The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Morphogenesis of the right ventricle requires myocardial expression of Gata4
Open accessAbstract
Mutations in developmental regulatory genes have been found to be responsible for some cases of congenital heart defects. One such regulatory gene is Gata4, a zinc finger transcription factor. In order to circumvent the early embryonic lethality of Gata4-null embryos and to investigate the role of myocardial Gata4 expression in cardiac development, we used Cre/loxP technology to conditionally delete Gata4 in the myocardium of mice at an early and a late time point in cardiac morphogenesis. Early deletion of Gata4 by Nkx2-5Cre resulted in hearts with striking myocardial thinning, absence of mesenchymal cells within the endocardial cushions, and selective hypoplasia of the RV. RV hypoplasia was associated with downregulation of Hand2, a transcription factor previously shown to regulate formation of the RV. Cardiomyocyte proliferation was reduced, with a greater degree of reduction in the RV than in the LV. Late deletion of Gata4 by Cre recombinase driven by the alpha myosin heavy chain promoter did not selectively affect RV development or generation of endocardial cushion mesenchyme but did result in marked myocardial thinning with decreased cardiomyocyte proliferation, as well as double-outlet RV. Our results demonstrate a general role of myocardial Gata4 in regulating cardiomyocyte proliferation and a specific, stage-dependent role in regulating the morphogenesis of the RV and the atrioventricular canal.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
CDK inhibitors: positive and negative regulators of G1-phase progression
Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.12.1501 · Cited by 6,115
The incidence of congenital heart disease.
Hoffman, J. I. E., & Kaplan, S. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01886-7 · Cited by 6,099
Burnside, R. D. (2015) · Cytogenetic and Genome Research · doi:10.1159/000438708 · Cited by 1,946
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
Garg, V., Kathiriya, I. S., Barnes, R., Schluterman, M. K., King, I. N., Butler, C. A., Rothrock, C. R., Eapen, R. S., Hirayama-Yamada, K., Joo, K., et al. (2003) · Nature · doi:10.1038/nature01827 · Cited by 1,236
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.
Molkentin, J. D., Lin, Q., Duncan, S. A., & Olson, E. N. (1997) · Genes & Development · doi:10.1101/gad.11.8.1061 · Cited by 1,150
Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome
Basson, C. T., Bachinsky, D. R., Lin, R. C., Levi, T., Elkins, J. A., Soults, J., Grayzel, D., Kroumpouzou, E., Traill, T. A., Leblanc-Straceski, J., et al. (1997) · Nature Genetics · doi:10.1038/ng0197-30 · Cited by 1,093
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.
Kuo, C. T., Morrisey, E. E., Anandappa, R., Sigrist, K., Lu, M. M., Parmacek, M. S., Soudais, C., & Leiden, J. M. (1997) · Genes & Development · doi:10.1101/gad.11.8.1048 · Cited by 1,037
Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice
Lindsay, E. A., Vitelli, F., Su, H., Morishima, M., Huynh, T., Pramparo, T., Jurecic, V., Ogunrinu, G., Sutherland, H. F., Scambler, P. J., et al. (2001) · Nature · doi:10.1038/35065105 · Cited by 1,017
TBX1 Is Responsible for Cardiovascular Defects in Velo-Cardio-Facial/DiGeorge Syndrome
Merscher, S., Funke, B., Epstein, J. A., Heyer, J., Puech, A., Lu, M. M., Xavier, R. J., Demay, M. B., Russell, R. G., Factor, S., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00247-1 · Cited by 982
The Zinc Finger-containing Transcription Factors GATA-4, -5, and -6
Molkentin, J. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000029200 · Cited by 880
Cited by
Voelkel, N. F., Quaife, R. A., Leinwand, L. A., Barst, R. J., McGoon, M. D., Meldrum, D. R., Dupuis, J., Long, C. S., Rubin, L. J., Smart, F. W., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.632208 · Cited by 1,250
Discovery of Endothelial to Mesenchymal Transition as a Source for Carcinoma-Associated Fibroblasts
Zeisberg, E. M., Potenta, S., Xie, L., Zeisberg, M., & Kalluri, R. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-3127 · Cited by 1,011
Self-citationThymosin β4 induces adult epicardial progenitor mobilization and neovascularization
Smart, N., Risebro, C. A., Melville, A. A. D., Moses, K., Schwartz, R. J., Chien, K. R., & Riley, P. R. (2007) · Nature · doi:10.1038/nature05383 · Cited by 631
Self-citationOka, T., Maillet, M., Watt, A. J., Schwartz, R. J., Aronow, B. J., Duncan, S. A., & Molkentin, J. D. (2006) · Circulation Research · doi:10.1161/01.res.0000215985.18538.c4 · Cited by 423
Self-citationEmbryonic Heart Progenitors and Cardiogenesis
Brade, T., Pane, L. S., Moretti, A., Chien, K. R., & Laugwitz, K.-L. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a013847 · Cited by 254
Metadata
- Authors
- Zeisberg, E. M., Ma, Q., Juraszek, A. L., Moses, K., Schwartz, R. J., Izumo, S., & Pu, W. T.
- Venue
- Journal of Clinical Investigation
- Published
- 2005-06-01
- Volume
- 115
- Issue
- 6
- Pages
- 1522-1531
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2099140108
- Cited by
- 262
- References
- 58
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Morphogenesis of the right ventricle requires myocardial expression of Gata4. https://app.cochat.ai/papers/10.1172/jci23769
- The paper
- Zeisberg, E. M., Ma, Q., Juraszek, A. L., Moses, K., Schwartz, R. J., Izumo, S., & Pu, W. T. (2005). Morphogenesis of the right ventricle requires myocardial expression of Gata4. Journal of Clinical Investigation. https://doi.org/10.1172/jci23769
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
