Cited by 316T-cell and B-cell ImmunologyLiver physiology and pathologyLiver Diseases and Immunity

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity

Open access

Bowen, David G., Zen, Monica, Holz, Lauren, Davis, Thomas, McCaughan, Geoffrey W., Bertolino, Patrick·2004·Journal of Clinical Investigation

DOI 10.1172/jci21593PMC PMC514586

Open this paper in CoChat — free account Open PDF

Abstract

Hepatic immunobiology is paradoxical: although the liver possesses unusual tolerogenic properties, it is also the site of effective immune responses against multiple pathogens and subject to immune-mediated pathology. The mechanisms underlying this dichotomy remain unclear. Following previous work demonstrating that the liver may act as a site of primary T cell activation, we demonstrate here that the balance between immunity and tolerance in this organ is established by competition for primary activation of CD8+ T cells between the liver and secondary lymphoid tissues, with the immune outcome determined by the initial site of activation. Using a transgenic mouse model in which antigen is expressed within both liver and lymph nodes, we show that while naive CD8+ T cells activated within the lymph nodes were capable of mediating hepatitis, cells undergoing primary activation within the liver exhibited defective cytotoxic function and shortened half-life and did not mediate hepatocellular injury. The implications of these novel findings may pertain not only to the normal maintenance of peripheral tolerance, but also to hepatic allograft tolerance and the immunopathogenesis of chronic viral hepatitis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci200421593

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Current Protocols in Immunology
(2018) · Current Protocols in Immunology · doi:10.1002/(issn)1934-368x · Cited by 3,574
Hepatitis B Virus Immunopathogenesis
Chisari, F. V., & Ferrari, C. I. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.000333 · Cited by 1,584
Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells
Kaech, S. M., & Ahmed, R. (2001) · Nature Immunology · doi:10.1038/87720 · Cited by 1,265
Cell migration, chimerism, and graft acceptance
Starzl, T. E., Murase, N., Ildstad, S. T., Ricordi, C., Demetris, A. J., & Trucco, M. (1992) · The Lancet · doi:10.1016/0140-6736(92)91840-5 · Cited by 1,051
Induction of Immunological Tolerance by Porcine Liver Allografts
Calne, R. Y., Sells, R. A., Peña, J., Davis, D., Millard, P. R., Herbertson, B. M., BINNS, R. M., & Davies, D. A. L. (1969) · Nature · doi:10.1038/223472a0 · Cited by 837
Naive and memory T cells show distinct pathways of lymphocyte recirculation.
Mackay, C. R., Marston, W. L., & Dudler, L. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.3.801 · Cited by 787
Book review
Brodie, S. E. (1996) · Survey of Ophthalmology · doi:10.1016/s0039-6257(96)80075-0 · Cited by 770
Hepatic T cells and liver tolerance
Crispe, I. N. (2003) · Nature Reviews Immunology · doi:10.1038/nri981 · Cited by 661
Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response.
Missale, G., Bertoni, R., Lamonaca, V., Valli, A., Massari, M., Mori, C., Rumi, M. G., Houghton, M., Fiaccadori, F., & Ferrari, C. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118842 · Cited by 658
Impaired Effector Function of Hepatitis C Virus-Specific CD8+ T Cells in Chronic Hepatitis C Virus Infection
Wedemeyer, H. H., He, X.-S., Nascimbeni, M., Davis, A. R., Greenberg, H. B., Hoofnagle, J. H., Liang, T. J., Alter, H. J., & Rehermann, B. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.3447 · Cited by 635

Flagged first, then by citations

Show all 53 references

Sorted by citations

Items 101–200 of 316

Approaching the Promise of Operational Tolerance in Clinical Transplantation
Bishop, G. A., Ierino, F. L., Sharland, A. F., Hall, B. M., Alexander, S. I., Sandrin, M. S., Coates, P. T., & McCaughan, G. W. (2011) · Transplantation · doi:10.1097/tp.0b013e318215e742 · Cited by 47
Self-citation
Impact of Antigen Presentation Mechanisms on Immune Response in Autoimmune Hepatitis
Fasano, R., Malerba, E., Prete, M., Solimando, A. G., Buonavoglia, A., Silvestris, N., Leone, P., & Racanelli, V. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.814155 · Cited by 50
Adaptive response in hepatitis B virus infection
Loggi, E., Gamal, N., Bihl, F. K., Bernardi, M., & Andreoné, P. (2014) · Journal of Viral Hepatitis · doi:10.1111/jvh.12255 · Cited by 48
What fires prometheus?
