The DOI matches its OpenAlex record; 8 of the 8 references it cites were found in a registry or an index.
IL-10–producing and naturally occurring CD4+ Tregs: limiting collateral damage
Open accessAbstract
Effective immune responses against pathogens are sometimes accompanied by strong inflammatory reactions. To minimize damage to self, the activation of the immune system also triggers anti-inflammatory circuits. Both inflammatory and anti-inflammatory reactions are normal components of the same immune response, which coordinately fight infections while preventing immune pathology. IL-10 is an important suppressive cytokine, produced by a large number of immune cells in addition to the antigen-driven IL-10-producing regulatory and the naturally occurring suppressor CD4+ T cells, which is a key player in anti-inflammatory immune responses. However, additional mechanisms have evolved to ensure that pathogen eradication is achieved with minimum damage to the host. Here we discuss those mechanisms that operate to regulate effector immune responses.
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Citations
Cites
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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
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The role of IL-10 in promoting disease progression in Leishmaniasis
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Cited by
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Round, J. L., & Mazmanian, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909122107 · Cited by 2,233
Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke
Liesz, A., Suri-Payer, E., Veltkamp, C., Doerr, H., Sommer, C., Rivest, S., Giese, T., & Veltkamp, R. (2009) · Nature Medicine · doi:10.1038/nm.1927 · Cited by 1,115
Regulatory T cells and infection: a dangerous necessity
Belkaid, Y. (2007) · Nature Reviews Immunology · doi:10.1038/nri2189 · Cited by 745
Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection
Shen, Y., Torchia, M. L. G., Lawson, G. W., Karp, C. L., Ashwell, J. D., & Mazmanian, S. K. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.08.004 · Cited by 714
Metadata
- Authors
- O’Garra, A., Vieira, P. L., Vieira, P., & Goldfeld, A. E.
- Venue
- Journal of Clinical Investigation
- Publisher
- American Society for Clinical Investigation
- Published
- 2004-11-15
- Volume
- 114
- Issue
- 10
- Pages
- 1372-1378
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2141783094
- Cited by
- 529
- References
- 8
- FWCI
- 14.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- O’Garra, A., Vieira, P. L., Vieira, P., & Goldfeld, A. E. (2004). IL-10–producing and naturally occurring CD4+ Tregs: limiting collateral damage. Journal of Clinical Investigation. https://doi.org/10.1172/jci200423215
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
