The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
IL-13Rα2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice
Open accessAbstract
Development of persistent Th2 responses in asthma and chronic helminth infections are a major health concern. IL-10 has been identified as a critical regulator of Th2 immunity, but mechanisms for controlling Th2 effector function remain unclear. IL-10 also has paradoxical effects on Th2-associated pathology, with IL-10 deficiency resulting in increased Th2-driven inflammation but also reduced airway hyperreactivity (AHR), mucus hypersecretion, and fibrosis. We demonstrate that increased IL-13 receptor alpha 2 (IL-13Ralpha2) expression is responsible for the reduced AHR, mucus production, and fibrosis in BALB/c IL-10(-/-) mice. Using models of allergic asthma and chronic helminth infection, we demonstrate that IL-10 and IL-13Ralpha2 coordinately suppress Th2-mediated inflammation and pathology, respectively. Although IL-10 was identified as the dominant antiinflammatory mediator, studies with double IL-10/IL-13Ralpha2-deficient mice illustrate an indispensable role for IL-13Ralpha2 in the suppression of AHR, mucus production, and fibrosis. Thus, IL-10 and IL-13Ralpha2 are both required to control chronic Th2-driven pathological responses.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Macrophages, however, can also regulate or reverse fibrosis through the secretion of matrix degrading MMPs and other M2 factors that have been shown to suppress fibrosis (IL-10, RELMα, Arg-1) [102,138–140].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [140]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
Interleukin-13: Central Mediator of Allergic Asthma
Wills-Karp, M. A., Luyimbazi, J., Xu, X., Schofield, B., Neben, T. Y., Karp, C. L., & Donaldson, D. D. (1998) · Science · doi:10.1126/science.282.5397.2258 · Cited by 2,611
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Grünig, G., Warnock, M. L., Wakil, A. E., Venkayya, R., Brombacher, F., Rennick, D. M., Sheppard, D., Mohrs, M., Donaldson, D. D., Locksley, R. M., et al. (1998) · Science · doi:10.1126/science.282.5397.2261 · Cited by 1,845
Zhu, Z., Homer, R., Wang, Z., Chen, Q., Geba, G. P., Wang, J., Zhang, Y., & Elias, J. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5909 · Cited by 1,730
Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography
Hamelmann, E. H., Schwarze, J., Takeda, K., Oshiba, A., Larsen, G. L., Irvin, C. G., & Gelfand, E. W. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.3.9606031 · Cited by 1,286
Heller, F., Florian, P., Bojarski, C., Richter, J. F., Christ, M., Hillenbrand, B., Mankertz, J., Gitter, A. H., Bürgel, N., Fromm, M., et al. (2005) · Gastroenterology · doi:10.1016/j.gastro.2005.05.002 · Cited by 1,232
IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY HYPERRESPONSIVENESS
Wills-Karp, M. A. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.255 · Cited by 1,022
Wynn, T. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141142 · Cited by 991
Self-citationRegulation Of Immunity To Parasites By T Cells And T Cell-Derived Cytokines
Sher, A., & Coffman, R. L. (1992) · Annual Review of Immunology · doi:10.1146/annurev.iy.10.040192.002125 · Cited by 846
Chiaramonte, M. G., Donaldson, D. D., Cheever, A. W., & Wynn, T. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7325 · Cited by 603
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–137 of 137
Dhital, S., Rice, C. D., & Vyavahare, N. R. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174487 · Cited by 17
Kannan, Y., Li, Y., Coomes, S. M., Okoye, I., Pelly, V. S., Sriskantharajah, S., Gückel, E., Webb, L. M., Czieso, S., Nikolov, N., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.05.031 · Cited by 14
Self-citationPlatycodi Radix suppresses development of atopic dermatitis-like skin lesions