Viebahn, C. S., & Yeoh, G. C. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.11.025 · Cited by 46
Critical Role of the Liver in the Induction of Systemic Inflammation in Rats With Preascitic Cirrhosis
Cantera, M., Mun˜oz, L., Borrero, M., Díaz, D., Francés, R., Monserrat, J., Lario, M., Lledó, L., Such, J. M., Álvarez‐Mon, M., et al. (2010) · Hepatology · doi:10.1002/hep.23961 · Cited by 45
Innate and Adaptive Immunopathogeneses in Viral Hepatitis; Crucial Determinants of Hepatocellular Carcinoma
Zaki, M. Y. W., Fathi, A. M., Samir, S., Eldafashi, N., William, K. Y., Nazmy, M., Fathy, M., Gill, U. S., & Shetty, S. (2022) · Cancers · doi:10.3390/cancers14051255 · Cited by 49
Defective T Helper Response of Hepatocyte-Stimulated CD4 T Cells Impairs Antiviral CD8 Response and Viral Clearance
Wiegard, C., Wolint, P., Frenzel, C., Cheruti, U., Schmitt, E., Oxenius, A., Lohse, A. W., & Herkel, J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.09.007 · Cited by 44
Staying local-antigen presentation in the liver
Knolle, P. A. (2016) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.02.009 · Cited by 42
Intrahepatic Activation of Naive CD4+ T Cells by Liver-Resident Phagocytic Cells
Tay, S. S., Wong, Y. C., Roediger, B., Sierro, F., Lü, B., McDonald, D. M., McGuffog, C., Meyer, N. J., Alexander, I. E., Parish, I. A., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400037 · Cited by 42
Self-citation
CD8+ T cell tolerance following antigen recognition on hepatocytes
Holz, L. E., Warren, A., Couteur, D. G. L., Bowen, D. G., & Bertolino, P. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.08.005 · Cited by 44
Self-citation
Why Functional Pre-Erythrocytic and Bloodstage Malaria Vaccines Fail: A Meta-Analysis of Fully Protective Immunizations and Novel Immunological Model
Guilbride, D. L., Gawliński, P., & Guilbride, P. D. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010685 · Cited by 38
Early Intrahepatic Accumulation of CD8+ T Cells Provides a Source of Effectors for Nonhepatic Immune Responses
Polakos, N. K., Klein, I., Richter, M. V., Zaiss, D. M. W., Giannandrea, M., Crispe, I. N., & Topham, D. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.201 · Cited by 38
Cytokine and Chemokine Responses in the Acute Phase of Hepatitis B Virus Replication in Naive and Previously Vaccinated Blood and Plasma Donors
Keating, S. M., Heitman, J. D., Wu, S., Deng, X., Stramer, S. L., Kuhns, M. C., Mullen, C., Norris, P. J., & Busch, M. P. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit563 · Cited by 38
Effective intrahepatic CD8+ T-cell immune responses are induced by low but not high numbers of antigen-expressing hepatocytes
Ochel, A., Cebula, M., Riehn, M., Hillebrand, U., Lipps, C., Schirmbeck, R., Häuser, H., & Wirth, D. (2015) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.80 · Cited by 37
Cellular effector mechanisms againstPlasmodiumliver stages
Frevert, U., & Nardin, E. H. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01211.x · Cited by 36
Immune response and tolerance during chronic hepatitis B virus infection
Bertoletti, A., & Gehring, A. J. (2007) · Hepatology Research · doi:10.1111/j.1872-034x.2007.00221.x · Cited by 36
Potentiating cancer vaccine efficacy in liver cancer
Tagliamonte, M., Petrizzo, A., Mauriello, A., Tornesello, M. L., Buonaguro, F. M., & Buonaguro, L. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1488564 · Cited by 36
Animal models of autoimmune hepatitis
Christen, U. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.05.017 · Cited by 37
Liver Transplant Tolerance and Its Application to the Clinic: Can We Exploit the High Dose Effect?
