone · doi:10.1016/j.bone.2009.10.039 · Cited by 26 · see citing works
Self-citationRepin1 maybe involved in the regulation of cell size and glucose transport in adipocytes
Ruschke, K., Illés, M., Kern, M., Klöting, I., Faßhauer, M., Schön, M. R., Kosacka, J., Fitzl, G., Kovacs, P. L., Stümvoll, M., et al. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.08.049 · Cited by 22 · see citing works
Du, J., Zhang, L., & Wang, Z. (2009) · PubMed · Cited by 17 · see citing works
Flagged first, then by citations
2 of the 54 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Transcriptional Regulation of Adipogenesis
de Sá, P. M., Richard, A. J., Hang, H., & Stephens, J. M. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160022 · Cited by 395 · see citing works
Sarjeant, K., & Stephens, J. M. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008417 · Cited by 328 · see citing works
Lowered testosterone in male obesity: Mechanisms, morbidity and management
Grossmann, M., Tang Fui, M., & Dupuis, P. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.122365 · Cited by 293 · see citing works
Dubois, V., Laurent, M., Boonen, S., Vanderschueren, D., & Claessens, F. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0883-3 · Cited by 197 · see citing works
Androgens inhibit adipogenesis during human adipose stem cell commitment to preadipocyte formation
Chazenbalk, G. D., Singh, P., Irge, D., Shah, A., Abbott, D. H., & Dumesic, D. A. (2013) · Steroids · doi:10.1016/j.steroids.2013.05.001 · Cited by 167 · see citing works
Chen, J., Lin, P., Tsai, Y.-R., Yang, Y.-C., & Kang, H. (2019) · Cells · doi:10.3390/cells8111318 · Cited by 122 · see citing works
Adipocytes in Skin Health and DiseasePreprint
Rivera-Gonzalez, G. C., Shook, B., & Horsley, V. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015271 · Cited by 111 · see citing works
Yu, I.-C. I., Lin, H., Sparks, J. D., Yeh, S., & Chang, C. (2014) · Diabetes · doi:10.2337/db13-1505 · Cited by 71 · see citing works
The Aging Overactive Bladder: a Review of Aging-Related Changes from the Brain to the Bladder
Suskind, A. M. (2017) · Current Bladder Dysfunction Reports · doi:10.1007/s11884-017-0406-7 · Cited by 70 · see citing works
Traish, A. M., & Zitzmann, M. (2015) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-015-9323-2 · Cited by 57 · see citing works
Gentil, P., de Lira, C. A. B., Paoli, A., dos Santos, J. A. B., da Silva, R. D. T., Pereira, J. R., da Silva, E. P., & Magosso, R. F. (2017) · European Journal of Translational Myology · doi:10.4081/ejtm.2017.6247 · Cited by 58 · see citing works
Transcriptional Regulation of Adipogenesis
de Sá, P. M., Richard, A. J., Hang, H., & Stephens, J. M. (2017) · Comprehensive physiology · doi:10.1002/j.2040-4603.2017.tb00753.x · Cited by 54 · see citing works
Tyagi, P., Tyagi, V., Qu, X., Lin, H.-T., Kuo, H., Chuang, Y., & Chancellor, M. B. (2013) · International Urology and Nephrology · doi:10.1007/s11255-013-0621-x · Cited by 51 · see citing works
Lim, S., Jang, H., Park, E. H., Kim, J. K., Kim, J., Kim, E., Yea, K., Kim, Y. H., Lee‐Kwon, W., Ryu, S. H., et al. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24220 · Cited by 51 · see citing works
Huang, C., Luo, J., Lee, S. O., & Chang, C. (2014) · Stem Cells · doi:10.1002/stem.1722 · Cited by 50 · see citing works
Effect of Panax notoginseng Saponins and Major Anti-Obesity Components on Weight Loss
Zhang, X., Zhang, B., Zhang, C., Sun, G., & Sun, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.601751 · Cited by 49 · see citing works
Self-citationWiren, K. M., Zhang, X.-W., Olson, D. A., Turner, R. T., & Iwaniec, U. T. (2012) · Bone · doi:10.1016/j.bone.2012.08.111 · Cited by 47 · see citing works
Self-citationAbles, E. T., Laws, K. M., & Drummond‐Barbosa, D. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.48 · Cited by 46 · see citing works
Hormonal Regulation of Adipogenesis
Lee, M. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160047 · Cited by 42 · see citing works
Parlee, S. D., Simon, B. R., Scheller, E. L., Alejandro, E. U., Learman, B. S., Krishnan, V., Bernal‐Mizrachi, E., & MacDougald, O. A. (2014) · Endocrinology · doi:10.1210/en.2013-1995 · Cited by 32 · see citing works
Mouse models of peripheral metabolic disease
Xavier, G. D. S., & Hodson, D. J. (2018) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2018.03.009 · Cited by 26 · see citing works
Sakai, H., Uno, H., Yamakawa, H., Tanaka, K. Y., Ikedo, A., Uezumi, A., Ohkawa, Y., & Imai, Y. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2407768121 · Cited by 24 · see citing works
