The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4
Open accessAbstract
HIV-1 envelope glycoproteins (Env), expressed at the cell surface, induce apoptosis of uninfected CD4+ T cells, contributing to the development of AIDS. Here we demonstrate that, independently of HIV replication, transfected or HIV-infected cells that express Env induced autophagy and accumulation of Beclin 1 in uninfected CD4+ T lymphocytes via CXCR4. The same phenomena occurred in a T cell line and in transfected HEK.293 cells that expressed both wild-type CXCR4 and a truncated form of CD4 that is unable to bind the lymphocyte-specific protein kinase Lck. Env-mediated autophagy is required to trigger CD4+ T cell apoptosis since blockade of autophagy at different steps, by either drugs (3-methyladenine and bafilomycin A1) or siRNAs specific for Beclin 1/Atg6 and Atg7 genes, totally inhibited the apoptotic process. Furthermore, CD4+ T cells still underwent Env-mediated cell death with autophagic features when apoptosis was inhibited. These results suggest that HIV-infected cells can induce autophagy in bystander CD4+ T lymphocytes through contact of Env with CXCR4, leading to apoptotic cell death, a mechanism most likely contributing to immunodeficiency.
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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
Induction of autophagy and inhibition of tumorigenesis by beclin 1
Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347
The role of autophagy during the early neonatal starvation period
Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., & Mizushima, N. (2004) · Nature · doi:10.1038/nature03029 · Cited by 2,865
Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
Lum, J. J., Bauer, D. E., Kong, M., Harris, M. H., Li, C., Lindsten, T., & Thompson, C. B. (2005) · Cell · doi:10.1016/j.cell.2004.11.046 · Cited by 1,487
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
Shimizu, S., Kanaseki, T., Mizushima, N., Mizuta, T., Arakawa-Kobayashi, S., Thompson, C. B., & Tsujimoto, Y. (2004) · Nature Cell Biology · doi:10.1038/ncb1192 · Cited by 1,358
Yamamoto, A., Tagawa, Y., Yoshimori, T., Moriyama, Y., Masaki, R., & Tashiro, Y. (1998) · Cell Structure and Function · doi:10.1247/csf.23.33 · Cited by 1,312
Molecular dissection of autophagy: two ubiquitin-like systems
Ohsumi, Y. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35056522 · Cited by 1,240
Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy
Paludan, C., Schmid, D., Landthaler, M., Vockerodt, M., Kube, D., Tuschl, T., & Münz, C. (2005) · Science · doi:10.1126/science.1104904 · Cited by 860
Beclin–phosphatidylinositol 3‐kinase complex functions at the trans‐Golgi network
Kihara, A., Kabeya, Y., Ohsumi, Y., & Yoshimori, T. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve061 · Cited by 813
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Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Autophagic cell death: the story of a misnomer
Kroemer, G., & Levine, B. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2529 · Cited by 1,453
A critical role for the autophagy gene Atg5 in T cell survival and proliferation
Pua, H. H., Dzhagalov, I., Chuck, M., Mizushima, N., & He, Y.-W. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061303 · Cited by 622
“CD4+ human umbilical cord T cells also can be induced to form autophagosomes by the HIV-1 envelope glycoprotein (22).”
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages
Kyei, G. B., Dinkins, C., Davis, A. S., Roberts, E., Singh, S. B., Dong, C., Wu, L., Kominami, E., Ueno, T., Yamamoto, A., et al. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903070 · Cited by 509
Macroautophagy Regulates Energy Metabolism during Effector T Cell Activation
Hubbard, V. M., Valdor, R., Patel, B., Singh, R., Cuervo, A. M., & Macian, F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000576 · Cited by 275
How DNA lesions are turned into powerful killing structures: Insights from UV-induced apoptosis
Batista, L. F. Z., Kaina, B., Meneghini, R., & Menck, C. F. M. (2009) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.09.001 · Cited by 234
Organelle-Specific Initiation of Autophagy
Sica, V., Galluzzi, L., Bravo-San Pedro, J. M., Izzo, V., Maiuri, M. C., & Kroemer, G. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.021 · Cited by 205
Phadwal, K., Alegre-Abarrategui, J., Watson, A. S., Pike, L., Anbalagan, S., Hammond, E. M., Wade-Martins, R., McMichael, A., Klenerman, P., & Simon, A. K. (2012) · Autophagy · doi:10.4161/auto.18935 · Cited by 155
Macroautophagy is deregulated in murine and human lupus T lymphocytes
Gros, F., Arnold, J., Page, N., Décossas, M., Korganow, A.-S., Martin, T., & Muller, S. (2012) · Autophagy · doi:10.4161/auto.20275 · Cited by 155
Wang, M., Hossain, M. S., Tan, W., Coolman, B., Zhou, J., Liu, S., & Casey, P. J. (2010) · Oncogene · doi:10.1038/onc.2010.247 · Cited by 75
DRAM Triggers Lysosomal Membrane Permeabilization and Cell Death in CD4+ T Cells Infected with HIV
Laforge, M., Limou, S., Harper, F., Casartelli, N., Rodrigues, V., Silvestre, R., Haloui, H., Zagury, J.-F., Senik, A., & Estaquier, J. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003328 · Cited by 70
Loss of autophagy promotes murine acetaminophen hepatotoxicity
Igusa, Y., Yamashina, S., Izumi, K., Inami, Y., Fukada, H., Komatsu, M., Tanaka, K., Ikejima, K., & Watanabe, S. (2012) · Journal of Gastroenterology · doi:10.1007/s00535-011-0500-0 · Cited by 66
Atg1 allows second-signaled autophagic cell death in Dictyostelium
Luciani, M.-F., Giusti, C., Harms, B., Oshima, Y., Kikuchi, H., Kubohara, Y., & Golstein, P. (2011) · Autophagy · doi:10.4161/auto.7.5.14957 · Cited by 35
Trinité, B., Chan, C. N., Lee, C. S., & Levy, D. N. (2016) · Journal of Virology · doi:10.1128/jvi.01770-15 · Cited by 19
Metadata
- Authors
- Espert, L.
- Venue
- Journal of Clinical Investigation
- Published
- 2006-08-01
- Volume
- 116
- Issue
- 8
- Pages
- 2161-2172
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2069233591
- Cited by
- 446
- References
- 10
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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