Cunningham, E. C., Sharland, A. F., & Bishop, G. A. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/419692 · Cited by 35
The chemical, genetic and immunological basis of idiosyncratic drug–induced liver injury
Tailor, A., Faulkner, L., Naisbitt, D. J., & Park, B. K. (2015) · Human & Experimental Toxicology · doi:10.1177/0960327115606529 · Cited by 35
Immunopathogenic Mechanisms of Autoimmune Hepatitis: How Much Do We Know from Animal Models?
Christen, U., & Hintermann, E. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122007 · Cited by 35
Regulatory T-cell therapy in liver transplantation
Whitehouse, G. P., Hope, A. J., & Fueyo, A. S. (2017) · Transplant International · doi:10.1111/tri.12998 · Cited by 35
Tolerance in liver transplantation
Bishop, G. A., Bertolino, P., Bowen, D. G., & McCaughan, G. W. (2012) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2012.01.003 · Cited by 35
Self-citation
Cytokines and chronic liver disease
Fainboim, L., Cherñavsky, A. C., Paladino, N., Flores, A. C., & Arruvito, L. (2007) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2007.01.017 · Cited by 36
DAP12 Promotes IRAK-M Expression and IL-10 Production by Liver Myeloid Dendritic Cells and Restrains Their T Cell Allostimulatory Ability
Sumpter, T. L., Packiam, V. T., Turnquist, H. R., Castellaneta, A., Yoshida, O., & Thomson, A. W. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1000527 · Cited by 34
Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments
Wang, C., Cordoba, S. P., Hu, M., Bertolino, P., Bowen, D. G., Sharland, A. F., Allen, R. D. M., Alexander, S. I., McCaughan, G. W., & Bishop, G. A. (2011) · Transplant Immunology · doi:10.1016/j.trim.2010.12.004 · Cited by 33
Self-citation
HBV-Specific Adaptive Immunity
Bertoletti, A., Tan, A. T., & Gehring, A. J. (2009) · Viruses · doi:10.3390/v1020091 · Cited by 34
Systemic transmigration of allosensitizing donor dendritic cells to host secondary lymphoid organs after rat liver transplantation†
Ueta, H., Shi, C., Miyanari, N., Xu, X., Shu, Z., Yamashita, M., Ezaki, T., & Matsuno, K. (2008) · Hepatology · doi:10.1002/hep.22161 · Cited by 33
CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation
Zeissig, S., Peuker, K., Iyer, S., Gensollen, T., Dougan, S., Olszak, T., Kaser, A., & Blumberg, R. (2017) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1701428114 · Cited by 29
Dendritic Cell-Mediated Regulation of Liver Ischemia-Reperfusion Injury and Liver Transplant Rejection
Nakano, R., Tran, L. M., Geller, D. A., Macedo, C., Metes, D., & Thomson, A. W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.705465 · Cited by 31
Dendritic cells are required for effective cross‐presentation in the murine liver†
Plitas, G., Burt, B. M., Stableford, J. A., Nguyen, H. M., Welles, A. P., & DeMatteo, R. P. (2008) · Hepatology · doi:10.1002/hep.22167 · Cited by 32
Mouse Models for Experimental Autoimmune Hepatitis: Limits and Chances
Hardtke‐Wolenski, M., & Jaeckel, E. (2010) · Digestive Diseases · doi:10.1159/000282067 · Cited by 32
Virus-Specific CD8+ T Cells in the Liver: Armed and Ready to Kill
Keating, R., Yue, W. W., Rutigliano, J. A., So, J., Olivas, E., Thomas, P. G., & Doherty, P. C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.2737 · Cited by 30
Pathogen Infection as a Possible Cause for Autoimmune Hepatitis
Christen, U., & Hintermann, E. (2014) · International Reviews of Immunology · doi:10.3109/08830185.2014.921162 · Cited by 30
The Role of Lymphatic Endothelial Cells in Liver Injury and Tumor Development
Kornek, M. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00548 · Cited by 28
