The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
Open accessAbstract
Systemic iron balance is regulated by hepcidin, a peptide hormone secreted by the liver.By decreasing cell surface expression of the iron exporter ferroportin, hepcidin decreases iron absorption from the intestine and iron release from reticuloendothelial stores.Hepcidin excess has been implicated in the pathogenesis of anemia of chronic disease, while hepcidin deficiency has a key role in the pathogenesis of the iron overload disorder hemochromatosis.We have recently shown that hemojuvelin is a coreceptor for bone morphogenetic protein (BMP) signaling and that BMP signaling positively regulates hepcidin expression in liver cells in vitro.Here we show that BMP-2 administration increases hepcidin expression and decreases serum iron levels in vivo.We also show that soluble hemojuvelin (HJV.Fc) selectively inhibits BMP induction of hepcidin expression in vitro and that administration of HJV.Fc decreases hepcidin expression, increases ferroportin expression, mobilizes splenic iron stores, and increases serum iron levels in vivo.These data support a role for modulators of the BMP signaling pathway in treating diseases of iron overload and anemia of chronic disease.Nonstandard abbreviations used: BMP, bone morphogenetic protein; GDF, growth and differentiation factor; HJV.Fc, soluble hemojuvelin comprised of the extracellular domain of hemojuvelin fused to the Fc portion of human IgG; pRL-TK, Renilla luciferase vector.
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Cites
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
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Hepcidin, a urinary antimicrobial peptide synthesized in the liver
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LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
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Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
Babitt, J. L., Huang, F. W., Wrighting, D. M., Xia, Y., Sidis, Y., Samad, T. A., Campagna, J. A., Chung, R. T., Schneyer, A. L., Woolf, C. J., et al. (2006) · Nature Genetics · doi:10.1038/ng1777 · Cited by 1,026
Interleukin-6 induces hepcidin expression through STAT3
Wrighting, D. M., & Andrews, N. C. (2006) · Blood · doi:10.1182/blood-2006-06-027631 · Cited by 983
Self-citationMutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis
Papanikolaou, G., Samuels, M. E., Ludwig, E. H., MacDonald, M. L. E., Franchini, P. L., Dubé, M.-P., Andres, L., MacFarlane, J., Sakellaropoulos, N., Politou, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1274 · Cited by 974
Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
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STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
Verga Falzacappa, M. V., Vujic Spasic, M., Kessler, R., Stolte, J., Hentze, M. W., & Muckenthaler, M. U. (2007) · Blood · doi:10.1182/blood-2006-07-033969 · Cited by 567
STAT3 Is Required for IL-6-gp130–Dependent Activation of Hepcidin In Vivo
Pietrangelo, A., Dierssen, U., Valli, L., Garuti, C., Rump, A., Corradini, E., Ernst, M., Klein, C., & Trautwein, C. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.10.018 · Cited by 315
Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis
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Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin
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Cited by
Weiss, G., & Goodnough, L. T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041809 · Cited by 3,800
Ganz, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00008.2013 · Cited by 1,122
Hepcidin and iron regulation, 10 years later
Ganz, T. (2011) · Blood · doi:10.1182/blood-2011-01-258467 · Cited by 962
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
Andriopoulos Jr, B., Corradini, E., Xia, Y., Faasse, S. A., Chen, S., Grgurevic, L., Knutson, M. D., Pietrangelo, A., Vukicevic, S., Lin, H. Y., et al. (2009) · Nature Genetics · doi:10.1038/ng.335 · Cited by 769
Self-citationHereditary Hemochromatosis: Pathogenesis, Diagnosis, and Treatment
Pietrangelo, A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.06.013 · Cited by 615
Metadata
- Authors
- Babitt, J. L., Huang, F. W., Xia, Y., Sidis, Y., Andrews, N. C., & Lin, H. Y.
- Venue
- Journal of Clinical Investigation
- Published
- 2007-07-02
- Volume
- 117
- Issue
- 7
- Pages
- 1933-1939
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2117133328
- Cited by
- 457
- References
- 16
- FWCI
- 28.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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