The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Schoenheimer effect explained–feedback regulation of cholesterol synthesis in mice mediated by Insig proteins
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Loss of Insig2 does not affect plasma cholesterol levels in mice.
“Loss of Insig2 does, however, not affect plasma cholesterol levels in mice.11”
A drop in ER cholesterol leads to a conformational change in SCAP, dissociation from INSIG, and COPII-mediated trafficking of the SCAP-SREBP complex to the Golgi.
“A drop in cholesterol in the ER membrane leads to a conformational change in SCAP11,12, which leads to dissociation from INSIG and facilitates COPII-mediated trafficking of the SCAP-SREBP complex to the Golgi13–15.”
From Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism (2020) · cites this paper as [14]
INSIG1 deficiency or activation of its downstream signaling promotes increased cellular cholesterol levels.
“These findings are consistent with previous studies demonstrating that INSIG1 deficiency or activation of its downstream signaling promotes increased cellular cholesterol levels55,56.”
From Macrophage INSIG1 deficiency drives psoriasiform dermatitis via the SREBP2-STAT1 axis (2026) · cites this paper as [55]
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Rohlmann, A., Gotthardt, M., Hammer, R. E., & Herz, J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1240 · Cited by 455 · cited 1×
“Insig1+/f mice were bred to MX1-Cre transgenic mice to generate Insig1f/f MX1-Cre (L-Insig1–/–) mice (43).”
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Research works printed but not linked: 16
- Brown, M.S., and Goldstein, J.L. 1997. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor [review]. Cell. 89:331-340.
- Nohturfft, A., DeBose-Boyd, R.A., Scheek, S., Gold- stein, J.L., and Brown, M.S. 1999. Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi. Proc. Natl. Acad. Sci. U. S. A. 96:11235-11240.
- Espenshade, P.J., Li, W.-P., and Yabe, D. 2002. Ste- rols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER. Proc. Natl. Acad. Sci. U. S. A. 99:11694-11699.
- Yabe, D., Brown, M.S., and Goldstein, J.L. 2002. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regula- tory element-binding proteins. Proc. Natl. Acad. Sci.
- Brown, M.S., and Goldstein, J.L. 1999. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc. Natl. Acad. Sci.
- Chen, G., Liang, G., Ou, J., Goldstein, J.L., and Brown, M.S. 2004. Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcrip- tion and stimulation of fatty acid synthesis in liver. Proc. Natl. Acad. Sci. U. S. A. 101:11245-11250.
- Yabe, D., Komuro, R., Liang, G., Goldstein, J.L., and Brown, M.S. 2003. Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis. Proc. Natl. Acad. Sci. U. S. A. 100:3155-3160.
- Engelking, L.J., et al. 2004. Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimu- lated lipogenesis. J. Clin. Invest. 113:1168-1175. doi:10.1172/JCI200420978. · DOI
- Repa, J.J., and Mangelsdorf, D.J. 2002. The liver X receptor gene team: potential new players in ath- erosclerosis [review]. Nat. Med. 8:1243-1248.
- Sato, R., Goldstein, J.L., and Brown, M.S. 1993. Replacement of serine-871 of hamster 3-hydroxy-3- methylglutaryl CoA reductase prevents phosphory- lation by AMP-activated kinase and blocks inhibi- tion of sterol synthesis induced by ATP depletion. Proc. Natl. Acad. Sci. U. S. A. 90:9261-9265.
- Horton, J.D., Goldstein, J.L., and Brown, M.S. 2002. SREBPs: activators of the complete program of cho- lesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109:1125-1131. doi:10.1172/JCI200215593. · DOI
- DeBose-Boyd, R.A., Ou, J., Goldstein, J.L., and Brown, M.S. 2001. Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. Proc. Natl. Acad. Sci. U. S. A. 98:1477-1482.
- Matsuda, M., et al. 2001. SREBP cleavage-activating protein (SCAP) is required for increased lipid syn- thesis in liver induced by cholesterol deprivation and insulin elevation. Genes Dev. 15:1206-1216.
- Yang, J., et al. 2001. Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene. Proc. Natl. Acad. Sci. U. S. A. 98:13607-13612.
- Lakso, M., et al. 1996. Efficient in vivo manipula- tion of mouse genomic sequences at the zygote stage. Proc. Natl. Acad. Sci. U. S. A. 93:5860-5865.
- Shimomura, I., et al. 1997. Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver. Proc. Natl. Acad. Sci. U. S. A. 94:12354-12359.
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Espenshade, P. J., & Hughes, A. L. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130315 · Cited by 593
DeBose-Boyd, R. A. (2008) · Cell Research · doi:10.1038/cr.2008.61 · Cited by 391
Regulation of HMG-CoA reductase in mammals and yeast
Burg, J. S., & Espenshade, P. J. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.07.002 · Cited by 303
Knebel, B., Haas, J., Hartwig, S., Jacob, S., Köllmer, C., Nitzgen, U., Muller–Wieland, D., & Kotzka, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031812 · Cited by 162
“The release of the transcriptionally active domain is tightly regulated by a step-wise proteolytic cascade [31,33].”
BackgroundEngelking, L. J., Evers, B. M., Richardson, J. A., Goldstein, J. L., Brown, M. S., & Liang, G. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28988 · Cited by 82
Self-citationNadeau, K. J., Ehlers, L. B., Aguirre, L. E., Moore, R. L., Jew, K. N., Ortmeyer, H. K., Hansen, B. C., Reusch, J. E. B., & Draznin, B. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00543.2005 · Cited by 57
Azzu, V., Vacca, M., Kamzolas, I., Hall, Z., Leslie, J., Carobbio, S., Virtue, S., Davies, S. E., Lukasik, A., Dale, M., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101210 · Cited by 52
Loregger, A., Raaben, M., Nieuwenhuis, J., Tan, J. M. E., Jae, L. T., van den Hengel, L. G., Hendrix, S., van den Berg, M., Scheij, S., Song, J.-Y., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14811-1 · Cited by 51
Rimbert, A., Dalila, N., Wolters, J. C., Huijkman, N., Smit, M., Kloosterhuis, N., Riemsma, M., van der Veen, Y., Singla, A., van Dijk, F., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz727 · Cited by 24
Watanabe, S., Katsube, T., Hattori, H., Sato, H., Ishijima, T., Nakai, Y., Abe, K., & Sonomoto, K. (2013) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2013.01.009 · Cited by 18
Macrophage INSIG1 deficiency drives psoriasiform dermatitis via the SREBP2-STAT1 axis
Li, X., Zang, Y., Li, X., Sheng, T., Liu, S., Chen, L., Xu, X., Wang, L., Long, R., Zhang, M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-73278-8 · Cited by 1
Metadata
- Authors
- Engelking, L. J.
- Venue
- Journal of Clinical Investigation
- Published
- 2005-08-25
- Volume
- 115
- Issue
- 9
- Pages
- 2489-2498
- ISSN
- 0021-9738
- Cited by
- 193
- References
- 1
- Language
- en
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