Liver-Targeting Nanoplatforms for the Induction of Immune Tolerance
Kusumoputro, S., Au, C., Lam, K. H., Park, N., Hyun, A., Kusumoputro, E., Wang, X., & Xia, T. (2023) · Nanomaterials · doi:10.3390/nano14010067 · Cited by 31
Differential migration of passenger leukocytes and rapid deletion of naive alloreactive CD8 T cells after mouse liver transplantation
Tay, S. S., Lü, B., Sierro, F., Benseler, V., McGuffog, C., Bishop, A. G., Cowan, P. J., McCaughan, G. W., Dwyer, K. M., Bowen, D. G., et al. (2013) · Liver Transplantation · doi:10.1002/lt.23720 · Cited by 29
Self-citation
The role of hepatic immune regulation in systemic immunity to viral infection
Knolle, P. A., Böttcher, J. P., & Huang, L. (2014) · Medical Microbiology and Immunology · doi:10.1007/s00430-014-0371-0 · Cited by 29
Lymphocyte Loss and Immunosuppression Following Acetaminophen-Induced Hepatotoxicity in Mice as a Potential Mechanism of Tolerance
Masson, M. J., Peterson, R. A., Chung, C. J., Graf, M. L. M., Carpenter, L. D., Ambroso, J. L., Krull, D., Sciarrotta, J., & Pohl, L. R. (2006) · Chemical Research in Toxicology · doi:10.1021/tx060190c · Cited by 29
Liver-resident memory T cells: life in lockdown
Pallett, L. J., & Maini, M. K. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00932-w · Cited by 28
Hepatitis B virus: from immunobiology to immunotherapy
Grimm, D. G., Heeg, M., & Thimme, R. (2012) · Clinical Science · doi:10.1042/cs20120169 · Cited by 28
Balance of inflammatory pathways and interplay of immune cells in the liver during homeostasis and injury
Baeck, C., & Tacke, F. (2014) · Europe PMC (PubMed Central) · doi:10.17877/de290r-15572 · Cited by 28
Effector CD8 T cell trafficking within the liver
Guidotti, L. G., & Iannacone, M. (2012) · Molecular Immunology · doi:10.1016/j.molimm.2012.10.032 · Cited by 28
RNA Interference Therapy for Chronic Hepatitis B Predicts the Importance of Addressing Viral Integration When Developing Novel Cure Strategies
Wooddell, C. I., Gehring, A. J., Yuen, M., & Given, B. D. (2021) · Viruses · doi:10.3390/v13040581 · Cited by 28
New treatments to reach functional cure: Rationale and challenges for emerging immune-based therapies
Gehring, A. J. (2017) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2017.05.004 · Cited by 27
New Animal Models for Autoimmune Hepatitis
Christen, U., Hintermann, E., & Jaeckel, E. (2009) · Seminars in Liver Disease · doi:10.1055/s-0029-1233536 · Cited by 25
Taking off the brakes: T cell immunity in the liver
Kern, M., Popov, A., Kurts, C., Schultze, J. L., & Knolle, P. A. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.06.001 · Cited by 26
Induction of Tolerance in CD8+ T Cells to a Transgenic Autoantigen Expressed in the Liver Does Not Require Cross-Presentation
Morimoto, J. O., Tan, X., Teague, R. M., Öhlén, C., & Greenberg, P. D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6849 · Cited by 25
Naïve CD8 T cell activation by liver bone marrow-derived cells leads to a “neglected” IL-2low Bimhigh phenotype, poor CTL function and cell death
Holz, L. E., Benseler, V., Vo, M., McGuffog, C., van Rooijen, N., McCaughan, G. W., Bowen, D. G., & Bertolino, P. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.05.015 · Cited by 24
Self-citation
Liver Immunology
Bogdanos, D. P., Gao, B., & Gershwin, M. E. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120011 · Cited by 231
Predicting Operational Tolerance in Pediatric Living-Donor Liver Transplantation by Absence of HLA Antibodies