Wiren, K. M., Hashimoto, J. G., Semirale, A. A., & Zhang, X.-W. (2011) · Bone · doi:10.1016/j.bone.2011.06.010 · Cited by 22 · see citing works
Self-citationVenkatesh, V. S., Grossmann, M., Zajac, J. D., & Davey, R. A. (2022) · Obesity Reviews · doi:10.1111/obr.13429 · Cited by 22 · see citing works
Fürst, R. W., Flöter, V. L., Kliem, H., Skurk, T., Hauner, H., Meyer, H. H. D., & Ulbrich, S. E. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.07.006 · Cited by 19 · see citing works
Wang, Y., Chen, H., Li, Y., Hao, H., Liu, J., Chen, Y., Meng, J., Zhang, S., Gu, W., Lyu, Z., et al. (2024) · Cytotherapy · doi:10.1016/j.jcyt.2023.12.006 · Cited by 12 · see citing works
Sexual dimorphism through androgen signaling; from external genitalia to muscles
Ipulan, L. A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.940229 · Cited by 11 · see citing works
Cell-specific functions of androgen receptor in skeletal muscles
Sakai, H., & Imai, Y. (2024) · Endocrine Journal · doi:10.1507/endocrj.ej23-0691 · Cited by 10 · see citing works
The Androgen Receptor Bridges Stem Cell‐Associated Signaling Nodes in Prostate Stem Cells
Davies, A., & Zoubeidi, A. (2016) · Stem Cells International · doi:10.1155/2016/4829602 · Cited by 9 · see citing works
The androgen receptor in bone marrow progenitor cells negatively regulates fat mass
Russell, P. K., Mangiafico, S. P., Fam, B. C., Clarke, M. V., Marin, E. S., Andrikopoulos, S., Wiren, K. M., Zajac, J. D., & Davey, R. A. (2018) · Journal of Endocrinology · doi:10.1530/joe-17-0656 · Cited by 8 · see citing works
Self-citationHormonal Regulation of Adipogenesis
Lee, M. (2017) · Comprehensive physiology · doi:10.1002/j.2040-4603.2017.tb00782.x · Cited by 7 · see citing works
Kim, J., Taaffe, D. R., Galvao, D. A., Fred Saad, C., & Newton, R. U. (2023) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000323 · Cited by 6 · see citing works
Wiren, K. M., Hashimoto, J. G., & Zhang, X.-W. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23288 · Cited by 5 · see citing works
Self-citationOsteoporosis in men: what is similar and what is different?
Laurent, M. R., Gielen, E., ORWOLL, E. S., & Vanderschueren, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813073-5.00025-3 · Cited by 2 · see citing works
Androgens and Skeletal Biology
Wiren, K. M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00015-7 · Cited by 2 · see citing works
Self-citationPark, D., & Yoon, M. (2017) · Journal of Experimental & Biomedical Sciences/Biomedical Science Letters · doi:10.15616/bsl.2017.23.3.261 · Cited by 1 · see citing works
Androgens and Skeletal Biology: Basic Mechanisms
Wiren, K. M. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-375098-3.50016-0 · Cited by 1 · see citing works
Self-citationConsideration of Biological Sex in Translating Regenerative Stem Cell Therapies
Shapiro, G., Pelled, G., & Gazit, D. (2017) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-12-803506-1.00019-x · Cited by 1 · see citing works
Chapter 15 – Androgens and Skeletal Biology: Basic Mechanisms
Wiren, K. M. (2013) · Cited by 1 · see citing works
Self-citation(2012) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283542fb3
Consideration of biological sex in stem cell therapies
Krut, Z., Pelled, G., Gazit, D., & Gazit, Z. (2023) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-323-88534-8.00032-8
- Authors
- Semirale, A. A., Zhang, X., & Wiren, K. M.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Wiren, Kristine M.
- ORCID
- Wiren, Kristine M.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2011-06-07
- Volume
- 112
- Issue
- 7
- Pages
- 1773-1786
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- PMC
- PMC3111903
- OpenAlex
- W2076433997
- Cited by
- 42
- References
- 54
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 8 · 2016: 1 · 2015: 1 · 2014: 5 · 2013: 4 · 2012: 6
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cellular Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK067541)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- androgen receptor, androgens, mesenchymal stem cells, body composition, fat mass, visceral adipose tissue, adipocyte size, glucose tolerance, progenitor cells, PPARγ, C/EBPα, GLUT4, aging, muscle atrophy, osteopenia
- MeSH terms
- Animals, Blood Glucose, Body Composition, Body Weight, Bone Marrow Cells, Cell Differentiation, Colony-Forming Units Assay, Eating, Female, Glucose Tolerance Test, Insulin, Male, Mice, Transgenic, Motor Activity, Receptors, Androgen, Recombinant Proteins, Skin, Testis, Cell Lineage, Cell Size, Adiposity, Adipogenesis, Mice, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
