Cited by 236Growth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormonesPituitary Gland Disorders and Treatments

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Regulatory mechanisms of growth hormone secretion are sexually dimorphic.

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Jaffe, C A, Ocampo-Lim, B, Guo, W, Krueger, K, Sugahara, I, DeMott-Friberg, R, Bermann, M, Barkan, A L·1998·Journal of Clinical Investigation

DOI 10.1172/jci2908PMC PMC509077

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Abstract

Sexually dimorphic growth hormone (GH) secretory pattern is important in the determination of gender-specific patterns of growth and metabolism in rats. Whether GH secretion in humans is also sexually dimorphic and the neuroendocrine mechanisms governing this potential difference are not fully established. We have compared pulsatile GH secretion profiles in young men and women in the baseline state and during a continuous intravenous infusion of recombinant human insulin-like growth factor I (rhIGF-I). During the baseline study, men had large nocturnal GH pulses and relatively small pulses during the rest of the day. In contrast, women had more continuous GH secretion and more frequent GH pulses that were of more uniform size. The infusion of rhIGF-I (10 microg/kg/h) potently suppressed both spontaneous and growth hormone-releasing hormone (GHRH)-induced GH secretion in men. In women, however, rhIGF-I had less effect on pulsatile GH secretion and did not suppress the GH response to GHRH. These data demonstrate the existence of sexual dimorphism in the regulatory mechanisms involved in GH secretion in humans. The persistence of GH responses to GHRH in women suggests that negative feedback by IGF-I might be expressed, in part, through suppression of hypothalamic GHRH.

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Authors: Jaffe, C. A., Ocampo-Lim, B., Guo, W., Krueger, K., Sugahara, I., DeMott-Friberg, R., Bermann, M., & Barkan, A. L.
Affiliations: University of Michigan (US)
ORCID: Barkan, A L
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1998-07-01
Volume: 102
Issue: 1
Pages: 153-164
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci2908
PMC: PMC509077
OpenAlex: W2073152302
Cited by: 236
References: 47
Citations by year: 2026: 5 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 13 · 2016: 7 · 2015: 6 · 2014: 9 · 2013: 10 · 2012: 3
FWCI: 7.38
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
National Institutes of Health (5r01dk038449-09, RR0043, 5u54hd029184-03, P60DK20572)
Genentech
National Institute of Diabetes and Digestive and Kidney Diseases (R0-1 DK-38449)
National Center for Research Resources (MO1-RR0042-34S3, M01RR000042)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54 HD-29184)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords: growth hormone secretion, sexual dimorphism, pulsatile secretion, insulin-like growth factor I, recombinant human IGF-I, growth hormone-releasing hormone, negative feedback, hypothalamus, sex differences
MeSH terms: Adult, Estradiol, Female, Humans, Insulin-Like Growth Factor I, Male, Recombinant Proteins, Sex Factors, Growth Hormone-Releasing Hormone, Testosterone, Thyrotropin, Insulin-Like Growth Factor Binding Proteins, Human Growth Hormone

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Regulatory mechanisms of growth hormone secretion are sexually dimorphic.

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