Waki, K., Sugawara, Y., Mizuta, K., Taniguchi, M., Ozawa, M., Hirata, M., Nozawa, M., Kaneko, J., Takahashi, K., Kadowaki, T., et al. (2012) · Transplantation · doi:10.1097/tp.0b013e3182782fef · Cited by 24
Co-culture of primary human tumor hepatocytes from patients with hepatocellular carcinoma with autologous peripheral blood mononuclear cells: study of their in vitro immunological interactions
Doumba, P. P., Nikolopoulou, M., Gomatos, I. P., Konstadoulakis, M. M., & Koskinas, J. S. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-17 · Cited by 24
Intrahepatic Cross-Presentation and Hepatocellular Antigen Presentation Play Distinct Roles in the Induction of Hepatitis B Virus-Specific CD8 + T Cell Responses
Murata, Y., Kawashima, K., Sheikh, K., Tanaka, Y., & Isogawa, M. (2018) · Journal of Virology · doi:10.1128/jvi.00920-18 · Cited by 23
Hepatocellular Carcinoma Tumor Microenvironment and Its Implications in Terms of Anti-tumor Immunity: Future Perspectives for New Therapeutics
Satılmış, B., Şahin, T. T., Çiçek, E., Akbulut, S., & Yılmaz, S. (2021) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-021-00725-8 · Cited by 24
Critical Role for CD1d-Restricted Invariant NKT Cells in Stimulating Intrahepatic CD8 T-Cell Responses to Liver Antigen
Sprengers, D., Sillé, F. C. M., Derkow, K., Besra, G. S., Janssen, H. L. A., Schott, E., & Boes, M. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.02.037 · Cited by 25
Dual muscle-liver transduction imposes immune tolerance for muscle transgene engraftment despite preexisting immunity
Bartolo, L., Tong, S. L. C., Chappert, P., Urbain, D., Collaud, F., Colella, P., Richard, I., Ronzitti, G., Demengeot, J., Gross, D., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.127008 · Cited by 25
Therapeutic Vaccination in Chronic Hepatitis B: Preclinical Studies in the Woodchuck
Kosinska, A. D., Zhang, E., Lu, M., & Roggendorf, M. (2010) · Hepatitis Research and Treatment · doi:10.1155/2010/817580 · Cited by 23
Presentation of HCV antigens to naive CD8+T cells: Why the where, when, what and how are important for virus control and infection outcome
Racanelli, V., & Manigold, T. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.04.009 · Cited by 23
Serum glycan as a prognostic marker in patients with advanced hepatocellular carcinoma treated with sorafenib
Miyahara, K., Nouso, K., Miyake, Y., Nakamura, S., Obi, S., Amano, M., Hirose, K., Nishimura, S., & Yamamoto, K. (2013) · Hepatology · doi:10.1002/hep.26531 · Cited by 23
Impact of immune tolerance mechanisms on the efficacy of immunotherapy in primary and secondary liver cancers
Sankar, K. N., Pearson, A. N., Worlikar, T., Perricone, M. D., Holcomb, E. A., Mendiratta‐Lala, M., Xu, Z., Bhowmick, N. A., & Green, M. D. (2023) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh-23-11 · Cited by 22
Definition of the Chemical and Immunological Signals Involved in Drug-Induced Liver Injury
Ali, S.-E., Waddington, J. C., Park, B. K., & Meng, X. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00275 · Cited by 22
Immune benefit of combined heart and liver transplantation
Ortega–Legaspi, J., Hoteit, M. A., & Wald, J. W. (2020) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000801 · Cited by 20
Regulatory T Cell Therapy Following Liver Transplantation
Yu, J.-J., Liu, Z., Li, C., Wei, Q., Zheng, S., Saeb‐Parsy, K., & Xu, X. (2020) · Liver Transplantation · doi:10.1002/lt.25948 · Cited by 20
Immunotolerance in Liver Transplantation
Mastoridis, S., Martínez‐Llordella, M., & Fueyo, A. S. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1602762 · Cited by 20
Evasion of Pre-Existing Immunity to Cas9: A Prerequisite for Successful Genome Editing In Vivo?