Choi, J. H., Han, E. H., Park, B. H., Kim, H. G., Hwang, Y. P., Chung, Y. C., Lee, Y. C., & Jeong, H. G. (2012) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2012.02.002 · Cited by 12
Inhibition of interleukin‐13 gene expression by triptolide in activated T lymphocytes
Dai, S., Yin, K., Yao, X., & Zhou, L. (2013) · Respirology · doi:10.1111/resp.12145 · Cited by 11
Wowk, P. F., Franco, L. H., da Fonseca, D. M., Paula, M. O. E., Vianna, É. O., Wendling, A. P. B., Augusto, V. M., Elói-Santos, S. M., Teixeira‐Carvalho, A., da Silva, F. D. C., et al. (2017) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2016.1264547 · Cited by 10
Effect of sIL-13Rα2-Fc on the progression of rat tail intervertebral disc degeneration
Wang, X., Sun, J., Tan, J., Fang, P., Chen, J., Yuan, W., Chen, H., & Liu, Y. (2019) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-019-1361-0 · Cited by 10
Modulation of human T cell cytokines by the Mycobacterium tuberculosis -secreted protein Wag31
Samten, B., Fannin, S., Sarva, K., Yi, N., Madiraju, M. V. V. S., & Rajagopalan, M. R. (2016) · Tuberculosis · doi:10.1016/j.tube.2016.09.017 · Cited by 10
IL-13, Asthma and Glycosylation in Airway Epithelial Repair
Samuel, J., Jasemine, S., & Delbert, R. (2012) · InTech eBooks · doi:10.5772/51970 · Cited by 9
Natural Tr1-like cells do not confer long-term tolerogenic memory
Yadava, K., Medina, C. O., Ishak, H. D., Gurevich, I., Kuipers, H. F., Shamskhou, E. A., Koliesnik, I. O., Moon, J. J., Weaver, C. T., Nadeau, K. C., et al. (2019) · eLife · doi:10.7554/elife.44821 · Cited by 9
Madala, S. K., Dolan, M. A., Sharma, D., Ramalingam, T. R., Wilson, M. S., Mentink‐Kane, M. M., Masison, D. C., & Wynn, T. A. (2010) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.22881 · Cited by 8
Self-citationMaggi, L., Camelo, G. M. A., Rocha, I. C., Alves, W. P., Moreira, J. M. P., Pereira, T. A., Tafuri, W. L., Rabelo, É. M. L., Corrêa, A., Ecco, R., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210237 · Cited by 7
Figueiredo, A. L. C., Domingues, A. L. C., Melo, W. G., Tashiro, T., de Lorena, V. M. B., Montenegro, S. M. L., & de Morais, C. N. L. (2016) · Scandinavian Journal of Immunology · doi:10.1111/sji.12472 · Cited by 6
Sahputra, R., Murphy, E. A., Forman, R. A., Mair, I., Fadlullah, M. Z. H., Waisman, A., Müller, W., & Else, K. J. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01954-3 · Cited by 5
Wang, X., Tan, J., Sun, J., Fang, P., Chen, J., Yuan, W., Chen, H., & Liu, Y. (2020) · BioMed Research International · doi:10.1155/2020/7645989 · Cited by 5
Shibui, A., Nambu, A., Shimura, E., Yamaguchi, S., Shiraishi, C., Sato, Y., Okumura, K., Sugano, S., Hozumi, N., & Nakae, S. (2011) · Allergology International · doi:10.2332/allergolint.10-oa-0283 · Cited by 4
Kwon, S., Chung, E. J., Santwana, K. C., White, A. O., Chung, S. I., Horton, J. A., Yun, H. S., Ahn, J. H., Shankavaram, U. T., Chung, J., et al. (2024) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2024.11.103 · Cited by 3
Effect of Xinjiang UyghurVernonia anthelminticaWilld Injection Treatment with Silicosis Fibrosis
Liu, G., Liu, Y., Lu, J., Li, C., Nie, L., Wei, Y., Wang, W., Xu, Y., Nusilaiti, N., Hua, P., et al. (2016) · BioMed Research International · doi:10.1155/2016/5139651 · Cited by 3
(2007) · Nature reviews. Immunology · doi:10.1038/nri2210 · Cited by 2
Yang, L., Dai, Q., Bao, X., Li, W., & Liu, J. (2023) · Cytotechnology · doi:10.1007/s10616-023-00607-w · Cited by 2
PD-L1 promotes early-life chlamydia respiratory infection-induced severe allergic airway disease
Starkey, M. R., Nguyen, D. H., Brown, A. C., Essilfie, A., Kim, R., Yagita∥, H., Horvat, J. C., & Hansbro, P. M. (2016) · NOVA (University of Newcastle Australia) · Cited by 2
A potential three-gene-based diagnostic signature for idiopathic pulmonary fibrosis
