Cited by 303Cholesterol and Lipid MetabolismCancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Regulation of HMG-CoA reductase in mammals and yeast

Open access
Burg, John S., Espenshade, Peter J.·2011·Progress in Lipid Research

Abstract

HMG-CoA reductase (HMGR), a highly conserved, membrane-bound enzyme, catalyzes a rate-limiting step in sterol and isoprenoid biosynthesis and is the primary target of hypocholesterolemic drug therapy. HMGR activity is tightly regulated to ensure maintenance of lipid homeostasis, disruption of which is a major cause of human morbidity and mortality. HMGR regulation takes place at the levels of transcription, translation, post-translational modification and degradation. In this review, we discuss regulation of mammalian, Saccharomyces cerevisiae and Schizosaccharomyces pombe HMGR and highlight recent advances in the field. We find that the general features of HMGR regulation, including a requirement for the HMGR-binding protein Insig, are remarkably conserved between mammals and ascomycetous fungi, including S. cerevisiae and S. pombe. However the specific details by which this regulation occurs differ in surprising ways, revealing the broad evolutionary themes underlying both HMGR regulation and Insig function.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.plipres.2011.07.002

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A key checkpoint for ergosterol biosynthesis involves the synthesis of HMG-CoA, catalyzed by HMGR.

    “A key checkpoint for ergosterol biosynthesis involves the synthesis of HMG-CoA, catalyzed by HMGR (reviewed in [62]).”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

2 of the 74 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Burg, J. S., & Espenshade, P. J.
Affiliations
Johns Hopkins University (US)
Corresponding author
Espenshade, Peter J.
Venue
Progress in Lipid Research
Publisher
Elsevier BV
Published
2011-10
Volume
50
Issue
4
Pages
403-410
ISSN
0163-7827 (ISSN-L)
OpenAlex
W2086024248
Cited by
303
References
74
Citations by year
2026: 19 · 2025: 24 · 2024: 22 · 2023: 19 · 2022: 24 · 2021: 23 · 2020: 30 · 2019: 25 · 2018: 18 · 2017: 16 · 2016: 15 · 2015: 12 · 2014: 13 · 2013: 23 · 2012: 19
FWCI
3.24
Type
journal article
Language
en
Open access
Locations
  • Progress in Lipid Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • American Heart Association
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R01HL077588, HL 077588)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079637)
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
HMG-CoA reductase, Insig, sterol biosynthesis, isoprenoid biosynthesis, lipid homeostasis, transcriptional regulation, post-translational modification, protein degradation, cholesterol-lowering drugs, Saccharomyces cerevisiae, Schizosaccharomyces pombe, evolutionary conservation, membrane-bound enzyme
MeSH terms
Acyl Coenzyme A, Adenylate Kinase, Animals, Gene Expression Regulation, Humans, Hydroxymethylglutaryl CoA Reductases, Mammals, Membrane Proteins, Protein Binding, Protein Processing, Post-Translational, Saccharomyces cerevisiae, Schizosaccharomyces, Sterols, Signal Transduction, Intracellular Signaling Peptides and Proteins, Protein Phosphatase 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review