Wignakumar, T., & Fairchild, P. J. (2019) · Current Transplantation Reports · doi:10.1007/s40472-019-00237-2 · Cited by 19
Two immunogenic passenger dendritic cell subsets in the rat liver have distinct trafficking patterns and radiosensitivities
Yu, B., Ueta, H., Kitazawa, Y., Tanaka, T., Adachi, K., Kimura, H., Morita, M., Sawanobori, Y., Qian, H. X., Kodama, T., et al. (2012) · Hepatology · doi:10.1002/hep.25795 · Cited by 19
Gene Therapy for Tolerance
Cunningham, E. C., Tay, S. S., Wang, C., Rtshiladze, M. A., Wang, Z. Z., McGuffog, C., Cubitt, J. J., McCaughan, G. W., Alexander, I. E., Bertolino, P., et al. (2012) · Transplantation · doi:10.1097/tp.0b013e318278d39a · Cited by 21
Self-citation
Immunological Determinants of Liver Transplant Outcomes Uncovered by the Rat Model
Wang, X., MacParland, S. A., & Perciani, C. T. (2021) · Transplantation · doi:10.1097/tp.0000000000003598 · Cited by 19
The CD8 T‐cell response during tolerance induction in liver transplantation
Wong, Y. C., McCaughan, G. W., Bowen, D. G., & Bertolino, P. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.53 · Cited by 19
Self-citation
Mechanisms of T Cell Death in the Liver: To Bim or Not to Bim?
Holz, L. E., Bowen, D. G., & Bertolino, P. (2010) · Digestive Diseases · doi:10.1159/000282060 · Cited by 19
Self-citation
Hepatocytes paradoxically affect intrahepatic IFN-γ production in autoimmune hepatitis due to Gal-9 expression and TLR2/4 ligand release
Mo, R., Feng, X., Wu, Y.-N., Wang, H., He, Y., Sun, H., Guo, F., Chen, Q., Yan, W., Li, P., et al. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.05.014 · Cited by 17
The Liver and the Hepatic Immune Response in Trypanosoma cruzi Infection, a Historical and Updated View
Vacani-Martins, N., Meuser-Batista, M., dos Santos, C. D. L. P., Hasslocher‐Moreno, A. M., & Henriques‐Pons, A. (2021) · Pathogens · doi:10.3390/pathogens10091074 · Cited by 17
Induction of Intrahepatic HCV NS4B, NS5A and NS5B-Specific Cellular Immune Responses following Peripheral Immunization
Kuhs, K. A. L., Toporovski, R., Ginsberg, A. A., Shedlock, D. J., & Weiner, D. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052165 · Cited by 16
Autoimmune hepatitis induction can occur in the liver
Dywicki, J., Buitrago‐Molina, L. E., Pietrek, J., Lieber, M., Broering, R., Khera, T., Schlué, J., Manns, M. P., Wedemeyer, H. H., Jaeckel, E., et al. (2019) · Liver International · doi:10.1111/liv.14296 · Cited by 16
A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice
Tripathi, D., Venkatasubramanian, S., Cheekatla, S. S., Paidipally, P., Welch, E., Tvinnereim, A., & Vankayalapati, R. (2016) · Nature Communications · doi:10.1038/ncomms13896 · Cited by 16
Requirement of secondary lymphoid tissues for the induction of primary and secondary T cell responses against Listeria monocytogenes
Kursar, M., Jänner, N., Pfeffer, K., Brinkmann, V., Kaufmann, S. H. E., & Mittrücker, H. (2007) · European Journal of Immunology · doi:10.1002/eji.200737142 · Cited by 16
Parenchymal Expression of CD86/B7.2 Contributes to Hepatitis C Virus-Related Liver Injury
Sun, J., Tumurbaatar, B., Jia, J., Diao, H., Bodola, F., Lemon, S. M., Tang, W. W., Bowen, D. G., McCaughan, G. W., Bertolino, P., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.16.10730-10739.2005 · Cited by 16
Self-citation