Wu, Y. C., Zhong, L., Li, Q., Dong, L., Yang, L., & Chen, L. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2022.985217 · Cited by 2
T Regulatory Mechanisms in Airway and Interstitial Lung Disease
Pastore, C., Stadler, B. D., Sperling, A. I., & Velez, T. E. (2025) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/a-2703-4491 · Cited by 2
The Switch: Mechanisms Governing Macrophage Phenotypic Variability in Liver Disease
Marentette, J., & Ju, C. (2017) · Springer eBooks · doi:10.1007/978-3-319-58106-4_4 · Cited by 1
Dill, M. N., Turner, Z. R., Kapuscinska, P. W., Heiden, K. D., Basso, K. B. G., Simmons, C. S., & Moore, E. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c00810 · Cited by 1
Regulatory T-Cell Control of Type 2 Inflammation
Maizels, R. M. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2911-5_5 · Cited by 1
Figueiredo, A. L. D. C. (2014) · Americanae (AECID Library)
Ferraro, P., Grütter, P., Martin, J. G., Risse, P., Jo, T., Suárez‐Obando, F., & Hirota, N. (2011)
Wilson, M. S. (2012) · doi:10.1002/9781118393321.ch16
Self-citationPolarized Macrophages in Hypertrophic Scar Formation
Zhu, Z. (2016) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3fx74c9s
(2008) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328317a234
WARDLE, E. N. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-538-5_13
Allergy as a potential aetiology of micturition disorders in children
Rakowska, M., Lipińska‐Opałka, A., Jobs, K., Zieniuk, K., Rustecka, A., & Kalicki, B. (2023) · Pediatria i Medycyna Rodzinna · doi:10.15557/pimr.2023.0055
Hayashi, Y., Suga, K., Suto, A., Iwata, A., Ishikawa, J., Abe, K., Kageyama, T., Ito, T., Tanaka, S., Suzuki, K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.04.686669
Kuang, P.-P., Liu, X.-Q., Li, C.-G., He, B.-X., Xie, Y.-C., Wu, Z.-C., Li, C.-L., Deng, X.-H., & Fu, Q.-L. (2023) · Figshare · doi:10.6084/m9.figshare.24804314
Dentofacial Malocclusion and Salivary Biomarkers in Asthmatic Patients: A Scoping Review
Raghavan, S., Alhaija, E. S. A., & Almashraqi, A. A. (2026) · International Dental Journal · doi:10.1016/j.identj.2026.109422
IL-13Rα2 in liver cancer: Endothelial target for precision therapy
Liu, Q., 李娅妮, Tao, R., Yuan, Y., Chen, M., Liang, J., Song, J. L., Zhao, J., Yuan, G., Xu, D., et al. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119321
IL-13Rα2 Regulates C2C12 Myoblast Proliferation via the Akt–Cyclin D1–CDK4 Pathway
Kurosaka, M., & Kohda, K. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27125600
Metadata
- Authors
- Wilson, M. S., Elnekave, E., Mentink-Kane, M. M., Hodges, M. G., Pesce, J. T., Ramalingam, T. R., Thompson, R. W., Kamanaka, M., Flavell, R. A., Keane-Myers, A., Cheever, A. W., & Wynn, T. A.
- Affiliations
- National Institutes of Health (US)
- Yale University (US)
- Biomedical Research Institute (US)
- Corresponding author
- Wynn, Thomas A.
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2007-10-01
- Volume
- 117
- Issue
- 10
- Pages
- 2941-2951
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1978425
- OpenAlex
- W2135565397
- Cited by
- 137
- References
- 63
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 2 · 2023: 8 · 2022: 2 · 2021: 5 · 2020: 8 · 2019: 9 · 2018: 6 · 2017: 6 · 2016: 12 · 2015: 11 · 2014: 5 · 2013: 6 · 2012: 12
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- IL-13 receptor alpha 2, IL-10, airway hyperresponsiveness, airway fibrosis, mucus hypersecretion, Th2 immune response, allergic asthma, chronic helminth infection, airway inflammation, IL-10-deficient mice, double knockout mice
- MeSH terms
- Animals, Asthma, Bronchitis, Fibrosis, Granuloma, Mice, Mutant Strains, Mucus, Bronchial Hyperreactivity, Interleukin-10, Th1 Cells, Th2 Cells, Mice, Interleukin-13 Receptor alpha2 Subunit
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
