Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2.
DOI 10.1172/jci2673
Cited by (254)
Items 201–254 of 254
- Molecular characterization of humanized APOE mouse models reveals source and genotype dependent differencesNa Wang, Gefei Yu, Zhen Wang, Alla Alnobani, Suren Jeevaratnam, Xue Zhang, Meghan G. McReynolds, Yuzhou Chang, Fangfang Qi, William Tauer et al. · 2026 · Molecular Neurodegeneration
- Aortic Single-Cell Transcriptome Analysis Reveals ApoE-Isoform-Specific Influences on Vascular DiseaseDavid Y. Hui, Jeyashree Alagarsamy, April M. Haller, Mario Medvedovic, Anja Jaeschke · 2026 · International Journal of Molecular Sciences
- The effect of chicken extract on ERK/CREB signaling is ApoE isoform-dependentShan May Yong, Qi-Rui Ong, Bei En Siew, Boon‐Seng Wong · 2014 · Food & Function
- APOE-Based Models of “Pre-Dementia”Patrick M. Sullivan · 2010 · Neuromethods
- Increase of serum uric acid levels associated with APOE ε2 haplotype: a clinico-genetic investigation and in vivo approachMasatsune Ogura, Yu Toyoda, Masayuki Sakiyama, Yusuke Kawamura, Akiyoshi Nakayama, Yoshihide Yamanashi, Tappei Takada, Seiko Shimizu, Toshihide Higashino, Mayuko Nakajima et al. · 2021 · Human Cell
- Cerebrospinal fluid lipoprotein delivery to human neuronal cells is increased in Alzheimer's disease and is dependent on apoE monomer concentrationCasey N. Bassett, Larry L. Swift, Kathleen S. Montine, William R. Markesbery, Thomas Jude Montine · 2002 · Journal of Alzheimer s Disease
- Animal and cellular models for hypolipidemic drugsAndrea Cignarella · 2008 · Expert Opinion on Drug Discovery
- Studying the Genetics of Complex But Common Human Diseases Using MiceNobuyo Maeda, Oliver Smithies · 2000 · Springer eBooks
- Development and Use of Mouse Models of AtherosclerosisPeggy Robinet, Jonathan D. Smith · 2015 · Atherosclerosis
- EVALUATION OF HIGH-THROUGHPUT METHODOLOGY FOR MULTI-GENE SCREENING IN PATIENTS WITH NON- ALCOHOLIC FATTY LIVER DISEASE (NAFLD)Leslie R. Fisher · 2011 · SUNScholar (Stellenbosch University)
- Yeast as a Model for Studying Aβ Aggregation, Toxicity and ClearancePrashant Bharadwaj · 2011 · Australasian Journal of Paramedicine
- Absolute Winding Number Differentiates Spatial Navigation Strategies with Genetic Risk for Alzheimer's DiseaseAlexandra Badea, Didong Li, Andrei R. Niculescu · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Mechanisms underlying the atherosclerosis risk associated with apolipoprotein E isoforms in humansMichael K. Altenburg · 2007 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
- Étude de l’interaction entre stress chronique et polymorphisme de l’apolipoprotéine E dans les processus émotionnels et cognitifs chez la souris : implications dans la maladie d’Alzheimer?Alexis Koutseff · 2011 · OpenGrey (Institut de l'Information Scientifique et Technique)
- Genes That Modify Susceptibility to Atherosclerosis: Targets for Drug ActionJoshua W. Knowles · 2004 · Handbook of experimental pharmacology
- Nuclear receptors in control of cholesterol transportJelske N. van der Veen · 2007 · University of Groningen research database (University of Groningen / Centre for Information Technology)
- The impact of low density lipoprotein oxidation on platelet responsivenessJ.A. Korporaal · 2005 · Utrecht University Repository (Utrecht University)
- Lipoprotein lipase, hypertriglyceridemia and atherosclerosisJaap Rip · 2006 · UvA-DARE (University of Amsterdam)