CD8low T-cell subpopulation is increased in patients with chronic hepatitis B virus infection
Ouyang, L., Li, X., Liang, Z., Yang, D., Gong, F., Shen, G., Weng, X., & Wu, X. (2013) · Molecular Immunology · doi:10.1016/j.molimm.2013.07.003 · Cited by 16
Priming of Antiviral CD8 T Cells without Effector Function by a Persistently Replicating Hepatitis C-Like Virus
Hartlage, A. S., Walker, C. M., & Kapoor, A. (2020) · Journal of Virology · doi:10.1128/jvi.00035-20 · Cited by 15
Transplantation Pathology
Clouston, A. D., & Hübscher, S. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-7020-6697-9.00014-5 · Cited by 15
Prospect of the use of checkpoint inhibitors in hepatocellular cancer treatments
Raufi, A. M., & Tirona, M. T. (2017) · Cancer Management and Research · doi:10.2147/cmar.s111673 · Cited by 14
Animal Models for Autoimmune Hepatitis: Are Current Models Good Enough?
Christen, U., & Hintermann, E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.898615 · Cited by 18
Molecular mechanisms of portal vein tolerance
Watanabe, T., Kudo, M., Chiba, T., & Wakatsuki, Y. (2007) · Hepatology Research · doi:10.1111/j.1872-034x.2007.00313.x · Cited by 15
Cellular prognostic markers in hepatocellular carcinoma
Buonaguro, L., Tagliamonte, M., Petrizzo, A., Damiano, E., Tornesello, M. L., & Buonaguro, F. M. (2015) · Future Oncology · doi:10.2217/fon.15.39 · Cited by 14
Peripheral immunization induces functional intrahepatic Hepatitis C specific immunity following selective retention of vaccine-specific CD8 T cells by the liver
Kuhs, K. A. L., Toporovski, R., Ginsberg, A. A., Olsen, A. L., Shedlock, D. J., Morrow, M. P., Yan, J., Wells, R. G., & Weiner, D. B. (2011) · Human Vaccines · doi:10.4161/hv.7.12.18279 · Cited by 14
Mechanisms of Disease: the evolving understanding of liver allograft rejection
Eksteen, B., & Neuberger, J. (2008) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep1070 · Cited by 14
Animal Models for Autoimmune Liver Disease – What Is Relevant for Immune-Mediated Liver Disease
Hardtke‐Wolenski, M., Taubert, R., & Jaeckel, E. (2012) · Digestive Diseases · doi:10.1159/000341114 · Cited by 13
Liver Is Able to Activate Naïve CD8+ T Cells with Dysfunctional Anti-Viral Activity in the Murine System
Lukens, J. R., Dolina, J. S., Kim, T. S., Tacke, R., & Hahn, Y. S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007619 · Cited by 13
Role of T cell death in maintaining immune tolerance during persistent viral hepatitis
Larrubia, J. R. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i12.1877 · Cited by 13
Induction Phase of Spontaneous Liver Transplant Tolerance
Mccaughan, G., Bowen, D., & Bertolino, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01908 · Cited by 10
Self-citation
Soluble N-Acetylgalactosamine-Modified Antigens Enhance Hepatocyte-Dependent Antigen Cross-Presentation and Result in Antigen-Specific CD8+ T Cell Tolerance Development
Damo, M., Wilson, D. S., Watkins, E. A., & Hubbell, J. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.555095 · Cited by 13
Mouse liver-specific CD8+ T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes
Chabot, S., Fakhfakh, A., Béland, K., Lamarre, A., Oldstone, M. B. A., Álvarez, F., & Djilali-Saiah, I. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.10.002 · Cited by 13
Le foie : un organe du système immunitaire ?
