The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus
Open accessAbstract
The population structure of Staphylococcus aureus carried by healthy humans was determined using a large strain collection of nonclinical origin (n = 829). High-throughput amplified fragment length polymorphism (AFLP) analysis revealed 3 major and 2 minor genetic clusters of S. aureus, which were corroborated by multilocus sequence typing. Major AFLP cluster I comprised 44.4% of the carriage isolates and showed additional heterogeneity whereas major AFLP groups II and III presented 2 homogeneous clusters, including 47.3% of all carriage isolates. Coanalysis of invasive S. aureus strains and epidemic methicillin-resistant S. aureus (MRSA) revealed that all major clusters contained invasive and multiresistant isolates. However, clusters and subclusters with overrepresentation of invasive isolates were also identified. Bacteremia in elderly adults, for instance, was caused by a IVa cluster-derived strain significantly more often than by strains from other AFLP clusters. Furthermore, expansion of multiresistant clones or clones associated with skin disease (impetigo) was detected, which suggests that epidemic potential is present in pathogenic strains of S. aureus. In addition, the virulence gene encoding Panton-Valentine leukocidin was significantly enriched in S. aureus strains causing abscesses and arthritis in comparison with the carriage group. We provide evidence that essentially any S. aureus genotype carried by humans can transform into a life-threatening human pathogen but that certain clones are more virulent than others.
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2 retracted
A Link Between Virulence and Ecological Abundance in Natural Populations of Staphylococcus aureus
Day, N., Moore, C. E., Enright, M. C., Berendt, A. R., Smith, J. M., Murphy, M. F., Peacock, S. J., Spratt, B. G., & Feil, E. J. (2001) · Science · doi:10.1126/science.1056495 · Cited by 108
RetractedDay, N. P. J., Moore, C. E., Enright, M. C., et al. (2002) · Science · doi:10.1126/science.295.5557.971b · Cited by 9
RetractedAFLP: a new technique for DNA fingerprinting
Vos, P., Hogers, R., Bleeker, M., Reijans, M., Lee, T. V. D., Hornes, M., Friters, A., Pot, J., Paleman, J., Kuiper, M., et al. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.21.4407 · Cited by 12,401
Experimental Design and Data Analysis for Biologists
Quinn, G. P., & Keough, M. J. (2002) · doi:10.1017/cbo9780511806384 · Cited by 10,674
Enright, M. C., Day, N. P. J., Davies, C. E., Peacock, S. J., & Spratt, B. G. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.3.1008-1015.2000 · Cited by 3,063
Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks
Kluytmans, J., van Belkum, A., & Verbrugh, H. (1997) · Clinical Microbiology Reviews · doi:10.1128/cmr.10.3.505 · Cited by 2,595
Self-citationLina, G., Piemont, Y., Godail-Gamot, F., Bes, M., Peter, M.-O., Gauduchon, V., Vandenesch, F., & Etienne, J. (1999) · Clinical Infectious Diseases · doi:10.1086/313461 · Cited by 2,489
Nasal Carriage as a Source of Staphylococcus aureus Bacteremia
von Eiff, C., Becker, K., Machka, K., Stammer, H., & Peters, G. (2001) · New England Journal of Medicine · doi:10.1056/nejm200101043440102 · Cited by 1,984
Whole genome sequencing of meticillin-resistant Staphylococcus aureus
Kuroda, M., Ohta, T., Uchiyama, I., Baba, T., Yuzawa, H., Kobayashi, I., Cui, L., Oguchi, A., Aoki, K.-I., Nagai, Y., et al. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04403-2 · Cited by 1,961
Feil, E. J., Li, B. C., Aanensen, D. M., Hanage, W. P., & Spratt, B. G. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.5.1518-1530.2004 · Cited by 1,861
Cited by
The role of nasal carriage in Staphylococcus aureus infections
Wertheim, H. F., Melles, D. C., Vos, M. C., van Leeuwen, W., van Belkum, A., Verbrugh, H. A., & Nouwen, J. L. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)70295-4 · Cited by 2,685
Self-citationPathogenesis of Methicillin‐Resistant Staphylococcus aureus Infection
Gordon, R. J., & Lowy, F. D. (2008) · Clinical Infectious Diseases · doi:10.1086/533591 · Cited by 961
Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat
Zetola, N., Francis, J. S., Nuermberger, E. L., & Bishai, W. R. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)70112-2 · Cited by 791
The evolution of Staphylococcus aureus
Deurenberg, R. H., & Stobberingh, E. E. (2008) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2008.07.007 · Cited by 721
Insights into Mechanisms Used by Staphylococcus aureus to Avoid Destruction by Human Neutrophils
Voyich, J. M., Braughton, K. R., Sturdevant, D. E., Whitney, A. R., Saïd-Salim, B., Porcella, S. F., Long, R. D., Dorward, D. W., Gardner, D. J., Kreiswirth, B. N., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.6.3907 · Cited by 563
Metadata
- Authors
- Melles, D. C., Gorkink, R. F. J., Boelens, H. A. M., Snijders, S. V., Peeters, J. K., Moorhouse, M. J., van der Spek, P. J., van Leeuwen, W. B., Simons, G., Verbrugh, H. A., & van Belkum, A.
- Venue
- Journal of Clinical Investigation
- Published
- 2004-12-15
- Volume
- 114
- Issue
- 12
- Pages
- 1732-1740
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2145051545
- Cited by
- 255
- References
- 43
- FWCI
- 13.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Melles, D. C., Gorkink, R. F. J., Boelens, H. A. M., Snijders, S. V., Peeters, J. K., Moorhouse, M. J., van der Spek, P. J., van Leeuwen, W. B., Simons, G., Verbrugh, H. A., & van Belkum, A. (2004). Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus. Journal of Clinical Investigation. https://doi.org/10.1172/jci200423083
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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