- 445 PPARA GENE LEVEL DIFFERENTLY AFFECTS LIPID METABOLISM AND INFLAMMATION IN APOLIPOPROTEIN E2 KNOCK-IN MICEFanny Lalloyer, Kristiaan Wouters, Emmanuelle Vallez · 2011 · Atherosclerosis Supplements
- Menopause and Ovarian Reserve: Genetic and Clinical AspectsJeroen van Disseldorp · 2010 · Utrecht University Repository (Utrecht University)
- Effects of low-density lipoprotein receptor-related protein 4 and apolipoprotein E isoforms on bone metabolism in vivoAm Fachbereich Biologie, Marco Dieckmann · 2010
- MOLECULAR REGULATION OF VASCULAR CALCIFICATION IN MURINE MODELS OF ATHEROSCLEROSISShanshan Gao · 2015 · Digital Commons-TMC (Texas Medical Center)
- Les animaux génétiquement modifiésNadine Baroukh, Laurent Vergnes, Maria A. Ostos, Mario M. Zakin, Alberto Ochoa · 2000 · Annales de l Institut Pasteur / Actualités
- Peroxisome proliferator activated receptor-gamma P465L mutation in diabetes and atherosclerosisAvani A. Pendse · 2010 · ProQuest Demo Repository
- Fibrin Formation and Dissolution in the Progression of Amyloid-Beta Pathology in Alzheimer's DiseasePaul, Justin · 2025 · Digital Commons - RU (Rockefeller University)
- How Can we Know What the Latest Findings Mean?Martin Kohlmeier · 2013 · Elsevier eBooks
- Isoform-dependent effects of apoE on doublecortin-positive cells and microtubule-associated protein 2 immunoreactivity followingJacob Raber · 2010
- A study of the global effects of Apolipoprotein E using lipidomicsJade I. Hawksworth · 2019 · ORCA Online Research @Cardiff (Cardiff University)
- APOE2 promotes longevity independent of Alzheimer’s diseaseMitsuru Shinohara, Takahisa Kanekiyo, Masaya Tachibana, Aishe Kurti, Motoko Shinohara, Yuan Fu, Jing Zhao, Xianlin Han, Patrick M. Sullivan, William G. Rebeck et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- EXAMINING HUMAN APOE GENOTYPE AND SEX AS MODULATORS OF RESPIRATORY PLASTICITY IN THE PRESENCE AND ABSENCE OF SPINAL CORD INJURYLydia E. Strattan · 2021 · UKnowledge (University of Kentucky)
- Modelling of ischemic stroke : focus on co-morbidities and therapeutic interventionHiramani Dhungana · 2014 · UEF eRepo (University of Eastern Finland)
- Two-Time Scale Control of a High Speed Planar Parallel Manipulator With Structural FlexibilityBong-Soo Kang, James K. Mills · 2002
- Contents&NA; · 1999 · Current Opinion in Lipidology
- Genetic Substrates of Brain Vulnerability and Resilience in Aging APOE2 MiceAli Mahzarnia, Hae Sol Moon, Jacques Andrew Stout, Robert J. Anderson, Madison Strain, Jessica T. Tremblay, Zay Yar Han, Andrei Niculescu, Anna MacFarlane, Jasmine King et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Apolipoprotein E Isoform-Related Translational Measures in PTSD ResearchEileen Ruth S. Torres, Andrea E. DeBarber, Jacob Raber · 2023 · Neuromethods
- APOE2 Heterozygosity Reduces Hippocampal Soluble Amyloid-β42 Levels in Non-Hyperlipidemic MiceAna Carolina Valencia‐Olvera, Deebika Balu, Annabelle Moore, Maitri Shah, Rebecca Ainis, Bingtao Xiang, Yaseen Saleh, Dongming Cai, Mary Jo LaDu, Leon M. Tai · 2024 · Journal of Alzheimer s Disease
- Microbiome Experimentation 2.0Jagriti Ramanathan · 2025 · Springer eBooks
- ApoE, Atherosclerosis, and HypercholesterolemiaWeibin Shi · 2025 · Springer eBooks
- Flipping APOE to reverse Alzheimer’s disease traitsJeff Y. L. Lam, Kai Wang, Guojun Bu · 2025 · Nature Neuroscience
- Additional file 2 of APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysisBrandon C. Farmer, Holden C. Williams, Nicholas A. Devanney, Margaret A. Piron, Grant K. Nation, D.J. Carter, Adeline E. Walsh, Rebika Khanal, Lyndsay E.A. Young, Jude C. Kluemper et al. · 2021 · Figshare