Lapierre, P., & Álvarez, F. (2007) · médecine/sciences · doi:10.1051/medsci/20072311985 · Cited by 13
Tumor-infiltrating lymphocyte activity is enhanced in tumors with low IL-10 production in HBV-induced hepatocellular carcinoma
Shi, Y., Song, Q., Hu, D., Zhuang, X., & Yu, S. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.03.177 · Cited by 13
Unconventional antigen-presenting cells in the induction of peripheral CD8+ T cell tolerance
Reynoso, E. D., & Turley, S. J. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0509362 · Cited by 13
Mechanism, Pathology, and Clinical Presentation of Hepatotoxicity of Anesthetic Agents
Kenna, J. G. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-387817-5.00023-6 · Cited by 13
Different sites of xenoantigen delivery lead to a virally induced late‐onset hepatitis in mice through molecular mimicry
Piché, C., Béland, K., Lapierre, P., Bernard Massie, B., & Álvarez, F. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02600.x · Cited by 12
Role of the Hepatic Parenchyma in Liver Transplant Tolerance: A Paradigm Revisited
Benseler, V., Tay, S. S., Bowen, D. G., & Bertolino, P. (2011) · Digestive Diseases · doi:10.1159/000329802 · Cited by 12
Self-citation
Unique CD8+ T Cell–Mediated Immune Responses Primed in the Liver
Zimmerer, J. M., Horne, P. H., Fisher, M. G., Pham, T., Lunsford, K. E., Ringwald, B. A., Avila, C. L., & Bumgardner, G. L. (2016) · Transplantation · doi:10.1097/tp.0000000000001290 · Cited by 12
The differential organogenesis and functionality of two liver-draining lymph nodes in mice
Yu, J., Chen, Y., Wu, Y., Ye, L., Lian, Z., Wei, H., Sun, R., & Tian, Z. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.08.005 · Cited by 12

Authors: Bowen, D. G., Zen, M., Holz, L., Davis, T., McCaughan, G. W., & Bertolino, P.
Affiliations: Centenary Institute (AU)
ORCID: Bowen, David G.
Zen, Monica
Holz, Lauren
McCaughan, Geoffrey W.
Bertolino, Patrick
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2004-09-01
Volume: 114
Issue: 5
Pages: 701-712
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci21593
PMC: PMC514586
OpenAlex: W1968141301
Cited by: 316
References: 53
Citations by year: 2026: 3 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 11 · 2020: 11 · 2019: 12 · 2018: 11 · 2017: 14 · 2016: 15 · 2015: 14 · 2014: 18 · 2013: 27 · 2012: 23
FWCI: 6.14
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Children’s Hospital of Wisconsin Research Institute
University of Sydney
Medical Research Council
National Health and Medical Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
Keywords: liver, CD8+ T cells, peripheral tolerance, secondary lymphoid organs, hepatitis, cytotoxic function, chronic viral hepatitis, transgenic mouse model
MeSH terms: Adjuvants, Immunologic, Animals, Antibodies, Monoclonal, Hepatitis, Immune Tolerance, Liver, Lymph Nodes, T-Lymphocytes, CD8-Positive T-Lymphocytes, L-Selectin, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks