Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight
DOI 10.1172/jci25977
Cited by (569)
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- Adipocytokines in Thyroid DysfunctionBerna İmge Aydoğan, Mustafa Şahi̇n · 2013 · ISRN Inflammation
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- An adipobiological model for weight regain after weight lossEdwin C.M. Mariman · 2011 · Adipobiology
- Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the BrainMichael V. Morabito, Yann Ravussin, Bridget R. Mueller, Alicja A. Skowronski, Kazuhisa Watanabe, Kylie S. Foo, Samuel X. Lee, Anders Lehmann, Stephan Hjorth, Lori M. Zeltser et al. · 2017 · PLoS ONE
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- Salivary habituation to food stimuli in successful weight loss maintainers, obese and normal-weight adultsDale S. Bond, Hollie A. Raynor, Jeanne M. McCaffery, Rena R. Wing · 2009 · International Journal of Obesity
- Effects of a novel MC4R agonist on maintenance of reduced body weight in diet‐induced obese miceAlicja A. Skowronski, Michael V. Morabito, Bridget R. Mueller, Samuel Lee, Stephan Hjorth, Anders Lehmann, Kazuhisa Watanabe, Lori M. Zeltser, Yann Ravussin, MICHAEL S. ROSENBAUM et al. · 2013 · Obesity
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- The role of physical activity in maintaining a reduced weightDarcy LaRae Johannsen, Leanne Maree Redman, Éric Ravussin · 2007 · Current Atherosclerosis Reports
- Progressos recentes e novas perspectivas em farmacoterapia da obesidadeAndré Murad Faria, Márcio C. Mancini, Maria Edna de Melo, Cíntia Cercato, Alfredo Halpern · 2010 · Arquivos Brasileiros de Endocrinologia & Metabologia
- 'Functional' body composition: differentiating between benign and non-benign obesityManfred James Müller, Anja Bosy‐Westphal, Martin Heller · 2009 · F1000 Biology Reports
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- Pharmacotherapy for obesityLisa M. Neff, Louis J. Aronne · 2007 · Current Atherosclerosis Reports
- Energy homeostasis in leptin deficient Lepob/ob miceAlicja A. Skowronski, Yann Ravussin, Rudolph L. Leibel, Charles A. LeDuc · 2017 · PLoS ONE
- Adipocytokine correlations with thyroid function and autoimmunity in euthyroid sardiniansAlessandro Delitala, Maristella Steri, Edoardo Fiorillo, Michele Marongiu, Edward G. Lakatta, David Schlessinger, Francesco Cucca · 2018 · Cytokine
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- Effect of Over- and Underfeeding on Body Composition and Related Metabolic Functions in HumansManfred James Müller, Anja Bosy‐Westphal · 2019 · Current Diabetes Reports
- Dynamic changes in energy expenditure in response to underfeeding: a reviewAoife M Egan, Adam L. Collins · 2021 · Proceedings of The Nutrition Society
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- Does circulating leptin play a role in energy expenditure?Xinyan Bi, Yi Ting Loo, Christiani Jeyakumar Henry · 2018 · Nutrition
- Metabolic Responses to Weight PerturbationRudolph L. Leibel, MICHAEL S. ROSENBAUM · 2010 · Research and perspectives in endocrine interactions
- Leptin-based therapeuticsLaura M. Scolaro, Marco Cassone, Jerzy W. Kolaczynski, László Ötvös, Eva Surmacz · 2010 · Expert Review of Endocrinology & Metabolism
- Recent Advances in Anti-Obesity AgentsMin Kyung Kim, Chul Sik Kim · 2018 · Korean Journal of Medicine
- The Impact of Long-term Physical Inactivity on Adipose Tissue ImmunometabolismWilliam V. Trim, Jean‐Philippe Walhin, Françoise Koumanov, Anne Bouloumié, Mark A. Lindsay, Rebecca L. Travers, James E Turner, Dylan Thompson · 2021 · The Journal of Clinical Endocrinology & Metabolism
- Association of triiodothyronine levels with future development of metabolic syndrome in euthyroid middle-aged subjects: a 6-year retrospective longitudinal studyHye Jeong Kim, Ji Cheol Bae, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh, Myung Hi Yoo, Jae Hwan Jee, Jae Hyeon Kim, Yong‐Ki Min, Sun Wook Kim et al. · 2017 · European Journal of Endocrinology