- Additional file 5 of Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathyTristan Williams, Tim Bathe, Quan Vo, Patricia Sacilotto, McFarland, Karen, Alejandra Jolie Ruiz, Gabriela P. Hery, Patrick M. Sullivan, Borchelt, David R., Stefan Prokop et al. · 2023 · Figshare
- Additional file 6 of Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathyTristan Williams, Tim Bathe, Quan Vo, Patricia Sacilotto, McFarland, Karen, Alejandra Jolie Ruiz, Gabriela P. Hery, Patrick M. Sullivan, Borchelt, David R., Stefan Prokop et al. · 2023 · Figshare
- Additional file 1 of Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesisGrace M. Lloyd, Long, Brooke, Stephan S. Quintin, Zachary A. Sorrentino, Gorion, Kimberly-Marie M., Brach M. Bell, Denise Carrillo, Patrick M. Sullivan, David B. Borchelt, Benoit I. Giasson · 2024 · Figshare
- Additional file 4 of Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathyTristan Williams, Tim Bathe, Quan Vo, Patricia Sacilotto, McFarland, Karen, Alejandra Jolie Ruiz, Gabriela P. Hery, Patrick M. Sullivan, Borchelt, David R., Stefan Prokop et al. · 2023 · Figshare
- Additional file 2 of Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathyTristan Williams, Tim Bathe, Quan Vo, Patricia Sacilotto, McFarland, Karen, Alejandra Jolie Ruiz, Gabriela P. Hery, Patrick M. Sullivan, Borchelt, David R., Stefan Prokop et al. · 2023 · Figshare
- Additional file 12 of Impact of APOE genotype on prion-type propagation of tauopathyTristan Williams, Alejandra Jolie Ruiz, Angelica Maria Ruiz, Quan Vo, Wangchen Tsering, Xu, Guilian, McFarland, Karen, Benoit I. Giasson, Patrick M. Sullivan, Borchelt, David R. et al. · 2022 · Figshare
- Additional file 3 of Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathyTristan Williams, Tim Bathe, Quan Vo, Patricia Sacilotto, McFarland, Karen, Alejandra Jolie Ruiz, Gabriela P. Hery, Patrick M. Sullivan, Borchelt, David R., Stefan Prokop et al. · 2023 · Figshare
- Additional file 1 of Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathyTristan Williams, Tim Bathe, Quan Vo, Patricia Sacilotto, Karen N. McFarland, Alejandra Jolie Ruiz, Gabriela P. Hery, Patrick M. Sullivan, Borchelt, David R., Stefan Prokop et al. · 2023 · Figshare
- Mouse models elucidating the role of apolipoprotein E in neurological conditionsEileen Ruth Samson Torres, Jacob Raber · 2025 · Elsevier eBooks
- Les peptides mimétiques de la Thiorédoxine-1 : nouvelle stratégie thérapeutique pour les maladies cardiovasculairesFanny Canesi · 2018 · theses.fr (ABES)
- Retinal manifestations of Alzheimer's Disease: Insights from animal models, clinical detection, and future translationXiayin Zhang, Dongli Zhuang, Chunran Lai, Chunwen Zheng, Zhi Da Soh, Siegfried K. Wagner, Vera Yuan Cai, Zhongwei Yang, Shan Wang, Xingchen Geng et al. · 2026 · Progress in Retinal and Eye Research
- Non-alcoholic steatohepatitis : second hit or strike out?Kristiaan Wouters · 2008 · Research Publications (Maastricht University)
- Die Alzheimer-Krankheit: Molekulare Grundlagen und TherapieansätzeUlrich Finckh, Christoph Höck, Roger M. Nitsch · 2004 · Springer eBooks
- Utilizing a cell culture based novel cellular thermal shift assay to understand the isoform-dependent thermal stability of ApoE variantsJackson, Rosemary J., Dierksmeier, Steven, Nishtar, Maryam, Meltzer, Jonah, Balduin, Frieda, Beaumont, Bobby, Fan, Zhanyun, Sergienko, Eduard, Olson, Steve, Jackson, Michael R. et al. · 2026