Wynn, Thomas A.

Macrophage activation and polarization: nomenclature and experimental guidelines

Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity

Immune cells in cancerImmune responses and vaccinations

Cited by 6,337

Protective and pathogenic functions of macrophage subsets

Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology

Immune cells in cancerPhagocytosis and Immune Regulation

Cited by 5,269

Macrophage biology in development, homeostasis and disease

Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature

Immune cells in cancerPhagocytosis and Immune Regulation

Cited by 4,684

Macrophages in Tissue Repair, Regeneration, and Fibrosis

Wynn, T. A., & Vannella, K. M. (2016) · Immunity

Wound Healing and TreatmentsImmune cells in cancer

Cited by 4,481

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisLiver physiology and pathology

Cited by 3,541

Fibrosis: from mechanisms to medicines

Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature

Liver physiology and pathologyInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 1,868

Fibrotic disease and the TH1/TH2 paradigm

Wynn, T. A. (2004) · Nature Reviews Immunology

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisSystemic Sclerosis and Related Diseases

Cited by 1,765

Macrophages: master regulators of inflammation and fibrosis

Wynn, T., & Barron, L. (2010) · Seminars in Liver Disease

Liver physiology and pathologyCardiac Fibrosis and Remodeling

Cited by 1,392

Inflammation and metabolism in tissue repair and regeneration

Eming, S. A., Wynn, T. A., & Martin, P. (2017) · Science

Wound Healing and TreatmentsInflammation biomarkers and pathways

Cited by 1,369

Type 2 immunity in tissue repair and fibrosis

Gieseck, R. L., Wilson, M. S., & Wynn, T. A. (2018) · Nature Reviews Immunology

IL-33, ST2, and ILC PathwaysWound Healing and Treatments

Cited by 1,055

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

Galli, S. J., Borregaard, N., & Wynn, T. A. (2011) · Nature Immunology

Immune cells in cancerImmune responses and vaccinations

Cited by 1,055

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

Pesce, J. T., Ramalingam, T. R., Mentink-Kane, M. M., Wilson, M. S., El Kasmi, K. C., Smith, A. M., Thompson, R. W., Cheever, A. W., Murray, P. J., & Wynn, T. A. (2009) · PLoS Pathogens

Parasites and Host InteractionsImmune cells in cancer

Cited by 816

Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent

Wilson, M. S., Madala, S. K., Ramalingam, T. R., Gochuico, B. R., Rosas, I. O., Cheever, A. W., & Wynn, T. A. (2010) · Journal of Experimental Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisTransplantation: Methods and Outcomes

Cited by 730

Mechanisms of Organ Injury and Repair by Macrophages

Vannella, K. M., & Wynn, T. A. (2017) · Annual Review of Physiology

Wound Healing and TreatmentsLiver physiology and pathology

Cited by 656

Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

El Kasmi, K. C., Qualls, J. E., Pesce, J. T., Smith, A. M., Thompson, R. W., Henao-Tamayo, M., Basaraba, R. J., König, T., Schleicher, U., Koo, M.-S., et al. (2008) · Nature Immunology

Immune Response and InflammationTuberculosis Research and Epidemiology

Cited by 646

An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2–dominated inflammatory response

Chiaramonte, M. G., Donaldson, D. D., Cheever, A. W., & Wynn, T. A. (1999) · Journal of Clinical Investigation

Parasites and Host InteractionsLiver physiology and pathology

Cited by 603

T H 2 and T H 17 inflammatory pathways are reciprocally regulated in asthma

Choy, D. F., Hart, K. M., Borthwick, L. A., Shikotra, A., Nagarkar, D. R., Siddiqui, S., Jia, G., Ohri, C. M., Doran, E., Vannella, K. M., et al. (2015) · Science Translational Medicine

Asthma and respiratory diseasesIL-33, ST2, and ILC Pathways

Cited by 450

Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity

Spencer, S. P., Wilhelm, C., Yang, Q., Hall, J. A., Bouladoux, N., Boyd, A., Nutman, T. B., Urban, J. F., Wang, J., Ramalingam, T. R., et al. (2014) · Science

IL-33, ST2, and ILC PathwaysT-cell and B-cell Immunology

Cited by 447

Impaired Host Defense, Hematopoiesis, Granulomatous Inflammation and Type 1–Type 2 Cytokine Balance in Mice Lacking CC Chemokine Receptor 1

Gao, J.-L., Wynn, T. A., Chang, Y., Lee, E. J., Broxmeyer, H. E., Cooper, S., Tiffany, H. L., Westphal, H., Kwon-Chung, J., & Murphy, P. M. (1997) · The Journal of Experimental Medicine

Chemokine receptors and signalingInflammation biomarkers and pathways

Cited by 441

Cytokine mediated tissue fibrosis

Borthwick, L. A., Wynn, T. A., & Fisher, A. J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Wound Healing and TreatmentsLiver physiology and pathology

Cited by 375

IL-13 Activates a Mechanism of Tissue Fibrosis That Is Completely TGF-β Independent

Kaviratne, M., Hesse, M., Leusink, M., Cheever, A. W., Davies, S. J., McKerrow, J. H., Wakefield, L. M., Letterio, J. J., & Wynn, T. A. (2004) · The Journal of Immunology

Liver physiology and pathologyTGF-β signaling in diseases

Cited by 370

Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation

Fabre, T., Barron, A. M. S., Christensen, S. M., Asano, S., Bound, K., Lech, M. P., Wadsworth, M. H., Chen, X., Wang, C., Wang, J., et al. (2023) · Science Immunology

Liver physiology and pathologyCardiac Fibrosis and Remodeling

Cited by 355

Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation.

Oswald, I. P., Wynn, T. A., Sher, A., & James, S. L. (1992) · Proceedings of the National Academy of Sciences

Parasites and Host InteractionsCytokine Signaling Pathways and Interactions

Cited by 353

Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages

Barron, L., & Wynn, T. A. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Wound Healing and TreatmentsLiver physiology and pathology

Cited by 304