- Macronutrient Content of the Diet: What Do We Know About Energy Balance and Weight Maintenance?Jennifer A Fleming, Penny M. Kris‐Etherton · 2016 · Current Obesity Reports
- Impact of Hepatic Steatosis on Resting Metabolic Rate and Metabolic Adaptation in Response to Intentional Weight LossVikrant P. Rachakonda, James P. DeLany, Erin E. Kershaw, Jaideep Behari · 2019 · Hepatology Communications
- Serum leptin concentration in women of reproductive age with euthyroid autoimmune thyroiditisArtur Drobniak, Krzysztof Kanecki, Monika Grymowicz, Stanisław Radowicki · 2015 · Gynecological Endocrinology
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- Intracellular leptin signaling following effective weight lossAyse Sahin-Efe, Stergios A. Pοlyzos, Fadime Dincer, Lesya Zaichenko, Rosemary McGovern, Benjamin E. Schneider, Christos Socrates Mantzoros · 2015 · Metabolism
- Pharmacologic Approaches to Weight Management: Recent Gains and Shortfalls in Combating ObesityKatherine H. Saunders, Rekha B. Kumar, Leon I. Igel, Louis J. Aronne · 2016 · Current Atherosclerosis Reports
- Auto-Regulation of Leptin NeurobiologyCharles A. LeDuc, Rudolph L. Leibel · 2019 · Cell Metabolism
- Tackling obesity: new therapeutic agents for assisted weight lossSamy McFarlane · 2010 · Diabetes Metabolic Syndrome and Obesity
- Treatment of Obesity and Diabetes in Mice by Transplant of Gut Cells Engineered to Produce LeptinSarah Natasha Oosman, Ada Lam, George Harb, Suraj Unniappan, Ni T. Lam, Travis D. Webber, Daniel Bruch, Qiuxia Zhang, Gregory S. Korbutt, Timothy J. Kieffer · 2008 · Molecular Therapy
- Hormone-based therapies in the regulation of fuel metabolism and body weightNicole C. Kesty, Jonathan David Roth, David G. Maggs · 2008 · Expert Opinion on Biological Therapy
- Principles of Human Energy MetabolismJosé Eduardo Galgani, Éric Ravussin · 2010 · Springer eBooks
- Treatment of Obesity in the Primary Care SettingLouis J. Aronne, Judy Townsend · 2012 · Wiley eBooks
- Brain Insulin and Leptin Signaling in Metabolic ControlThomas Scherer, Hendrik Lehnert, Manfred Hallschmid · 2013 · Endocrinology and Metabolism Clinics of North America
- W(h)ither Metreleptin for Lipodystrophy and the Metabolic Syndrome?Christos Socrates Mantzoros · 2010 · Endocrine Practice
- Maintaining Weight Loss: an Ongoing ChallengePriya Sumithran, Joseph Proietto · 2016 · Current Obesity Reports
- Metabolic Benefits of Prior Weight Loss with and without Exercise on Subsequent 6‐Month Weight RegainAlice S. Ryan, Monica C. Serra, Andrew P. Goldberg · 2017 · Obesity
- Adaptive thermogenesis: Do we need new thinking?Manfred James Müller · 2016 · Obesity
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- Leptin and the skeleton—where is the fat?Catherine M. Gordon · 2011 · Metabolism
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- Liver function parameters, cholesterol, and phospholipid α-linoleic acid are associated with adipokine levels in overweight and obese adultsBelinda R. Gray, Frederik J. Steyn, Peter S.W. Davies, Luis Vitetta · 2014 · Nutrition Research
- Obesity, metabolic syndrome, and disorders of energy balanceRam Weiss, Robert H. Lustig · 2014 · Elsevier eBooks
- Body mass analysis in patients with Hashimoto thyroiditisAnna Popławska‐Kita, Beata Telejko, Katarzyna Siewko, Maria Kościuszko-Zdrodowska, Natalia Wawrusiewicz‐Kurylonek, Adam Jacek Kretowski, Justyna Hryiewicka, Janusz Bogdan Dzięcioł, Witold Bauer, Małgorzata Szelachowska et al. · 2014 · Endocrine Abstracts
- Changes in Energy Expenditure of Patients with Obesity Following Bariatric Surgery: a Systematic Review of Prospective Studies and Meta-analysisKun Li, Wentao Shi, Feng Zhao, Chengcan Yang, Qiancheng Dai, Bing Wang, Yousheng Li · 2019 · Obesity Surgery
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